SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  89
HIS A  68
ASP A 228
LEU A  66
GLY A  70
 None
 1.33A 1d4fA-4g6bA:
undetectable		 1d4fA-4g6bA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  89
HIS A  68
ASP A 228
LEU A  66
GLY A  70
 None
 1.36A 1d4fC-4g6bA:
undetectable		 1d4fC-4g6bA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		4 / 7 HIS A 226
LEU A 369
SER A 365
ASP A 362
 None
 1.26A 1ismB-4g6bA:
undetectable		 1ismB-4g6bA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 388
GLY A 390
HIS A 394
VAL A 238
ALA A 161
 None
 1.08A 1likA-4g6bA:
undetectable		 1likA-4g6bA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		3 / 3 GLY A 195
GLU A 216
ASN A 199
 None
 0.73A 1zq9A-4g6bA:
undetectable		 1zq9A-4g6bA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		3 / 3 PRO A 313
GLY A  64
TYR A 311
 None
 0.58A 2vouA-4g6bA:
undetectable		 2vouA-4g6bA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		3 / 3 PRO A 313
GLY A  64
TYR A 311
 None
 0.69A 2vouB-4g6bA:
undetectable		 2vouB-4g6bA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		3 / 3 PRO A 313
GLY A  64
TYR A 311
 None
 0.69A 2vouC-4g6bA:
undetectable		 2vouC-4g6bA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 215
GLY A 366
LEU A 369
LEU A 329
CYH A 322
 None
 0.90A 3e23A-4g6bA:
undetectable		 3e23A-4g6bA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  89
HIS A  68
ASP A 228
LEU A  66
GLY A  70
 None
 1.41A 3g1uC-4g6bA:
undetectable		 3g1uC-4g6bA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  89
HIS A  68
ASP A 228
LEU A  66
GLY A  70
 None
 1.33A 3glqA-4g6bA:
undetectable		 3glqA-4g6bA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  89
HIS A  68
ASP A 228
LEU A  66
GLY A  70
 None
 1.38A 3glqB-4g6bA:
undetectable		 3glqB-4g6bA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  89
HIS A  68
ASP A 228
LEU A  66
GLY A  70
 None
 1.26A 3n58A-4g6bA:
undetectable		 3n58A-4g6bA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		4 / 6 ASP A 334
LEU A 335
ALA A 371
LEU A 329
 None
 1.08A 3rozA-4g6bA:
undetectable		 3rozA-4g6bA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		3 / 3 HIS A 226
TRP A 391
SER A 365
 None
 1.07A 4lrhD-4g6bA:
undetectable		 4lrhD-4g6bA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 141
ILE A 117
ALA A 172
ILE A 256
VAL A 133
 None
 0.99A 4nkxC-4g6bA:
undetectable		 4nkxC-4g6bA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A 141
ILE A 117
ALA A 172
ILE A 256
VAL A 133
 None
 0.98A 4nkxD-4g6bA:
undetectable		 4nkxD-4g6bA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		4 / 4 ALA A 250
ALA A 253
ALA A 254
ALA A 257
 None
 0.09A 4oadA-4g6bA:
undetectable		 4oadA-4g6bA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		4 / 4 ALA A 250
ALA A 253
ALA A 254
ALA A 257
 None
 0.10A 4oaeA-4g6bA:
undetectable		 4oaeA-4g6bA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 11 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.96A 4qvlK-4g6bA:
undetectable
4qvlL-4g6bA:
undetectable		 4qvlK-4g6bA:
17.88
4qvlL-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 11 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.95A 4qvlY-4g6bA:
undetectable
4qvlZ-4g6bA:
undetectable		 4qvlY-4g6bA:
17.88
4qvlZ-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 9 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.96A 4qvmK-4g6bA:
undetectable
4qvmL-4g6bA:
undetectable		 4qvmK-4g6bA:
19.06
4qvmL-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.96A 4qvmY-4g6bA:
undetectable
4qvmZ-4g6bA:
undetectable		 4qvmY-4g6bA:
19.06
4qvmZ-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.96A 4qvpK-4g6bA:
undetectable
4qvpL-4g6bA:
undetectable		 4qvpK-4g6bA:
17.88
4qvpL-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.96A 4qvpY-4g6bA:
undetectable
4qvpZ-4g6bA:
undetectable		 4qvpY-4g6bA:
17.88
4qvpZ-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 11 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.94A 4qw1K-4g6bA:
undetectable
4qw1L-4g6bA:
undetectable		 4qw1K-4g6bA:
18.35
4qw1L-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.94A 4qw1Y-4g6bA:
undetectable
4qw1Z-4g6bA:
undetectable		 4qw1Y-4g6bA:
18.35
4qw1Z-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.96A 4qw3K-4g6bA:
undetectable
4qw3L-4g6bA:
undetectable		 4qw3K-4g6bA:
18.82
4qw3L-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 10 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.97A 4qw3Y-4g6bA:
undetectable
4qw3Z-4g6bA:
undetectable		 4qw3Y-4g6bA:
18.82
4qw3Z-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 PHE A 103
ILE A 224
LEU A 165
LEU A  90
LEU A  89
 None
 1.31A 4xumA-4g6bA:
undetectable		 4xumA-4g6bA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 11 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.96A 5bxnK-4g6bA:
undetectable
5bxnL-4g6bA:
undetectable		 5bxnK-4g6bA:
17.88
5bxnL-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 11 THR A 138
ALA A 250
ALA A 246
GLY A 255
ALA A 254
 None
 0.96A 5bxnY-4g6bA:
undetectable
5bxnZ-4g6bA:
undetectable		 5bxnY-4g6bA:
17.88
5bxnZ-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  89
HIS A  68
ASP A 228
LEU A  66
GLY A  70
 None
 1.39A 6aphA-4g6bA:
undetectable		 6aphA-4g6bA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		5 / 12 LEU A  89
HIS A  68
ASP A 228
LEU A  66
GLY A  70
 None
 1.33A 6gbnB-4g6bA:
undetectable		 6gbnB-4g6bA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 4g6b CITRATE SYNTHASE
(Escherichia
coli) 		4 / 5 HIS A 229
ARG A 314
ASP A 362
ARG A 387
 SO4  A 503 (-3.9A)
SO4  A 503 (-3.3A)
None
SO4  A 503 (-3.2A)
 0.61A 6hxiD-4g6bA:
3.7		 6hxiD-4g6bA:
21.67