SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 6 MET C 221
LYS C 219
ALA C 233
LEU C 235
 None
 0.86A 1etb1-4g59C:
undetectable		 1etb1-4g59C:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		5 / 12 GLU C 140
VAL C 138
PHE C  78
PHE C  87
PHE C  95
 None
 1.03A 1nw3A-4g59C:
undetectable		 1nw3A-4g59C:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 6 LYS C 219
ALA C 233
LEU C 235
SER C 188
 None
 0.86A 1tz8C-4g59C:
undetectable
1tz8D-4g59C:
undetectable		 1tz8C-4g59C:
17.32
1tz8D-4g59C:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		3 / 3 ARG C 180
VAL C 174
THR C 254
 None
 0.71A 2nmzA-4g59C:
undetectable		 2nmzA-4g59C:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 8 ILE C 209
VAL C 249
TYR C 184
CYH C 197
 None
 1.00A 2xz5A-4g59C:
undetectable
2xz5C-4g59C:
undetectable		 2xz5A-4g59C:
20.36
2xz5C-4g59C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 8 ILE C 209
VAL C 249
TYR C 184
CYH C 197
 None
 1.26A 2xz5A-4g59C:
undetectable
2xz5C-4g59C:
undetectable		 2xz5A-4g59C:
20.36
2xz5C-4g59C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 8 ILE C 209
VAL C 249
TYR C 184
CYH C 197
 None
 0.99A 2xz5C-4g59C:
undetectable
2xz5D-4g59C:
undetectable		 2xz5C-4g59C:
20.36
2xz5D-4g59C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 8 ILE C 209
VAL C 249
TYR C 184
CYH C 197
 None
 1.28A 2xz5C-4g59C:
undetectable
2xz5D-4g59C:
undetectable		 2xz5C-4g59C:
20.36
2xz5D-4g59C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 7 ILE C 209
VAL C 249
TYR C 184
CYH C 197
 None
 1.28A 2xz5D-4g59C:
undetectable
2xz5E-4g59C:
undetectable		 2xz5D-4g59C:
20.36
2xz5E-4g59C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		3 / 3 ARG C 180
VAL C 174
THR C 254
 None
 0.80A 3k4vD-4g59C:
undetectable		 3k4vD-4g59C:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 8 PHE C  71
GLN C  75
ARG C  77
PHE C  78
 None
 1.17A 3mjrD-4g59C:
undetectable		 3mjrD-4g59C:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 4g59 M152 PROTEIN
RETINOIC ACID
EARLY-INDUCIBLE
PROTEIN 1-GAMMA
(Murid
betaherpesvirus
1;
Mus
musculus) 		4 / 5 ILE C 209
ARG C 200
THR C 198
GLU A 159
 None
 1.31A 3ny4A-4g59C:
undetectable		 3ny4A-4g59C:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 8 VAL C  86
ARG C  91
VAL C  93
MET C 112
 None
 1.01A 3remB-4g59C:
undetectable		 3remB-4g59C:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 8 VAL C 249
TYR C 184
CYH C 197
ILE C 209
 None
 0.94A 4aftD-4g59C:
undetectable
4aftE-4g59C:
undetectable		 4aftD-4g59C:
20.36
4aftE-4g59C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 8 VAL C 249
TYR C 184
CYH C 197
ILE C 209
 None
 0.90A 4bqtC-4g59C:
undetectable
4bqtD-4g59C:
undetectable		 4bqtC-4g59C:
20.36
4bqtD-4g59C:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 4g59 RETINOIC ACID
EARLY-INDUCIBLE
PROTEIN 1-GAMMA
(Mus
musculus) 		4 / 8 LEU A  68
CYH A  69
TYR A  22
PRO A  64
 None
 1.05A 4j7uD-4g59A:
undetectable		 4j7uD-4g59A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		5 / 11 TYR C  82
ASP C 142
VAL C 126
GLY C 149
THR C 128
 None
 1.26A 4mmaA-4g59C:
undetectable		 4mmaA-4g59C:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 4g59 M152 PROTEIN
RETINOIC ACID
EARLY-INDUCIBLE
PROTEIN 1-GAMMA
(Murid
betaherpesvirus
1;
Mus
musculus) 		4 / 5 LEU A  20
GLU C  28
LEU A   9
HIS A  91
 None
 1.17A 4xi3B-4g59A:
1.6		 4xi3B-4g59A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 7 PHE C  78
PHE C  95
GLY C 147
THR C 118
 None
 0.91A 4zdzA-4g59C:
undetectable		 4zdzA-4g59C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 7 PHE C  78
PHE C  95
GLY C 147
THR C 118
 None
 0.90A 4ze3A-4g59C:
undetectable		 4ze3A-4g59C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 4g59 RETINOIC ACID
EARLY-INDUCIBLE
PROTEIN 1-GAMMA
(Mus
musculus) 		3 / 3 ASN A 126
SER A 128
ARG A 130
 None
 0.94A 5b2qA-4g59A:
undetectable		 5b2qA-4g59A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 8 PHE C  78
PHE C  95
GLY C 147
THR C 118
 None
 0.84A 5esfA-4g59C:
undetectable		 5esfA-4g59C:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 8 PHE C  78
PHE C  95
GLY C 147
THR C 118
 None
 0.89A 5esjA-4g59C:
undetectable		 5esjA-4g59C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 7 PHE C  78
PHE C  95
GLY C 147
THR C 118
 None
 0.89A 5esmA-4g59C:
undetectable		 5esmA-4g59C:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		4 / 5 PHE C 169
ILE C  45
MET C  60
ARG C 165
 None
 1.26A 5jm4A-4g59C:
undetectable		 5jm4A-4g59C:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 4g59 M152 PROTEIN
(Murid
betaherpesvirus
1) 		3 / 3 PHE C  78
ARG C  77
GLN C  75
 None
 0.92A 6g1pB-4g59C:
undetectable		 6g1pB-4g59C:
21.96