SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g3a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		5 / 12 ILE A 129
LEU A 192
LEU A 176
ALA A 175
LEU A 149
 None
 1.19A 1g5yB-4g3aA:
undetectable		 1g5yB-4g3aA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		4 / 5 ILE A 170
PRO A 171
PHE A 137
ILE A 152
 None
 0.94A 2hjhA-4g3aA:
undetectable		 2hjhA-4g3aA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		4 / 8 LEU A 113
LEU A  99
LEU A  92
ARG A  98
 None
 1.03A 2xn3A-4g3aA:
undetectable
2xn3B-4g3aA:
undetectable		 2xn3A-4g3aA:
21.84
2xn3B-4g3aA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		4 / 5 ILE A  96
HIS A 139
ARG A  98
GLY A 100
 None
 1.26A 3b9mA-4g3aA:
undetectable		 3b9mA-4g3aA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		5 / 12 LEU A  76
LEU A 113
ILE A  51
GLY A  53
LEU A  58
 None
 1.08A 3n8xB-4g3aA:
undetectable		 3n8xB-4g3aA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		4 / 4 LEU A  50
GLY A  48
MET A  55
PHE A  84
 None
 1.44A 3vaqB-4g3aA:
undetectable		 3vaqB-4g3aA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		4 / 7 ASN A 154
ARG A 115
GLN A 111
GLU A 147
 None
 1.32A 4mv7A-4g3aA:
undetectable		 4mv7A-4g3aA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		5 / 10 LEU A  31
LEU A  35
ALA A  72
LEU A  80
LEU A  54
 None
 1.15A 4p65A-4g3aA:
undetectable
4p65B-4g3aA:
undetectable
4p65F-4g3aA:
undetectable
4p65H-4g3aA:
undetectable		 4p65A-4g3aA:
7.98
4p65B-4g3aA:
9.27
4p65F-4g3aA:
9.27
4p65H-4g3aA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		5 / 11 LEU A  31
LEU A  35
ALA A  72
LEU A  54
LEU A  80
 None
 1.10A 4p65C-4g3aA:
undetectable
4p65D-4g3aA:
undetectable
4p65J-4g3aA:
undetectable
4p65L-4g3aA:
undetectable		 4p65C-4g3aA:
7.98
4p65D-4g3aA:
9.27
4p65J-4g3aA:
9.27
4p65L-4g3aA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		5 / 12 LEU A  54
ILE A  13
LEU A  31
LEU A  35
ALA A  72
 None
 1.06A 4p65F-4g3aA:
undetectable
4p65H-4g3aA:
undetectable
4p65K-4g3aA:
undetectable
4p65L-4g3aA:
undetectable		 4p65F-4g3aA:
9.27
4p65H-4g3aA:
9.27
4p65K-4g3aA:
7.98
4p65L-4g3aA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		4 / 7 LEU A 192
TYR A 196
LEU A 221
GLU A 222
 None
 0.98A 4z4fA-4g3aA:
undetectable		 4z4fA-4g3aA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		4 / 7 LEU A 192
TYR A 196
LEU A 221
GLU A 222
 None
 0.93A 5t7bA-4g3aA:
undetectable		 5t7bA-4g3aA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		5 / 9 ILE A  96
ASP A 101
GLY A 100
ASN A 141
ALA A  66
 None
 1.21A 5x66C-4g3aA:
undetectable		 5x66C-4g3aA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 4g3a CLIP-ASSOCIATING
PROTEIN
(Drosophila
melanogaster) 		5 / 10 ILE A  96
ASP A 101
GLY A 100
ASN A 141
ALA A  66
 None
 1.22A 5x66D-4g3aA:
undetectable		 5x66D-4g3aA:
22.59