SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g3h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		4 / 7 PHE A 270
VAL A 180
VAL A 226
ILE A 229
 None
 0.97A 1p7rA-4g3hA:
undetectable		 1p7rA-4g3hA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		3 / 3 ARG A 196
VAL A 184
THR A 187
 None
 0.73A 2nmzA-4g3hA:
undetectable		 2nmzA-4g3hA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAM_B_LLLB500_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		5 / 11 SER A  88
ASN A  93
ASP A  18
ASP A 234
ASP A 236
 None
None
None
MN  A 501 ( 2.8A)
MN  A 501 (-2.3A)
 1.33A 3hamB-4g3hA:
0.0		 3hamB-4g3hA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		4 / 4 ARG A 196
ASP A 206
GLY A 183
THR A 187
 None
 1.37A 3k4vB-4g3hA:
undetectable		 3k4vB-4g3hA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		3 / 3 ARG A 196
VAL A 184
THR A 187
 None
 0.80A 3ndtA-4g3hA:
undetectable		 3ndtA-4g3hA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		4 / 4 LEU A 165
GLY A 166
LEU A 167
GLU A 168
 None
 1.02A 3tgvB-4g3hA:
undetectable		 3tgvB-4g3hA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		5 / 12 ILE A 305
THR A  41
ILE A  42
LEU A  28
ILE A 306
 None
 1.05A 4kjkA-4g3hA:
undetectable		 4kjkA-4g3hA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		5 / 12 TYR A  50
GLY A  96
MET A  94
TYR A 230
ARG A  46
 None
 1.47A 4kovA-4g3hA:
undetectable		 4kovA-4g3hA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		4 / 7 TYR A 282
ASN A 291
GLU A 294
GLU A 295
 None
 1.21A 4mi4A-4g3hA:
undetectable
4mi4C-4g3hA:
undetectable		 4mi4A-4g3hA:
20.00
4mi4C-4g3hA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		5 / 12 ILE A 305
THR A  41
ILE A  42
LEU A  28
ILE A 306
 None
 1.04A 4pthA-4g3hA:
undetectable		 4pthA-4g3hA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		4 / 6 LEU A 231
LEU A 265
THR A 219
VAL A 180
 None
 1.01A 4udaA-4g3hA:
undetectable		 4udaA-4g3hA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		5 / 12 LEU A   6
GLY A   5
SER A 232
TYR A  50
LEU A  70
 None
 1.27A 5czyA-4g3hA:
undetectable		 5czyA-4g3hA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		3 / 3 HIS A 118
ASP A 120
HIS A 133
 MN  A 501 (-3.4A)
MN  A 500 (-2.6A)
None
 0.94A 5n1tW-4g3hA:
undetectable		 5n1tW-4g3hA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		5 / 12 GLY A  20
LYS A  19
GLN A 297
LEU A 299
LEU A 302
 None
 1.07A 5nwwA-4g3hA:
undetectable		 5nwwA-4g3hA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		5 / 12 LEU A 274
GLY A 111
LEU A 137
MET A  94
LEU A 167
 None
 1.21A 5y2tA-4g3hA:
undetectable		 5y2tA-4g3hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		5 / 12 PHE A 182
LEU A 137
ILE A 195
LEU A 266
LEU A 223
 None
 1.41A 5ycpA-4g3hA:
undetectable		 5ycpA-4g3hA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 4g3h ARGINASE (ROCF)
(Helicobacter
pylori) 		4 / 6 ILE A  71
LEU A 167
ARG A 102
SER A 103
 None
 1.28A 6f6jA-4g3hA:
undetectable		 6f6jA-4g3hA:
undetectable