SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g3m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		5 / 11 LEU A  71
ALA A 130
GLU A 131
ARG A 142
ILE A 111
 None
 1.07A 1g50A-4g3mA:
undetectable		 1g50A-4g3mA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		5 / 10 LEU A  71
ALA A 130
GLU A 131
ARG A 142
ILE A 111
 None
 1.05A 1pcgA-4g3mA:
undetectable		 1pcgA-4g3mA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		4 / 7 SER A 188
LEU A 190
GLY A 291
ILE A 326
 None
None
AI9  A 402 ( 4.0A)
None
 1.10A 2bdmA-4g3mA:
undetectable		 2bdmA-4g3mA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		5 / 12 THR A  70
ALA A 130
GLU A 131
ARG A 142
ILE A 111
 None
 1.08A 2qxsB-4g3mA:
undetectable		 2qxsB-4g3mA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		4 / 7 ILE A 218
LEU A 219
VAL A 295
GLY A 291
 None
None
None
AI9  A 402 ( 4.0A)
 0.67A 2wd9A-4g3mA:
3.1		 2wd9A-4g3mA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		4 / 8 ILE A 218
LEU A 219
VAL A 295
GLY A 291
 None
None
None
AI9  A 402 ( 4.0A)
 0.68A 2wd9B-4g3mA:
undetectable		 2wd9B-4g3mA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_2
(HIV-1 PROTEASE)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		5 / 11 ALA A  54
GLY A  27
VAL A  26
VAL A  95
ILE A  67
 None
 0.93A 3oxxD-4g3mA:
undetectable		 3oxxD-4g3mA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		5 / 12 LEU A  71
ALA A 130
GLU A 131
ARG A 142
ILE A 111
 None
 1.03A 3q95A-4g3mA:
undetectable		 3q95A-4g3mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		5 / 12 LEU A  71
ALA A 130
GLU A 131
ARG A 142
ILE A 111
 None
 1.06A 3q95B-4g3mA:
undetectable		 3q95B-4g3mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		4 / 7 ALA A 152
TYR A 311
ARG A 176
ALA A 179
 None
None
None
AI9  A 402 ( 4.7A)
 0.95A 3twpA-4g3mA:
undetectable		 3twpA-4g3mA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		4 / 7 ALA A 152
TYR A 311
ARG A 176
ALA A 179
 None
None
None
AI9  A 402 ( 4.7A)
 1.00A 3twpB-4g3mA:
undetectable		 3twpB-4g3mA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_C_SALC404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		4 / 7 ALA A 152
TYR A 311
ARG A 176
ALA A 179
 None
None
None
AI9  A 402 ( 4.7A)
 1.13A 3twpC-4g3mA:
undetectable		 3twpC-4g3mA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		3 / 3 GLY A  46
GLU A  21
THR A  20
 None
 0.57A 4kouA-4g3mA:
undetectable		 4kouA-4g3mA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		4 / 5 VAL A 295
LEU A 190
VAL A 287
PHE A 299
 None
 0.90A 4lb0B-4g3mA:
undetectable		 4lb0B-4g3mA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		5 / 10 ILE A  92
VAL A  95
ALA A  28
ALA A  54
ILE A  67
 None
 1.04A 4lbgA-4g3mA:
undetectable		 4lbgA-4g3mA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		3 / 3 TRP A 240
GLN A 235
THR A 239
 None
 0.91A 4m2xA-4g3mA:
10.9		 4m2xA-4g3mA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		4 / 6 GLY A 194
SER A 327
ILE A 160
VAL A 295
 None
 0.81A 4r21A-4g3mA:
undetectable		 4r21A-4g3mA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		5 / 12 LEU A 126
ALA A 127
ILE A  67
GLU A   2
ALA A   9
 None
 1.09A 5n5dB-4g3mA:
3.0		 5n5dB-4g3mA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		4 / 6 THR A 239
ARG A 216
ILE A 225
GLU A 227
 None
 1.00A 5uigA-4g3mA:
undetectable		 5uigA-4g3mA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		5 / 12 PRO A 214
ILE A 236
GLN A 213
ARG A 206
ILE A 189
 None
None
None
AI9  A 402 (-2.8A)
None
 1.19A 5zovB-4g3mA:
undetectable		 5zovB-4g3mA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 4g3m RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD
(Bacillus
subtilis) 		5 / 12 SER A 324
VAL A 300
GLY A 297
SER A 293
PHE A 310
 None
 1.38A 6a94A-4g3mA:
undetectable		 6a94A-4g3mA:
23.02