SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g6u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 4g6u EC869 CDIA-CT
EC869 CDII
(Escherichia
coli) 		5 / 11 ILE B 112
THR A 252
THR B 120
GLY B 111
GLU A 250
 None
 0.99A 2fn1B-4g6uB:
undetectable		 2fn1B-4g6uB:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4g6u EC869 CDIA-CT
EC869 CDII
(Escherichia
coli;
Escherichia
coli) 		4 / 7 TYR B 142
SER A 254
SER A 253
THR A 252
 None
 1.00A 2i91A-4g6uB:
undetectable		 2i91A-4g6uB:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4g6u EC869 CDIA-CT
EC869 CDII
(Escherichia
coli;
Escherichia
coli) 		4 / 7 TYR B 142
SER A 254
SER A 253
THR A 252
 None
 1.00A 2i91B-4g6uB:
undetectable		 2i91B-4g6uB:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 4g6u EC869 CDII
(Escherichia
coli) 		4 / 5 LEU B 158
GLY B  52
ILE B 119
ILE B 121
 None
 0.83A 2q9rA-4g6uB:
undetectable		 2q9rA-4g6uB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4g6u EC869 CDII
(Escherichia
coli) 		5 / 12 ASN B  12
ILE B 121
THR B 120
VAL B 143
SER B 124
 None
 1.21A 3kpbA-4g6uB:
undetectable		 3kpbA-4g6uB:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4g6u EC869 CDII
(Escherichia
coli) 		4 / 8 ALA B  58
LEU B  51
ILE B 121
VAL B 110
 None
 0.83A 5nujA-4g6uB:
undetectable		 5nujA-4g6uB:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4g6u EC869 CDIA-CT
EC869 CDII
(Escherichia
coli;
Escherichia
coli) 		4 / 8 PRO A 185
ASP A 187
THR B  64
ASP A 201
 None
 1.14A 5t8sB-4g6uA:
undetectable		 5t8sB-4g6uA:
23.37