SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g41'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 LEU A  16
LEU A 222
ILE A  71
THR A  35
ILE A  44
 LEU  A  16 ( 0.6A)
LEU  A 222 ( 0.6A)
ILE  A  71 ( 0.7A)
THR  A  35 ( 0.8A)
ILE  A  44 ( 0.5A)
 1.39A 1i18A-4g41A:
undetectable
1i18B-4g41A:
undetectable		 1i18A-4g41A:
18.61
1i18B-4g41A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 THR A  35
ILE A  44
LEU A  16
LEU A 222
ILE A  71
 THR  A  35 ( 0.8A)
ILE  A  44 ( 0.5A)
LEU  A  16 ( 0.6A)
LEU  A 222 ( 0.6A)
ILE  A  71 ( 0.7A)
 1.39A 1i18A-4g41A:
undetectable
1i18B-4g41A:
undetectable		 1i18A-4g41A:
18.61
1i18B-4g41A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.69A 1jdvE-4g41A:
23.8
1jdvF-4g41A:
23.7		 1jdvE-4g41A:
24.70
1jdvF-4g41A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JDV_E_ADNE4260_1
(5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.81A 1jdvE-4g41A:
23.8
1jdvF-4g41A:
23.7		 1jdvE-4g41A:
24.70
1jdvF-4g41A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 LEU A 222
GLY A   4
LEU A  62
LEU A  43
LEU A  16
 LEU  A 222 ( 0.6A)
GLY  A   4 ( 0.0A)
LEU  A  62 ( 0.6A)
LEU  A  43 ( 0.6A)
LEU  A  16 ( 0.6A)
 1.13A 1mx1A-4g41A:
undetectable		 1mx1A-4g41A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.92A 1odiC-4g41A:
23.2		 1odiC-4g41A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_A_ADNA1245_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.64A 1pk7A-4g41A:
25.1		 1pk7A-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.90A 1pk7C-4g41A:
24.6		 1pk7C-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.80A 1pk7C-4g41A:
24.6		 1pk7C-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.74A 1pk9A-4g41A:
25.0		 1pk9A-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_A_2FAA306_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.66A 1pk9A-4g41A:
25.0		 1pk9A-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_B_2FAB307_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.72A 1pk9B-4g41A:
24.6		 1pk9B-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.91A 1pk9C-4g41A:
24.8		 1pk9C-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.72A 1pk9C-4g41A:
24.8		 1pk9C-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK9_C_2FAC308_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.74A 1pk9C-4g41A:
24.8		 1pk9C-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_A_RABA645_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.68A 1pw7A-4g41A:
25.1		 1pw7A-4g41A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.71A 1pw7B-4g41A:
24.6		 1pw7B-4g41A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.75A 1pw7C-4g41A:
24.7		 1pw7C-4g41A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_C_RABC647_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.69A 1pw7C-4g41A:
24.7		 1pw7C-4g41A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.76A 1vhwA-4g41A:
24.5
1vhwD-4g41A:
24.6		 1vhwA-4g41A:
24.82
1vhwD-4g41A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.77A 1vhwC-4g41A:
24.6
1vhwE-4g41A:
24.6		 1vhwC-4g41A:
24.82
1vhwE-4g41A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.76A 1vhwA-4g41A:
24.5
1vhwD-4g41A:
24.6		 1vhwA-4g41A:
24.82
1vhwD-4g41A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.77A 1vhwC-4g41A:
24.6
1vhwE-4g41A:
24.6		 1vhwC-4g41A:
24.82
1vhwE-4g41A:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		3 / 3 GLY A 143
ASP A  93
ASN A 167
 GLY  A 143 ( 0.0A)
ASP  A  93 ( 0.6A)
ASN  A 167 ( 0.6A)
 0.62A 1vq1A-4g41A:
undetectable		 1vq1A-4g41A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.69A 1z35A-4g41A:
23.2		 1z35A-4g41A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.80A 1z37A-4g41A:
23.1		 1z37A-4g41A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z37_A_ADNA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 9 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.81A 1z37A-4g41A:
23.1		 1z37A-4g41A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		4 / 8 LYS A  52
GLY A  51
HIS A  98
TYR A  97
 LYS  A  52 ( 0.0A)
GLY  A  51 ( 0.0A)
HIS  A  98 ( 1.0A)
TYR  A  97 ( 1.3A)
 0.82A 3af0A-4g41A:
undetectable		 3af0A-4g41A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		4 / 7 GLY A  49
GLY A  51
GLU A 174
GLU A  10
 GLY  A  49 ( 0.0A)
GLY  A  51 ( 0.0A)
GLU  A 174 ( 0.6A)
GLU  A  10 ( 0.6A)
 0.87A 3fpjB-4g41A:
undetectable		 3fpjB-4g41A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 211
GLY A  75
SER A  76
ILE A 190
ILE A  71
 ILE  A 211 ( 0.7A)
GLY  A  75 ( 0.0A)
SER  A  76 ( 0.0A)
ILE  A 190 ( 0.7A)
ILE  A  71 ( 0.7A)
 1.05A 3mb5A-4g41A:
undetectable		 3mb5A-4g41A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.90A 3uawA-4g41A:
23.9		 3uawA-4g41A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.95A 3uawA-4g41A:
23.9		 3uawA-4g41A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAW_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.80A 3uawA-4g41A:
23.9		 3uawA-4g41A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.96A 3uayA-4g41A:
24.1		 3uayA-4g41A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 LEU A 229
LEU A 226
LEU A 222
ILE A 190
ILE A   3
 LEU  A 229 ( 0.6A)
LEU  A 226 ( 0.6A)
LEU  A 222 ( 0.6A)
ILE  A 190 ( 0.7A)
ILE  A   3 ( 0.6A)
 0.81A 4a7aB-4g41A:
undetectable		 4a7aB-4g41A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 128
LEU A 222
VAL A  91
ILE A 190
VAL A 192
 ILE  A 128 ( 0.6A)
LEU  A 222 ( 0.6A)
VAL  A  91 ( 0.6A)
ILE  A 190 ( 0.7A)
VAL  A 192 ( 0.6A)
 1.05A 4c9lA-4g41A:
undetectable		 4c9lA-4g41A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 128
LEU A 222
VAL A  91
ILE A 190
VAL A 192
 ILE  A 128 ( 0.6A)
LEU  A 222 ( 0.6A)
VAL  A  91 ( 0.6A)
ILE  A 190 ( 0.7A)
VAL  A 192 ( 0.6A)
 1.06A 4c9lB-4g41A:
undetectable		 4c9lB-4g41A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 128
LEU A 222
VAL A  91
ILE A 190
VAL A 192
 ILE  A 128 ( 0.6A)
LEU  A 222 ( 0.6A)
VAL  A  91 ( 0.6A)
ILE  A 190 ( 0.7A)
VAL  A 192 ( 0.6A)
 1.04A 4c9oA-4g41A:
undetectable		 4c9oA-4g41A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A 128
LEU A 222
VAL A  91
ILE A 190
VAL A 192
 ILE  A 128 ( 0.6A)
LEU  A 222 ( 0.6A)
VAL  A  91 ( 0.6A)
ILE  A 190 ( 0.7A)
VAL  A 192 ( 0.6A)
 1.04A 4c9oB-4g41A:
undetectable		 4c9oB-4g41A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.72A 4d9hA-4g41A:
23.9		 4d9hA-4g41A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.77A 4da7A-4g41A:
23.8		 4da7A-4g41A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.78A 4danA-4g41A:
23.4		 4danA-4g41A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 GLY A  78
GLU A 172
MET A 173
GLU A 174
SER A 196
 GLY  A  78 ( 0.0A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.83A 4danA-4g41A:
23.4
4danB-4g41A:
23.4		 4danA-4g41A:
25.86
4danB-4g41A:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 12 ILE A  44
GLY A   4
ALA A 182
PHE A  66
HIS A  41
 ILE  A  44 ( 0.5A)
GLY  A   4 ( 0.0A)
ALA  A 182 ( 0.0A)
PHE  A  66 ( 1.3A)
HIS  A  41 ( 1.0A)
 0.95A 4rvdA-4g41A:
undetectable		 4rvdA-4g41A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 10 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.79A 5i3cB-4g41A:
24.9		 5i3cB-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
ILE A 158
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
ILE  A 158 ( 0.7A)
 0.79A 5i3cC-4g41A:
24.8		 5i3cC-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_C_AC2C301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		5 / 11 VAL A 171
GLU A 172
MET A 173
GLU A 174
SER A 196
 VAL  A 171 ( 0.6A)
GLU  A 172 ( 0.5A)
MET  A 173 ( 0.0A)
GLU  A 174 ( 0.6A)
SER  A 196 ( 0.0A)
 0.69A 5i3cC-4g41A:
24.8		 5i3cC-4g41A:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4g41 MTA/SAH NUCLEOSIDASE
(Streptococcus
pyogenes) 		3 / 3 VAL A 132
LEU A  84
MET A 195
 VAL  A 132 ( 0.5A)
LEU  A  84 ( 0.6A)
MET  A 195 ( 0.0A)
 0.89A 5ikrA-4g41A:
undetectable		 5ikrA-4g41A:
17.60