SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g6c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
4 / 6 ASN A  29
VAL A 281
ALA A 270
LEU A 274
None
0.74A 1e7bB-4g6cA:
undetectable
1e7bB-4g6cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HBP_A_RTLA184_0
(RETINOL BINDING
PROTEIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 11 LEU A 337
ALA A 318
ALA A 163
TYR A 330
GLN A 334
None
1.00A 1hbpA-4g6cA:
undetectable
1hbpA-4g6cA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 9 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.92A 1hpvA-4g6cA:
undetectable
1hpvA-4g6cA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 11 LEU A 337
ALA A 318
ALA A 163
TYR A 330
GLN A 334
None
1.02A 1iiuA-4g6cA:
undetectable
1iiuA-4g6cA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 LEU A 337
ALA A 318
ALA A 163
TYR A 330
GLN A 334
None
1.07A 1kt4A-4g6cA:
undetectable
1kt4A-4g6cA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ALA A 273
PHE A 231
ALA A 269
LEU A  10
HIS A 218
None
1.29A 1rbpA-4g6cA:
undetectable
1rbpA-4g6cA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 11 PHE A 142
LEU A 152
ALA A 340
ALA A  99
VAL A 148
None
1.07A 1rlbF-4g6cA:
undetectable
1rlbF-4g6cA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ALA A 273
GLY A 277
SER A 232
ALA A 269
SER A 252
None
0.96A 1ve3B-4g6cA:
undetectable
1ve3B-4g6cA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 LEU A  35
ALA A  63
ARG A  54
LEU A  10
CYH A 284
None
0.96A 1ya3C-4g6cA:
undetectable
1ya3C-4g6cA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDD_A_AZMA264_1
(CARBONIC ANHYDRASE
II)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 10 GLN A 286
VAL A 283
ARG A 261
THR A 267
THR A 265
None
1.48A 1yddA-4g6cA:
undetectable
1yddA-4g6cA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.86A 2avvB-4g6cA:
undetectable
2avvB-4g6cA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_2
(POL POLYPROTEIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.91A 2f81B-4g6cA:
undetectable
2f81B-4g6cA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 TYR A 204
LEU A 240
HIS A 171
ALA A 166
CYH A 168
None
1.38A 2g70A-4g6cA:
undetectable
2g70A-4g6cA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.92A 2ienB-4g6cA:
undetectable
2ienB-4g6cA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
4 / 6 ARG A  54
ASP A  51
THR A  50
ASP A 120
None
1.05A 2j2pE-4g6cA:
undetectable
2j2pF-4g6cA:
undetectable
2j2pE-4g6cA:
21.51
2j2pF-4g6cA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 9 GLY A 107
LEU A 162
THR A 104
ALA A 105
LEU A 336
None
1.21A 2npnA-4g6cA:
undetectable
2npnA-4g6cA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 9 GLY A 159
THR A 104
ALA A 103
LEU A  82
LEU A 152
None
1.30A 2npnA-4g6cA:
undetectable
2npnA-4g6cA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
4 / 5 PRO A  28
ALA A  26
ASP A 279
ASP A  59
None
1.15A 2nyuB-4g6cA:
undetectable
2nyuB-4g6cA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.92A 2z54B-4g6cA:
undetectable
2z54B-4g6cA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.89A 3d1zB-4g6cA:
undetectable
3d1zB-4g6cA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D20_A_017A201_2
(HIV-1 PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.92A 3d20B-4g6cA:
undetectable
3d20B-4g6cA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 GLY A 164
SER A 161
GLY A 159
GLY A 107
ALA A 314
None
0.91A 3douA-4g6cA:
undetectable
3douA-4g6cA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.86A 3jvyB-4g6cA:
undetectable
3jvyB-4g6cA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.94A 3nduC-4g6cA:
undetectable
3nduC-4g6cA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 11 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.89A 3nu3B-4g6cA:
undetectable
3nu3B-4g6cA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 10 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.85A 3nu6B-4g6cA:
undetectable
3nu6B-4g6cA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 9 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.86A 3nujB-4g6cA:
undetectable
3nujB-4g6cA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 9 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.86A 3nuoB-4g6cA:
undetectable
3nuoB-4g6cA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_2
(PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.90A 3pwmB-4g6cA:
undetectable
3pwmB-4g6cA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB9_A_EVPA605_1
(SERUM ALBUMIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 10 TYR A 108
ARG A 115
ALA A 314
HIS A 158
GLY A 159
None
1.21A 4lb9A-4g6cA:
0.2
4lb9A-4g6cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 LEU A  35
ALA A  63
ARG A  54
LEU A  10
CYH A 284
None
1.09A 4ltwA-4g6cA:
undetectable
4ltwA-4g6cA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 11 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.91A 4njvB-4g6cA:
undetectable
4njvB-4g6cA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
4 / 4 ALA A 269
ALA A 272
ALA A 273
ALA A 276
None
0.13A 4oaeA-4g6cA:
undetectable
4oaeA-4g6cA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 9 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.83A 4rvjB-4g6cA:
undetectable
4rvjB-4g6cA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 9 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.82A 4rvjD-4g6cA:
undetectable
4rvjD-4g6cA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 9 SER A 256
ALA A 269
VAL A   8
SER A 252
VAL A 281
None
1.29A 4z69A-4g6cA:
undetectable
4z69A-4g6cA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 10 GLY A 208
SER A 210
LEU A 211
LEU A 127
TYR A 204
None
1.25A 5hwkA-4g6cA:
undetectable
5hwkA-4g6cA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 10 GLY A 208
SER A 210
LEU A 211
LEU A 127
TYR A 204
None
1.25A 5hwkB-4g6cA:
undetectable
5hwkB-4g6cA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
4 / 6 VAL A 293
ALA A 289
GLN A 286
VAL A 283
None
1.01A 5i8fA-4g6cA:
undetectable
5i8fA-4g6cA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 GLY A 107
SER A 155
LEU A 156
VAL A 106
LEU A  88
None
1.30A 5ubbA-4g6cA:
undetectable
5ubbA-4g6cA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
4 / 8 ARG A 227
TRP A 235
ILE A 196
PRO A 173
None
1.03A 6a4iA-4g6cA:
undetectable
6a4iA-4g6cA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.88A 6dgxA-4g6cA:
undetectable
6dgxA-4g6cA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.87A 6dh3A-4g6cA:
undetectable
6dh3A-4g6cA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)
4g6c BETA-HEXOSAMINIDASE
1

(Burkholderia
cenocepacia)
5 / 12 ASP A 128
GLY A 174
VAL A 136
ILE A 215
ILE A 137
None
0.87A 6difB-4g6cA:
undetectable
6difB-4g6cA:
13.80