SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g3v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 4g3v TRANSCRIPTIONAL
REGULATOR NLH2
(Aquifex
aeolicus) 		5 / 9 LEU A  40
ILE A 132
ILE A 116
THR A 148
LEU A  36
 None
 1.08A 2m9qA-4g3vA:
undetectable		 2m9qA-4g3vA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 4g3v TRANSCRIPTIONAL
REGULATOR NLH2
(Aquifex
aeolicus) 		4 / 6 SER A 141
PHE A 136
ASP A 138
GLU A   8
 None
 1.27A 2vn1B-4g3vA:
undetectable		 2vn1B-4g3vA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 4g3v TRANSCRIPTIONAL
REGULATOR NLH2
(Aquifex
aeolicus) 		3 / 3 GLU A  43
THR A 110
HIS A 113
 CL  A 202 (-3.1A)
None
CL  A 202 (-4.0A)
 0.83A 4ydqB-4g3vA:
undetectable		 4ydqB-4g3vA:
16.16