SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g6z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FFY_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 HIS A  18
GLY A  20
GLY A 206
ASP A 208
VAL A 236
 None
 0.79A 1ffyA-4g6zA:
13.2		 1ffyA-4g6zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 TYR A 304
VAL A 253
ILE A  17
ASN A  21
SER A  24
 None
 1.28A 1fm4A-4g6zA:
undetectable		 1fm4A-4g6zA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 11 HIS A  18
GLY A  20
GLY A 206
ASP A 208
VAL A 236
 None
 0.67A 1pg2A-4g6zA:
18.6		 1pg2A-4g6zA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 HIS A  18
GLY A  20
GLY A 206
ASP A 208
VAL A 236
 None
 0.79A 1qu2A-4g6zA:
13.2		 1qu2A-4g6zA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 4 ASP A 208
LEU A 233
GLY A 206
ARG A  23
 None
 1.36A 2j2pD-4g6zA:
undetectable
2j2pE-4g6zA:
undetectable		 2j2pD-4g6zA:
17.74
2j2pE-4g6zA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 5 GLU A  44
VAL A 193
CYH A 190
ARG A  42
 GLU  A 501 (-3.7A)
None
None
None
 1.10A 3amuA-4g6zA:
undetectable		 3amuA-4g6zA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		3 / 3 ILE A 204
ASP A 160
ARG A  23
 None
 0.84A 4pstA-4g6zA:
undetectable		 4pstA-4g6zA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_CZEA613_1
(SERUM ALBUMIN)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 9 ALA A 231
GLY A 206
LEU A 233
LEU A 297
LYS A 299
 None
 1.21A 5dqfA-4g6zA:
undetectable		 5dqfA-4g6zA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 6 LEU A 270
LEU A  26
PHE A   9
HIS A  18
 None
 0.99A 5gs4A-4g6zA:
undetectable		 5gs4A-4g6zA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 HIS A  18
GLY A  20
GLY A 206
ASP A 208
THR A 235
 None
 1.06A 5hg0A-4g6zA:
7.2		 5hg0A-4g6zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 HIS A  18
GLY A  20
GLY A 206
ASP A 208
THR A 235
 None
 1.06A 5hg0B-4g6zA:
5.4		 5hg0B-4g6zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 11 TYR A 187
ASN A 188
ASP A 194
VAL A 193
PRO A 185
 None
 1.17A 5hjiA-4g6zA:
undetectable		 5hjiA-4g6zA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		5 / 12 ALA A  25
LEU A  41
ILE A  43
TYR A 187
ASP A  57
 None
 1.46A 5vlmA-4g6zA:
undetectable		 5vlmA-4g6zA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 4g6z GLUTAMATE-TRNA
LIGASE
(Burkholderia
thailandensis) 		4 / 5 GLU A  44
VAL A 193
CYH A 190
ARG A  42
 GLU  A 501 (-3.7A)
None
None
None
 1.08A 6aggZ-4g6zA:
undetectable		 6aggZ-4g6zA:
10.70