SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4g4s PROTEASOME CHAPERONE
1
PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ILE O  52
GLY O 198
ALA P  69
SER P  68
GLY O 147
 None
 1.12A 1kiaA-4g4sO:
undetectable		 1kiaA-4g4sO:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4g4s PROTEASOME CHAPERONE
1
PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ILE O  52
GLY O 198
ALA P  69
SER P  68
GLY O 147
 None
 1.13A 1nbiA-4g4sO:
undetectable		 1nbiA-4g4sO:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4g4s PROTEASOME CHAPERONE
1
PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ILE O  52
GLY O 198
ALA P  69
SER P  68
GLY O 147
 None
 1.12A 1nbiB-4g4sO:
undetectable		 1nbiB-4g4sO:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_2
(GLUCODEXTRANASE)		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae) 		4 / 5 GLN P 250
GLU P  52
LEU P 219
TRP P  21
 None
 1.29A 1ulvA-4g4sP:
undetectable		 1ulvA-4g4sP:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		4 / 5 TRP O 261
ALA O 267
LEU O 260
ALA O 266
 None
 1.05A 2jstA-4g4sO:
undetectable
2jstB-4g4sO:
undetectable		 2jstA-4g4sO:
12.04
2jstB-4g4sO:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 9 GLY O 147
SER O 143
VAL O  33
PRO O  34
VAL O  30
 None
 1.33A 2nnhB-4g4sO:
undetectable		 2nnhB-4g4sO:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		4 / 7 GLN P  85
ARG O 152
LEU P  70
ASP P  37
 None
 1.07A 2qqcB-4g4sP:
undetectable
2qqcC-4g4sP:
undetectable		 2qqcB-4g4sP:
16.36
2qqcC-4g4sP:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		4 / 7 LEU P  70
ASP P  37
GLN P  85
ARG O 152
 None
 1.07A 2qqcG-4g4sP:
undetectable
2qqcJ-4g4sP:
undetectable		 2qqcG-4g4sP:
13.60
2qqcJ-4g4sP:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae) 		5 / 12 LEU P  33
LEU P  80
GLY P  79
MET P   1
PHE P 106
 None
 1.25A 2w8yA-4g4sP:
undetectable		 2w8yA-4g4sP:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 12 ILE O 166
PHE O  61
ALA O 266
ILE O 168
MET O 177
 None
 1.23A 2xkwB-4g4sO:
undetectable		 2xkwB-4g4sO:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae) 		4 / 8 TYR P  74
ASN P  75
LYS P  76
LYS P  77
 None
 1.20A 3bjwD-4g4sP:
undetectable		 3bjwD-4g4sP:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 12 THR O  53
THR O  54
GLU O 137
ILE O 193
LEU O 132
 None
 1.22A 3gwxB-4g4sO:
undetectable		 3gwxB-4g4sO:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae) 		3 / 3 PRO P  88
LEU P  41
GLN P  85
 None
 0.65A 3hznG-4g4sP:
undetectable
3hznH-4g4sP:
undetectable		 3hznG-4g4sP:
20.94
3hznH-4g4sP:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae) 		4 / 8 ASN P  24
GLU P  71
TYR P  59
LEU P  58
 None
 1.08A 3rqwC-4g4sP:
undetectable
3rqwD-4g4sP:
undetectable		 3rqwC-4g4sP:
22.60
3rqwD-4g4sP:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae) 		4 / 8 GLU P  71
TYR P  59
LEU P  58
ASN P  24
 None
 1.07A 3rqwF-4g4sP:
undetectable
3rqwJ-4g4sP:
undetectable		 3rqwF-4g4sP:
22.60
3rqwJ-4g4sP:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae) 		5 / 12 SER P 120
ILE P  14
LEU P 219
GLY P 215
TYR P 253
 None
 1.19A 4foxB-4g4sP:
undetectable		 4foxB-4g4sP:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_G_D16G301_1
(THYMIDYLATE SYNTHASE)		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae) 		5 / 12 SER P 120
ILE P  14
LEU P 219
GLY P 215
TYR P 253
 None
 1.20A 4foxG-4g4sP:
undetectable		 4foxG-4g4sP:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 12 ALA O 219
MET O 177
LEU O 217
GLY O 243
ASP O 240
 None
 1.15A 4qckA-4g4sO:
undetectable		 4qckA-4g4sO:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4g4s PROTEASOME ASSEMBLY
CHAPERONE 2
(Saccharomyces
cerevisiae) 		4 / 6 TYR P  59
ASP P  20
ILE P 247
ARG P  50
 None
 1.38A 5igyA-4g4sP:
undetectable		 5igyA-4g4sP:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 10 ILE O  52
ILE O 165
LEU O 212
ILE O 150
ASN O 148
 None
 1.06A 5vkqA-4g4sO:
undetectable
5vkqD-4g4sO:
undetectable		 5vkqA-4g4sO:
9.86
5vkqD-4g4sO:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 10 ILE O 150
ASN O 148
ILE O  52
ILE O 165
LEU O 212
 None
 1.06A 5vkqA-4g4sO:
undetectable
5vkqB-4g4sO:
undetectable		 5vkqA-4g4sO:
9.86
5vkqB-4g4sO:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 10 ILE O 150
ASN O 148
ILE O  52
ILE O 165
LEU O 212
 None
 1.04A 5vkqC-4g4sO:
undetectable
5vkqD-4g4sO:
undetectable		 5vkqC-4g4sO:
9.86
5vkqD-4g4sO:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 10 PHE O  38
GLY O  72
ILE O 124
ILE O 154
ILE O 150
 None
 1.06A 6ebpD-4g4sO:
undetectable		 6ebpD-4g4sO:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 11 PHE O  38
GLY O  72
ILE O 124
ILE O 154
ILE O 150
 None
 1.05A 6ebzC-4g4sO:
undetectable		 6ebzC-4g4sO:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 11 PHE O  38
GLY O  72
ILE O 124
ILE O 154
ILE O 150
 None
 1.08A 6ebzD-4g4sO:
undetectable		 6ebzD-4g4sO:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 4g4s PROTEASOME CHAPERONE
1
(Saccharomyces
cerevisiae) 		5 / 11 PHE O  38
GLY O  72
ILE O 124
ILE O 154
ILE O 150
 None
 0.98A 6gp2B-4g4sO:
undetectable		 6gp2B-4g4sO:
12.77