SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4g6v ADHESIN/HEMOLYSIN
(Burkholderia
pseudomallei) 		5 / 12 ILE A 269
LEU A 277
VAL A 243
ILE A 251
ILE A 292
 None
 0.99A 1oipA-4g6vA:
undetectable		 1oipA-4g6vA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 4g6v ADHESIN/HEMOLYSIN
CDII
(Burkholderia
pseudomallei;
Burkholderia
pseudomallei) 		5 / 12 PHE B  61
PHE B  45
ALA A 236
THR A 237
ILE B  50
 None
 1.30A 3ndiA-4g6vB:
undetectable		 3ndiA-4g6vB:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 4g6v ADHESIN/HEMOLYSIN
CDII
(Burkholderia
pseudomallei) 		4 / 5 PHE B   6
ILE B  91
ASN A 231
PHE B  62
 None
 1.23A 3octA-4g6vB:
undetectable		 3octA-4g6vB:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4g6v ADHESIN/HEMOLYSIN
(Burkholderia
pseudomallei) 		5 / 9 ASP A 284
ILE A 283
GLY A 287
THR A 193
GLN A 189
 None
 1.22A 4acaB-4g6vA:
undetectable
4acaC-4g6vA:
undetectable		 4acaB-4g6vA:
19.02
4acaC-4g6vA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 4g6v ADHESIN/HEMOLYSIN
(Burkholderia
pseudomallei) 		4 / 8 ASN A 188
PHE A 222
LEU A 194
ALA A 191
 None
 0.83A 5y7pC-4g6vA:
undetectable		 5y7pC-4g6vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4g6v ADHESIN/HEMOLYSIN
(Burkholderia
pseudomallei) 		4 / 8 ASN A 188
PHE A 222
LEU A 194
ALA A 191
 None
 0.83A 5y7pE-4g6vA:
undetectable		 5y7pE-4g6vA:
20.73