SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A 346
VAL A 393
TRP A 391
 None
 1.00A 1av2A-4g3tA:
undetectable
1av2B-4g3tA:
undetectable		 1av2A-4g3tA:
4.85
1av2B-4g3tA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 150
VAL A 153
SER A 148
ASP A 137
ILE A 134
 None
 1.19A 1pk9C-4g3tA:
undetectable		 1pk9C-4g3tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		4 / 7 VAL A 103
VAL A  97
ALA A 111
LEU A 108
 None
 0.89A 1pthA-4g3tA:
undetectable		 1pthA-4g3tA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_E_TRPE81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 150
HIS A 152
HIS A 139
ILE A 134
GLY A 140
 None
 1.17A 1utdE-4g3tA:
undetectable
1utdF-4g3tA:
undetectable		 1utdE-4g3tA:
12.31
1utdF-4g3tA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		4 / 5 PRO A 387
GLY A 150
ASN A 151
GLY A 147
 None
 1.12A 1zlqA-4g3tA:
undetectable		 1zlqA-4g3tA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 150
VAL A 153
SER A 148
ASP A 137
ILE A 134
 None
 1.22A 3uawA-4g3tA:
undetectable		 3uawA-4g3tA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 168
THR A 169
TRP A 179
THR A 188
VAL A 451
 None
 1.23A 4e0fA-4g3tA:
undetectable		 4e0fA-4g3tA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 419
PHE A 417
ILE A 220
THR A 219
LEU A 216
 None
 0.96A 4n49A-4g3tA:
undetectable		 4n49A-4g3tA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		4 / 4 VAL A 414
ILE A 358
ASN A 392
VAL A 395
 None
 1.31A 5ajqA-4g3tA:
undetectable		 5ajqA-4g3tA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 140
GLY A 150
HIS A 152
HIS A 139
ILE A 134
 None
 1.17A 5eeyA-4g3tA:
undetectable
5eeyB-4g3tA:
undetectable		 5eeyA-4g3tA:
12.31
5eeyB-4g3tA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 140
GLY A 150
HIS A 152
HIS A 139
ILE A 134
 None
 1.17A 5ef0A-4g3tA:
undetectable
5ef0B-4g3tA:
undetectable		 5ef0A-4g3tA:
12.31
5ef0B-4g3tA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 140
GLY A 150
HIS A 152
HIS A 139
ILE A 134
 None
 1.17A 5ef2A-4g3tA:
undetectable
5ef2B-4g3tA:
undetectable		 5ef2A-4g3tA:
12.31
5ef2B-4g3tA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_A_TRPA101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 140
GLY A 150
HIS A 152
HIS A 139
ILE A 134
 None
 1.17A 5ef3A-4g3tA:
undetectable
5ef3B-4g3tA:
undetectable		 5ef3A-4g3tA:
12.31
5ef3B-4g3tA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		4 / 6 SER A 385
GLY A 150
ASN A 151
ILE A 138
 None
 1.05A 5j4nA-4g3tA:
undetectable		 5j4nA-4g3tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LYS A 266
GLN A 315
ASN A 316
 None
 1.08A 5l2tA-4g3tA:
undetectable		 5l2tA-4g3tA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		4 / 4 SER A 450
THR A 181
ASP A 137
ASP A 176
 None
 1.30A 5vimA-4g3tA:
undetectable		 5vimA-4g3tA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		4 / 4 SER A 450
THR A 181
ASP A 137
ASP A 176
 None
 1.33A 5vimB-4g3tA:
undetectable		 5vimB-4g3tA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ASP A 426
ILE A 399
PRO A 398
LEU A 340
 None
 1.42A 6mkeB-4g3tA:
undetectable		 6mkeB-4g3tA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 4g3t OXIDOREDUCTASE DPRE1
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ASP A 426
ILE A 399
PRO A 398
LEU A 340
 None
 1.44A 6mkeA-4g3tA:
undetectable		 6mkeA-4g3tA:
12.63