SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 12 ALA A 135
GLY A 110
LEU A 113
THR A 139
LEU A 145
 None
None
None
GLN  A 302 (-4.3A)
None
 1.17A 1jipA-4g4pA:
undetectable		 1jipA-4g4pA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		4 / 7 LEU A 111
LEU A 113
TYR A 152
LEU A 145
 None
 1.10A 1kt3A-4g4pA:
undetectable		 1kt3A-4g4pA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A 111
LEU A 113
VAL A 178
TYR A 152
LEU A 145
 None
 1.26A 1kt6A-4g4pA:
undetectable		 1kt6A-4g4pA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 11 LEU A 111
LEU A 113
VAL A 178
TYR A 152
LEU A 145
 None
 1.23A 1kt7A-4g4pA:
undetectable		 1kt7A-4g4pA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 12 ASN A 223
ILE A 219
GLY A 207
SER A 205
PHE A 107
 None
 1.35A 1q8jA-4g4pA:
undetectable		 1q8jA-4g4pA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		4 / 6 ASP A 108
TYR A 181
TYR A 206
LEU A 111
 None
None
GLN  A 302 (-4.8A)
None
 1.15A 2w98A-4g4pA:
undetectable
2w98B-4g4pA:
undetectable		 2w98A-4g4pA:
20.86
2w98B-4g4pA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 10 TYR A 106
ILE A 238
ILE A  48
GLY A  89
LEU A 226
 None
None
None
GLN  A 302 (-4.9A)
None
 1.11A 3elzB-4g4pA:
undetectable		 3elzB-4g4pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 10 TYR A 106
ILE A 238
ILE A  48
GLY A  89
LEU A 226
 None
None
None
GLN  A 302 (-4.9A)
None
 1.20A 3em0A-4g4pA:
undetectable		 3em0A-4g4pA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		4 / 7 PHE A 107
PHE A  36
SER A 109
TYR A 181
 None
 1.46A 3hggA-4g4pA:
undetectable		 3hggA-4g4pA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 12 LEU A 128
TYR A 125
ILE A 177
ALA A 114
LEU A 196
 None
 0.91A 3n8zB-4g4pA:
undetectable		 3n8zB-4g4pA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 11 GLU A  63
VAL A  64
ILE A  27
ILE A  78
PHE A 208
 None
 1.34A 4drjA-4g4pA:
undetectable		 4drjA-4g4pA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE504_0
(RNA POLYMERASE
3D-POL)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		3 / 3 VAL A 188
GLY A 191
LYS A 193
 None
 0.73A 4k50E-4g4pA:
undetectable		 4k50E-4g4pA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 11 MET A  90
PHE A  71
GLY A  28
ALA A  77
GLY A  70
 None
GLN  A 302 (-3.8A)
None
None
None
 1.20A 4l6v1-4g4pA:
undetectable
4l6v6-4g4pA:
undetectable		 4l6v1-4g4pA:
14.59
4l6v6-4g4pA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 9 ALA A 134
VAL A 133
ILE A 122
LEU A 128
ALA A 168
 None
 0.94A 5nunA-4g4pA:
undetectable		 5nunA-4g4pA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		4 / 4 LEU A 111
GLY A 110
SER A 204
SER A  91
 None
None
None
GLN  A 302 (-2.9A)
 1.28A 5uunA-4g4pA:
undetectable		 5uunA-4g4pA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		4 / 4 LEU A 111
GLY A 110
SER A 204
SER A  91
 None
None
None
GLN  A 302 (-2.9A)
 1.33A 5uunB-4g4pA:
undetectable		 5uunB-4g4pA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN
(Enterococcus
faecalis) 		5 / 10 ALA A 114
LEU A 194
ALA A  34
THR A  32
ALA A 162
 None
 1.31A 6h1lA-4g4pA:
undetectable		 6h1lA-4g4pA:
21.01