SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g6t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4g6t TYPE III CHAPERONE
PROTEIN SHCA
TYPE III EFFECTOR
HOPA1
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ALA B  41
MET A  19
LEU A  10
MET A 112
LEU A  17
 None
 1.29A 2oaxE-4g6tB:
undetectable		 2oaxE-4g6tB:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 4g6t TYPE III CHAPERONE
PROTEIN SHCA
TYPE III EFFECTOR
HOPA1
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A  40
ALA B  41
MET A  19
MET A 112
LEU A  17
 None
 1.33A 2oaxE-4g6tA:
undetectable		 2oaxE-4g6tA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 4g6t TYPE III CHAPERONE
PROTEIN SHCA
TYPE III EFFECTOR
HOPA1
(Pseudomonas
syringae
group
genomosp.
3;
Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ASP A  25
ASN B  83
SER B  66
 None
 0.99A 3lslA-4g6tA:
undetectable
3lslD-4g6tA:
undetectable		 3lslA-4g6tA:
18.22
3lslD-4g6tA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 4g6t TYPE III CHAPERONE
PROTEIN SHCA
TYPE III EFFECTOR
HOPA1
(Pseudomonas
syringae
group
genomosp.
3;
Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 SER B  66
ASP A  25
ASN B  83
 None
 0.95A 3lslA-4g6tB:
undetectable
3lslD-4g6tB:
undetectable		 3lslA-4g6tB:
20.98
3lslD-4g6tB:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_D_P06D801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4g6t TYPE III CHAPERONE
PROTEIN SHCA
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 ILE A  54
GLY A  55
CYH A  44
ASN A  31
 None
 0.85A 5hieD-4g6tA:
undetectable		 5hieD-4g6tA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIY_A_OAQA302_0
(SULFOTRANSFERASE)		 4g6t TYPE III CHAPERONE
PROTEIN SHCA
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 PRO A  21
VAL A  23
MET A  32
LEU A  40
THR A  41
 None
 1.22A 5tiyA-4g6tA:
undetectable		 5tiyA-4g6tA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4g6t TYPE III CHAPERONE
PROTEIN SHCA
TYPE III EFFECTOR
HOPA1
(Pseudomonas
syringae
group
genomosp.
3;
Pseudomonas
syringae
group
genomosp.
3) 		4 / 4 LEU A  91
LEU A  56
SER B  56
ALA B  58
 None
 1.01A 5uunA-4g6tA:
undetectable		 5uunA-4g6tA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 4g6t TYPE III EFFECTOR
HOPA1
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 SER B  56
LYS B  57
SER B  60
 None
 0.84A 6az3P-4g6tB:
undetectable		 6az3P-4g6tB:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 4g6t TYPE III CHAPERONE
PROTEIN SHCA
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 TYR A  95
PRO A  81
LEU A 115
 None
 0.95A 6beoA-4g6tA:
undetectable		 6beoA-4g6tA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 4g6t TYPE III CHAPERONE
PROTEIN SHCA
TYPE III EFFECTOR
HOPA1
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 LEU B  30
LEU A  42
THR A 107
ARG A  50
 None
 1.01A 6ew0G-4g6tB:
undetectable		 6ew0G-4g6tB:
25.30