SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g56'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 12 VAL A  78
GLY A  79
LEU A 118
VAL A 261
PHE A  35
 None
 1.47A 1a27A-4g56A:
2.3		 1a27A-4g56A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4001_1
(SERUM ALBUMIN)		 4g56 HSL7 PROTEIN
MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 4 ARG A  44
LYS B 135
ASP B  89
GLY B  91
 None
 1.17A 1e7bB-4g56A:
0.0		 1e7bB-4g56A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 4g56 HSL7 PROTEIN
MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 5 ARG A  44
LYS B 135
ASP B  89
GLY B  91
 None
 1.14A 1e7cA-4g56A:
undetectable		 1e7cA-4g56A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		3 / 3 GLN A 259
ILE A 231
HIS A 246
 None
 0.55A 1fm9A-4g56A:
undetectable		 1fm9A-4g56A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 12 LEU A 133
LEU A 132
HIS A 186
LEU A 121
ILE A 119
 None
 1.25A 1fmlA-4g56A:
undetectable		 1fmlA-4g56A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		3 / 3 GLN A 259
ILE A 231
HIS A 246
 None
 0.56A 1k74A-4g56A:
undetectable		 1k74A-4g56A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		4 / 6 PHE A 505
ALA A 548
ILE A 563
PRO A 577
 None
 1.23A 1oniH-4g56A:
undetectable
1oniI-4g56A:
1.5		 1oniH-4g56A:
11.42
1oniI-4g56A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		4 / 6 TYR A 464
HIS A 519
GLU A 440
PRO A 310
 None
None
SAH  A 701 (-2.5A)
None
 1.31A 1q13A-4g56A:
4.2		 1q13A-4g56A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		4 / 7 GLY A 205
PRO A 155
ASP A 157
THR A 181
 None
 0.93A 2aouB-4g56A:
9.3		 2aouB-4g56A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 12 ILE A 222
LEU A 121
VAL A 150
GLU A 220
ARG A 189
 None
 1.22A 2bxfA-4g56A:
undetectable		 2bxfA-4g56A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_B_GBNB420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		5 / 9 VAL B 118
THR B  74
GLY B  46
THR B  69
ALA B  71
 None
 1.33A 2cojA-4g56B:
undetectable
2cojB-4g56B:
undetectable		 2cojA-4g56B:
21.12
2cojB-4g56B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 5 ALA B  23
ALA B 252
ALA B 262
VAL B 270
 None
 0.86A 2nyrB-4g56B:
undetectable		 2nyrB-4g56B:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4g56 HSL7 PROTEIN
MGC81050 PROTEIN
(Xenopus
laevis) 		3 / 3 ASP A 160
TYR B 153
LYS B 140
 None
 1.14A 2othA-4g56A:
undetectable		 2othA-4g56A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 12 GLY A 363
PRO A 366
ASN A 390
ASP A 415
LEU A 432
 SAH  A 701 ( 4.1A)
None
None
SAH  A 701 (-2.8A)
SAH  A 701 (-4.5A)
 0.92A 2zzmA-4g56A:
8.9		 2zzmA-4g56A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 7 VAL B  24
HIS B 314
LEU B  34
ILE B 264
 None
 1.04A 3avpA-4g56B:
undetectable		 3avpA-4g56B:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 4g56 HSL7 PROTEIN
MGC81050 PROTEIN
(Xenopus
laevis) 		3 / 3 ARG A  93
VAL B 290
THR B 249
 None
 0.87A 3cyxA-4g56A:
undetectable		 3cyxA-4g56A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 6 ALA B 294
SER B 296
THR B 304
VAL B 306
 None
 0.88A 3d2tB-4g56B:
undetectable		 3d2tB-4g56B:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		3 / 3 ILE A 134
PHE A 188
HIS A 136
 None
 0.75A 3h0aA-4g56A:
undetectable		 3h0aA-4g56A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 4g56 HSL7 PROTEIN
MGC81050 PROTEIN
(Xenopus
laevis;
Xenopus
laevis) 		4 / 6 SER B 138
PHE B 137
ASP B 116
PRO A 155
 None
 1.33A 3jqaA-4g56B:
undetectable		 3jqaA-4g56B:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4g56 HSL7 PROTEIN
MGC81050 PROTEIN
(Xenopus
laevis;
Xenopus
laevis) 		4 / 6 SER B 138
PHE B 137
ASP B 116
PRO A 155
 None
 1.37A 3jqaB-4g56B:
undetectable		 3jqaB-4g56B:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		4 / 6 ARG A 364
GLY A 365
GLU A 321
GLU A 324
 None
 0.99A 3k9fA-4g56A:
undetectable
3k9fB-4g56A:
undetectable
3k9fD-4g56A:
1.8		 3k9fA-4g56A:
21.40
3k9fB-4g56A:
21.40
3k9fD-4g56A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		3 / 3 GLN B  68
THR B  69
LEU B  39
 None
 0.60A 3ondA-4g56B:
undetectable		 3ondA-4g56B:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		3 / 3 GLN B  68
THR B  69
LEU B  39
 None
 0.60A 3ondB-4g56B:
undetectable		 3ondB-4g56B:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4g56 HSL7 PROTEIN
MGC81050 PROTEIN
(Xenopus
laevis;
Xenopus
laevis) 		3 / 3 HIS B 114
SER A 230
ASN B 154
 None
 0.82A 3s8pB-4g56B:
undetectable		 3s8pB-4g56B:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 6 HIS B 156
GLU B 178
ASP B 179
PRO B 205
 None
 1.37A 4apjA-4g56B:
undetectable
4apjP-4g56B:
undetectable		 4apjA-4g56B:
20.51
4apjP-4g56B:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 4g56 HSL7 PROTEIN
MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 5 SER A 265
HIS B 114
TYR B 112
VAL B 118
 None
 1.31A 4eohB-4g56A:
undetectable		 4eohB-4g56A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 5 SER B 152
HIS B 156
VAL B 160
ASP B 136
 None
 1.42A 4eohB-4g56B:
undetectable		 4eohB-4g56B:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD302_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		3 / 3 TYR A 609
PHE A 517
ARG A 600
 None
 1.24A 4g19D-4g56A:
undetectable		 4g19D-4g56A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		3 / 3 HIS B 244
GLY B 250
ILE B 248
 None
 0.63A 4k50A-4g56B:
undetectable		 4k50A-4g56B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 6 ILE B 264
GLY B 307
VAL B 312
HIS B 315
 None
 0.91A 4oltB-4g56B:
undetectable		 4oltB-4g56B:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 4g56 HSL7 PROTEIN
MGC81050 PROTEIN
(Xenopus
laevis;
Xenopus
laevis) 		3 / 3 LYS B 135
LYS A  80
ALA A  16
 None
 1.50A 4ot2A-4g56B:
undetectable		 4ot2A-4g56B:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		10 / 12 GLY A 361
GLY A 363
LEU A 367
LYS A 389
ASN A 390
MET A 416
ARG A 417
GLU A 431
LEU A 432
CYH A 445
 SAH  A 701 (-3.3A)
SAH  A 701 ( 4.1A)
None
SAH  A 701 (-4.0A)
None
SAH  A 701 (-4.3A)
SAH  A 701 ( 4.7A)
SAH  A 701 (-3.1A)
SAH  A 701 (-4.5A)
SAH  A 701 (-3.4A)
 0.49A 4x61A-4g56A:
40.2		 4x61A-4g56A:
80.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		10 / 12 GLY A 361
GLY A 363
PRO A 366
LEU A 367
LYS A 389
ASN A 390
MET A 416
GLU A 431
LEU A 432
CYH A 445
 SAH  A 701 (-3.3A)
SAH  A 701 ( 4.1A)
None
None
SAH  A 701 (-4.0A)
None
SAH  A 701 (-4.3A)
SAH  A 701 (-3.1A)
SAH  A 701 (-4.5A)
SAH  A 701 (-3.4A)
 0.56A 4x61A-4g56A:
40.2		 4x61A-4g56A:
80.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		9 / 12 LEU A 311
GLY A 361
GLY A 363
LYS A 389
ASN A 390
MET A 416
ARG A 417
GLU A 431
CYH A 445
 SAH  A 701 (-4.1A)
SAH  A 701 (-3.3A)
SAH  A 701 ( 4.1A)
SAH  A 701 (-4.0A)
None
SAH  A 701 (-4.3A)
SAH  A 701 ( 4.7A)
SAH  A 701 (-3.1A)
SAH  A 701 (-3.4A)
 0.64A 4x61A-4g56A:
40.2		 4x61A-4g56A:
80.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		9 / 12 LEU A 311
GLY A 361
GLY A 363
PRO A 366
LYS A 389
ASN A 390
MET A 416
GLU A 431
CYH A 445
 SAH  A 701 (-4.1A)
SAH  A 701 (-3.3A)
SAH  A 701 ( 4.1A)
None
SAH  A 701 (-4.0A)
None
SAH  A 701 (-4.3A)
SAH  A 701 (-3.1A)
SAH  A 701 (-3.4A)
 0.68A 4x61A-4g56A:
40.2		 4x61A-4g56A:
80.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		3 / 3 VAL B 293
PHE B 281
ARG B 282
 None
 0.85A 4xr4B-4g56B:
undetectable		 4xr4B-4g56B:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 12 VAL A 384
VAL A 409
LEU A 372
ALA A 370
TRP A 405
 None
 1.32A 4yhaA-4g56A:
undetectable		 4yhaA-4g56A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 12 VAL A 384
VAL A 409
LEU A 372
ALA A 370
TRP A 405
 None
 1.19A 4yhaG-4g56A:
undetectable		 4yhaG-4g56A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4g56 HSL7 PROTEIN
MGC81050 PROTEIN
(Xenopus
laevis;
Xenopus
laevis) 		3 / 3 HIS B 114
SER A 230
ASN B 154
 None
 0.76A 5cprB-4g56B:
undetectable		 5cprB-4g56B:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 5 GLU B  70
ALA B  92
GLU B  94
ASN B 107
 None
 1.35A 5dwkC-4g56B:
undetectable		 5dwkC-4g56B:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 6 PHE B 281
SER B 263
HIS B 244
LEU B 273
 None
 1.39A 5dzka-4g56B:
undetectable
5dzko-4g56B:
undetectable		 5dzka-4g56B:
21.88
5dzko-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 5 SER B 263
ALA B 262
HIS B 244
LEU B 273
 None
 1.47A 5dzkb-4g56B:
undetectable
5dzkp-4g56B:
undetectable		 5dzkb-4g56B:
21.88
5dzkp-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 6 PHE B 281
SER B 263
ALA B 262
HIS B 244
 None
 1.03A 5dzkB-4g56B:
undetectable
5dzkP-4g56B:
undetectable		 5dzkB-4g56B:
21.88
5dzkP-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 5 SER B 263
ALA B 262
HIS B 244
LEU B 273
 None
 1.46A 5dzkc-4g56B:
undetectable
5dzkq-4g56B:
undetectable		 5dzkc-4g56B:
21.88
5dzkq-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		5 / 7 PHE B 281
SER B 263
ALA B 262
HIS B 244
LEU B 273
 None
 1.21A 5dzkD-4g56B:
undetectable
5dzkR-4g56B:
undetectable		 5dzkD-4g56B:
21.88
5dzkR-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 8 PHE B 281
SER B 263
ALA B 262
HIS B 244
 None
 1.03A 5dzkd-4g56B:
undetectable
5dzkr-4g56B:
undetectable		 5dzkd-4g56B:
21.88
5dzkr-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 5 SER B 263
ALA B 262
HIS B 244
LEU B 273
 None
 1.25A 5dzkf-4g56B:
undetectable
5dzkt-4g56B:
undetectable		 5dzkf-4g56B:
21.88
5dzkt-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 8 PHE B 281
SER B 263
ALA B 262
HIS B 244
 None
 1.02A 5dzkF-4g56B:
undetectable
5dzkT-4g56B:
undetectable		 5dzkF-4g56B:
21.88
5dzkT-4g56B:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		5 / 6 PHE B 281
SER B 263
ALA B 262
HIS B 244
LEU B 273
 None
 1.38A 5dzkg-4g56B:
undetectable
5dzku-4g56B:
undetectable		 5dzkg-4g56B:
21.88
5dzku-4g56B:
3.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		11 / 12 PRO A 310
LEU A 311
GLY A 363
LEU A 367
LYS A 389
ASN A 390
MET A 416
ARG A 417
GLU A 431
LEU A 432
CYH A 445
 None
SAH  A 701 (-4.1A)
SAH  A 701 ( 4.1A)
None
SAH  A 701 (-4.0A)
None
SAH  A 701 (-4.3A)
SAH  A 701 ( 4.7A)
SAH  A 701 (-3.1A)
SAH  A 701 (-4.5A)
SAH  A 701 (-3.4A)
 0.47A 5emlA-4g56A:
48.6		 5emlA-4g56A:
80.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		11 / 12 PRO A 310
LEU A 311
GLY A 363
PRO A 366
LEU A 367
LYS A 389
ASN A 390
MET A 416
GLU A 431
LEU A 432
CYH A 445
 None
SAH  A 701 (-4.1A)
SAH  A 701 ( 4.1A)
None
None
SAH  A 701 (-4.0A)
None
SAH  A 701 (-4.3A)
SAH  A 701 (-3.1A)
SAH  A 701 (-4.5A)
SAH  A 701 (-3.4A)
 0.53A 5emlA-4g56A:
48.6		 5emlA-4g56A:
80.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		4 / 6 TYR A 320
GLY A 361
GLU A 388
ASP A 415
 SAH  A 701 (-4.3A)
SAH  A 701 (-3.3A)
SAH  A 701 (-2.5A)
SAH  A 701 (-2.8A)
 0.48A 5emlA-4g56A:
48.4		 5emlA-4g56A:
80.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 12 VAL A 429
PRO A 366
LEU A 433
SER A 442
LEU A 397
 None
 1.11A 5hv1A-4g56A:
undetectable		 5hv1A-4g56A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		5 / 12 LEU B 184
ALA B 193
ILE B 196
ASP B 179
SER B 175
 None
 1.07A 5nfjB-4g56B:
undetectable		 5nfjB-4g56B:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		4 / 6 LEU B 317
SER B 301
PHE B 303
HIS B 314
 None
 1.22A 5om3A-4g56B:
undetectable
5om3B-4g56B:
undetectable		 5om3A-4g56B:
14.93
5om3B-4g56B:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 9 VAL A 384
VAL A 409
LEU A 372
ALA A 370
TRP A 405
 None
 1.29A 5tt3G-4g56A:
undetectable		 5tt3G-4g56A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		4 / 4 LEU A 561
LEU A 555
SER A 331
ALA A 336
 None
 1.01A 5uunA-4g56A:
undetectable		 5uunA-4g56A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4g56 MGC81050 PROTEIN
(Xenopus
laevis) 		5 / 12 ALA B 164
LEU B 174
VAL B 160
GLY B 177
THR B 203
 None
 1.07A 5x24A-4g56B:
undetectable		 5x24A-4g56B:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 12 ARG A 488
PRO A 307
LEU A 468
ASN A 623
PHE A 598
 None
 1.41A 5ybbB-4g56A:
6.0		 5ybbB-4g56A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		3 / 3 GLN A 259
ILE A 231
HIS A 246
 None
 0.59A 5z12B-4g56A:
undetectable		 5z12B-4g56A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 12 GLY A 361
GLY A 363
ASN A 390
ALA A 393
ASP A 415
 SAH  A 701 (-3.3A)
SAH  A 701 ( 4.1A)
None
None
SAH  A 701 (-2.8A)
 0.67A 6b3aA-4g56A:
8.5		 6b3aA-4g56A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		5 / 12 GLY A 361
GLY A 363
ASN A 390
ALA A 393
ASP A 415
 SAH  A 701 (-3.3A)
SAH  A 701 ( 4.1A)
None
None
SAH  A 701 (-2.8A)
 0.66A 6b3bA-4g56A:
8.4		 6b3bA-4g56A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4g56 HSL7 PROTEIN
(Xenopus
laevis) 		4 / 4 LEU A 129
ASP A  88
GLN A 123
VAL A  15
 None
 1.44A 6bzoF-4g56A:
undetectable		 6bzoF-4g56A:
23.03