SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4g3w TRANSCRIPTIONAL
REGULATOR NLH1
(Aquifex
aeolicus) 		4 / 6 LEU A 148
ALA A 116
LEU A 129
THR A  77
 None
 1.06A 3cfqA-4g3wA:
undetectable		 3cfqA-4g3wA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4g3w TRANSCRIPTIONAL
REGULATOR NLH1
(Aquifex
aeolicus) 		4 / 6 LEU A 148
ALA A 116
LEU A 129
THR A  77
 None
 1.07A 4i89A-4g3wA:
undetectable		 4i89A-4g3wA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4g3w TRANSCRIPTIONAL
REGULATOR NLH1
(Aquifex
aeolicus) 		4 / 6 LEU A 148
ALA A 116
LEU A 129
THR A  77
 None
 1.07A 5bojA-4g3wA:
undetectable		 5bojA-4g3wA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4g3w TRANSCRIPTIONAL
REGULATOR NLH1
(Aquifex
aeolicus) 		5 / 12 LEU A 141
ILE A 135
ASP A 139
PHE A  40
LEU A  34
 None
 1.49A 5nn8A-4g3wA:
undetectable		 5nn8A-4g3wA:
11.63