SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g3n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		5 / 12 THR A 627
VAL A 660
GLY A 647
ALA A 650
VAL A 651
 None
 1.13A 1jg4A-4g3nA:
undetectable		 1jg4A-4g3nA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 565
ARG A 615
ASP A 515
 None
 0.69A 1vptA-4g3nA:
undetectable		 1vptA-4g3nA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 767
SER A 675
LEU A 672
ASN A 715
 None
 1.01A 1y0xX-4g3nA:
undetectable		 1y0xX-4g3nA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 732
LEU A 803
ALA A 776
LEU A 762
VAL A 763
 None
 1.13A 2bxeA-4g3nA:
undetectable		 2bxeA-4g3nA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		5 / 9 PHE A 569
PHE A 602
ILE A 608
GLY A 524
THR A 521
 None
 1.43A 3t3rC-4g3nA:
undetectable		 3t3rC-4g3nA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		5 / 10 PHE A 569
PHE A 602
ILE A 608
GLY A 524
THR A 521
 None
 1.35A 3t3rD-4g3nA:
undetectable		 3t3rD-4g3nA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 565
ARG A 615
ASP A 515
 None
 0.78A 4fzvA-4g3nA:
undetectable		 4fzvA-4g3nA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 761
ASP A 708
ARG A 757
 None
 0.91A 4mx0A-4g3nA:
undetectable		 4mx0A-4g3nA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 740
ALA A 794
VAL A 725
GLY A 764
ALA A 765
 None
 1.07A 5kirB-4g3nA:
undetectable		 5kirB-4g3nA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 565
ARG A 615
ASP A 515
 None
 0.83A 5zvgA-4g3nA:
undetectable		 5zvgA-4g3nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 565
ARG A 615
ASP A 515
 None
 0.88A 5zvgB-4g3nA:
undetectable		 5zvgB-4g3nA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 534
VAL A 560
VAL A 518
THR A 519
 None
 1.46A 6f32B-4g3nA:
undetectable		 6f32B-4g3nA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 4g3n DNA GYRASE SUBUNIT A
(Mycobacterium
tuberculosis) 		3 / 3 VAL A 777
ALA A 814
GLN A 551
 None
 0.57A 6gb9A-4g3nA:
undetectable		 6gb9A-4g3nA:
21.25