SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g54'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 8 TYR A 363
LEU A 454
ASP A 453
THR A 382
 None
 0.92A 1rmtD-4g54A:
undetectable		 1rmtD-4g54A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_A_RBFA200_1
(DODECIN)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 8 ARG A 523
ARG A 460
GLN A 525
GLN A 388
 None
 1.40A 2vxaA-4g54A:
undetectable
2vxaC-4g54A:
undetectable
2vxaE-4g54A:
undetectable		 2vxaA-4g54A:
14.17
2vxaC-4g54A:
14.17
2vxaE-4g54A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_B_RBFB200_1
(DODECIN)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 8 ARG A 460
GLN A 525
ARG A 523
GLN A 388
 None
 1.44A 2vxaA-4g54A:
undetectable
2vxaB-4g54A:
undetectable
2vxaK-4g54A:
undetectable		 2vxaA-4g54A:
14.17
2vxaB-4g54A:
14.17
2vxaK-4g54A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_C_RBFC200_1
(DODECIN)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 8 ARG A 460
GLN A 525
ARG A 523
GLN A 388
 None
 1.41A 2vxaB-4g54A:
undetectable
2vxaC-4g54A:
undetectable
2vxaG-4g54A:
undetectable		 2vxaB-4g54A:
14.17
2vxaC-4g54A:
14.17
2vxaG-4g54A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_D_RBFD200_1
(DODECIN)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 8 ARG A 523
ARG A 460
GLN A 525
GLN A 388
 None
 1.42A 2vxaD-4g54A:
undetectable
2vxaF-4g54A:
undetectable
2vxaI-4g54A:
undetectable		 2vxaD-4g54A:
14.17
2vxaF-4g54A:
14.17
2vxaI-4g54A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_H_RBFH200_1
(DODECIN)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 8 GLN A 388
ARG A 460
GLN A 525
ARG A 523
 None
 1.40A 2vxaB-4g54A:
undetectable
2vxaG-4g54A:
undetectable
2vxaH-4g54A:
undetectable		 2vxaB-4g54A:
14.17
2vxaG-4g54A:
14.17
2vxaH-4g54A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_I_RBFI200_1
(DODECIN)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 8 ARG A 460
GLN A 525
ARG A 523
GLN A 388
 None
 1.42A 2vxaH-4g54A:
undetectable
2vxaI-4g54A:
undetectable
2vxaJ-4g54A:
undetectable		 2vxaH-4g54A:
14.17
2vxaI-4g54A:
14.17
2vxaJ-4g54A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_K_RBFK200_1
(DODECIN)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 8 GLN A 388
ARG A 460
GLN A 525
ARG A 523
 None
 1.43A 2vxaH-4g54A:
undetectable
2vxaJ-4g54A:
undetectable
2vxaK-4g54A:
undetectable		 2vxaH-4g54A:
14.17
2vxaJ-4g54A:
14.17
2vxaK-4g54A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_L_RBFL200_1
(DODECIN)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 8 GLN A 388
ARG A 460
GLN A 525
ARG A 523
 None
 1.42A 2vxaA-4g54A:
undetectable
2vxaK-4g54A:
undetectable
2vxaL-4g54A:
undetectable		 2vxaA-4g54A:
14.17
2vxaK-4g54A:
14.17
2vxaL-4g54A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		5 / 12 LEU A 479
GLN A 505
LEU A 459
LEU A 521
GLY A 517
 None
 1.37A 3g1uB-4g54A:
undetectable		 3g1uB-4g54A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 6 GLN A 499
LEU A 497
GLU A 496
LEU A 488
 None
 0.86A 3h5gA-4g54A:
undetectable
3h5gC-4g54A:
undetectable		 3h5gA-4g54A:
8.13
3h5gC-4g54A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 8 GLN A 539
VAL A 428
THR A 437
ARG A 426
 None
 1.04A 4lnwA-4g54A:
undetectable		 4lnwA-4g54A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 6 GLN A 539
VAL A 428
THR A 437
ARG A 426
 None
 1.17A 4lnxA-4g54A:
undetectable		 4lnxA-4g54A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4g54 GENERAL SECRETION
PATHWAY PROTEIN
(Vibrio
vulnificus) 		4 / 6 ALA A 516
GLN A 505
LEU A 521
LEU A 479
 None
 1.15A 4xoyA-4g54A:
undetectable		 4xoyA-4g54A:
20.06