SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.92A 1fm9A-4g7fA:
undetectable		 1fm9A-4g7fA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.88A 1k74A-4g7fA:
undetectable		 1k74A-4g7fA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 10 GLY A 387
LEU A 410
TYR A 129
THR A 390
GLY A 389
 None
None
EDO  A 502 ( 4.3A)
None
None
 1.16A 1kvlA-4g7fA:
undetectable		 1kvlA-4g7fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 6 SER A 113
ILE A 350
ALA A 353
THR A 323
ALA A  46
 None
 1.16A 1w0gA-4g7fA:
undetectable		 1w0gA-4g7fA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.92A 1xiuB-4g7fA:
undetectable		 1xiuB-4g7fA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.89A 1xlsA-4g7fA:
undetectable		 1xlsA-4g7fA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.88A 1xlsB-4g7fA:
undetectable		 1xlsB-4g7fA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.88A 1xlsC-4g7fA:
undetectable		 1xlsC-4g7fA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.88A 1xlsD-4g7fA:
undetectable		 1xlsD-4g7fA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 240
PHE A 148
GLY A 396
LEU A 341
VAL A 145
 None
 1.23A 2nyrB-4g7fA:
undetectable		 2nyrB-4g7fA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 340
LEU A 342
LEU A 384
ILE A 328
LEU A 135
 None
 1.07A 2pnjA-4g7fA:
undetectable		 2pnjA-4g7fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		4 / 7 SER A 357
CYH A 360
GLN A 346
ILE A 328
 None
 1.29A 2xz5A-4g7fA:
undetectable
2xz5B-4g7fA:
undetectable		 2xz5A-4g7fA:
19.06
2xz5B-4g7fA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 11 LEU A 110
TYR A 380
ILE A 350
ALA A 353
LEU A 342
 None
 1.12A 3n8yA-4g7fA:
undetectable		 3n8yA-4g7fA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		4 / 7 ILE A 350
LEU A 132
ALA A 120
ALA A 121
 None
 0.75A 3r9tB-4g7fA:
undetectable		 3r9tB-4g7fA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 340
LEU A 341
ILE A 381
ILE A 393
LEU A 388
 None
 1.29A 4j24C-4g7fA:
undetectable		 4j24C-4g7fA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 LEU A 340
LEU A 341
ILE A 381
ILE A 393
LEU A 388
 None
 1.23A 4j26B-4g7fA:
undetectable		 4j26B-4g7fA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		4 / 5 GLU A 208
ALA A 397
ASN A 152
GLU A 165
 None
None
None
MG  A 501 ( 4.7A)
 1.23A 5dwkC-4g7fA:
undetectable		 5dwkC-4g7fA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.98A 5z12B-4g7fA:
undetectable		 5z12B-4g7fA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		3 / 3 LYS A 118
LEU A 110
ASP A 378
 None
 0.84A 5zv2A-4g7fA:
undetectable		 5zv2A-4g7fA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		5 / 12 ILE A 116
ALA A 119
ALA A 120
LEU A  83
LEU A 135
 None
 0.90A 6a60D-4g7fA:
undetectable		 6a60D-4g7fA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 4g7f ENOLASE
(Trypanosoma
cruzi) 		4 / 6 SER A 113
ALA A 353
THR A 323
ALA A  46
 None
 1.11A 6ma6A-4g7fA:
undetectable		 6ma6A-4g7fA:
11.66