SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		3 / 3 THR A 210
PRO A 234
THR A 232
 None
 0.87A 1a7yB-4g4iA:
undetectable		 1a7yB-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		3 / 3 THR A 210
PRO A 234
THR A 232
 None
 0.91A 1dscC-4g4iA:
undetectable		 1dscC-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		3 / 3 THR A 232
THR A 210
PRO A 234
 None
 0.84A 1fjaC-4g4iA:
undetectable		 1fjaC-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		3 / 3 THR A 232
THR A 210
PRO A 234
 None
 0.84A 1fjaD-4g4iA:
undetectable		 1fjaD-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		6 / 12 ILE A 128
ALA A 219
ILE A 361
LEU A 365
ILE A 127
THR A 222
 None
 1.49A 1rx7A-4g4iA:
undetectable		 1rx7A-4g4iA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL2_0
(7-AMINO-ACTINOMYCIN
D)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		3 / 3 THR A 210
PRO A 234
THR A 232
 None
 0.87A 1unjL-4g4iA:
undetectable		 1unjL-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE2_0
(7-AMINOACTINOMYCIN D)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		3 / 3 THR A 210
PRO A 234
THR A 232
 None
 0.86A 1unmE-4g4iA:
undetectable		 1unmE-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 7 GLY A 211
THR A 143
ILE A 127
GLY A 129
 None
GOL  A 511 (-3.6A)
None
None
 0.84A 1usqF-4g4iA:
undetectable		 1usqF-4g4iA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 6 SER A 112
ALA A 113
SER A  97
THR A  99
 None
None
None
EDO  A 502 (-4.7A)
 1.21A 1yvpB-4g4iA:
2.4		 1yvpB-4g4iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC8_0
(N8-ACTINOMYCIN D)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		3 / 3 THR A 232
THR A 210
PRO A 234
 None
 0.78A 209dC-4g4iA:
undetectable		 209dC-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		6 / 12 ILE A 128
ALA A 219
ILE A 361
LEU A 365
ILE A 127
THR A 222
 None
 1.49A 2drcB-4g4iA:
undetectable		 2drcB-4g4iA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 7 GLY A 211
THR A 143
ILE A 127
GLY A 129
 None
GOL  A 511 (-3.6A)
None
None
 0.83A 2jkjE-4g4iA:
undetectable		 2jkjE-4g4iA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 7 GLY A 211
THR A 143
ILE A 127
GLY A 129
 None
GOL  A 511 (-3.6A)
None
None
 0.83A 2jklE-4g4iA:
undetectable		 2jklE-4g4iA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 8 LEU A  74
ARG A  67
GLY A 323
MET A 320
 None
 1.00A 2po5A-4g4iA:
undetectable		 2po5A-4g4iA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB926_0
(FERROCHELATASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 10 LEU A  74
ILE A  70
ARG A  67
GLY A 323
MET A 320
 None
 1.09A 2qd4B-4g4iA:
undetectable		 2qd4B-4g4iA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
316D_C_DVAC2_0
(8-FLUORO-ACTINOMYCIN
D)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		3 / 3 THR A 210
PRO A 234
THR A 232
 None
 0.79A 316dC-4g4iA:
undetectable		 316dC-4g4iA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 11 ARG A 214
GLY A 218
GLY A 238
GLN A 235
GLU A 305
 EDO  A 506 (-3.6A)
None
None
None
None
 1.40A 3ag3G-4g4iA:
undetectable
3ag3N-4g4iA:
undetectable
3ag3O-4g4iA:
undetectable		 3ag3G-4g4iA:
12.00
3ag3N-4g4iA:
21.15
3ag3O-4g4iA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 12 ALA A 219
ILE A 233
ILE A 137
PRO A 138
THR A 222
 None
None
GOL  A 511 (-4.1A)
None
None
 0.98A 3clbC-4g4iA:
undetectable		 3clbC-4g4iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 10 ALA A 219
ILE A 233
ILE A 137
PRO A 138
THR A 222
 None
None
GOL  A 511 (-4.1A)
None
None
 1.01A 3clbD-4g4iA:
undetectable		 3clbD-4g4iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 11 ALA A 219
ILE A 233
ILE A 137
PRO A 138
THR A 222
 None
None
GOL  A 511 (-4.1A)
None
None
 0.99A 3hbbC-4g4iA:
undetectable		 3hbbC-4g4iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 10 ALA A 219
ILE A 233
ILE A 137
PRO A 138
THR A 222
 None
None
GOL  A 511 (-4.1A)
None
None
 1.05A 3hbbD-4g4iA:
undetectable		 3hbbD-4g4iA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 10 LEU A  74
ILE A  70
ARG A  67
GLY A 323
MET A 320
 None
 0.99A 3hcpB-4g4iA:
undetectable		 3hcpB-4g4iA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 12 SER A 237
GLY A 216
MET A 336
ILE A 326
LEU A 292
 None
 1.46A 3iizA-4g4iA:
undetectable		 3iizA-4g4iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 9 LEU A 340
PHE A 220
GLY A 323
ALA A 322
ILE A 247
 None
 1.45A 3jusB-4g4iA:
undetectable		 3jusB-4g4iA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		3 / 3 SER A 177
GLY A 152
SER A 159
 None
 0.66A 3loqA-4g4iA:
undetectable		 3loqA-4g4iA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 9 ALA A 113
ILE A 128
VAL A 185
ILE A 202
ILE A 144
 None
 0.98A 3s43A-4g4iA:
undetectable		 3s43A-4g4iA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 211
GLY A 132
ILE A 128
ALA A 213
ARG A 214
 None
None
None
EDO  A 506 ( 4.1A)
EDO  A 506 (-3.6A)
 1.11A 4a6dA-4g4iA:
undetectable		 4a6dA-4g4iA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 211
GLY A 132
ILE A 128
ALA A 213
ARG A 214
 None
None
None
EDO  A 506 ( 4.1A)
EDO  A 506 (-3.6A)
 1.02A 4a6eA-4g4iA:
undetectable		 4a6eA-4g4iA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		3 / 3 PHE A 220
VAL A 303
GLU A 305
 None
 0.79A 4fvqA-4g4iA:
undetectable		 4fvqA-4g4iA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 12 ILE A  98
THR A 222
VAL A 226
ASP A 190
ILE A 189
 None
 1.35A 4i41A-4g4iA:
undetectable		 4i41A-4g4iA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 12 SER A 237
GLY A 216
MET A 336
ILE A 326
LEU A 292
 None
 1.47A 4jxcA-4g4iA:
undetectable		 4jxcA-4g4iA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 7 LEU A 292
ARG A  66
SER A 248
VAL A 285
 None
 1.11A 4klrA-4g4iA:
undetectable		 4klrA-4g4iA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 5 GLY A 238
ILE A 264
LEU A 178
LEU A 301
 None
 0.77A 4o8fA-4g4iA:
undetectable		 4o8fA-4g4iA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 8 LEU A 357
PRO A 350
VAL A 341
HIS A 376
 None
 0.97A 4qknA-4g4iA:
undetectable		 4qknA-4g4iA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 6 ILE A 109
PHE A 169
PHE A 146
THR A 222
 None
 1.27A 5g08A-4g4iA:
undetectable		 5g08A-4g4iA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 6 SER A 248
GLY A 241
ILE A 264
TRP A 245
 None
 1.08A 5j4nA-4g4iA:
undetectable		 5j4nA-4g4iA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 7 LEU A  74
THR A 283
ASP A 249
LEU A 292
 None
 1.13A 5jq7B-4g4iA:
undetectable		 5jq7B-4g4iA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 9 PRO A 118
ILE A 202
GLY A 201
GLY A 122
ALA A 126
 GOL  A 511 ( 3.7A)
None
None
None
None
 0.88A 5o96A-4g4iA:
undetectable
5o96B-4g4iA:
undetectable		 5o96A-4g4iA:
19.82
5o96B-4g4iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		6 / 12 ALA A 219
VAL A 185
LEU A 225
GLY A 131
GLN A 154
GLY A 184
 None
 1.48A 5vcvA-4g4iA:
undetectable		 5vcvA-4g4iA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 10 PRO A 350
HIS A 344
GLY A 208
ILE A 127
ALA A 133
 None
 1.22A 5vyhA-4g4iA:
undetectable		 5vyhA-4g4iA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_1
(RIFAMPIN
MONOOXYGENASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		5 / 12 GLY A 337
MET A 320
THR A 210
GLY A 211
GLY A 216
 None
 1.16A 6brdB-4g4iA:
undetectable		 6brdB-4g4iA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE
(Thermothelomyces
thermophila) 		4 / 6 LEU A 357
PRO A 350
HIS A 344
GLU A 236
 None
 1.07A 6pahA-4g4iA:
undetectable		 6pahA-4g4iA:
21.15