SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4g6j LIGHT CHAIN OF
ANTIBODY BINDING
FRAGMENT OF
CANAKINUMAB
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.72A 1ictD-4g6jL:
undetectable		 1ictD-4g6jL:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4g6j LIGHT CHAIN OF
ANTIBODY BINDING
FRAGMENT OF
CANAKINUMAB
(Homo
sapiens) 		6 / 12 LEU L  73
VAL L 104
ILE L 106
ALA L  80
VAL L  19
ILE L  21
 None
 1.45A 5j2tC-4g6jL:
undetectable		 5j2tC-4g6jL:
20.36