SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g8d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 7 PHE A  40
PHE A 251
PHE A  99
HIS A 248
 None
 1.01A 1lh6A-4g8dA:
undetectable		 1lh6A-4g8dA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		5 / 12 PHE A 138
ILE A 211
LEU A 235
ASN A 215
ILE A 123
 None
 1.32A 2e7fB-4g8dA:
undetectable		 2e7fB-4g8dA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		5 / 11 GLY A  61
ASN A  33
THR A 180
GLY A 182
PHE A 189
 None
 1.45A 2hmaA-4g8dA:
undetectable		 2hmaA-4g8dA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		5 / 12 ILE A  93
GLU A  19
VAL A  17
LEU A   8
ARG A  53
 None
 1.42A 2jj8C-4g8dA:
undetectable		 2jj8C-4g8dA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		5 / 12 THR A 126
ILE A 107
ALA A  81
THR A  85
LEU A  28
 None
 1.20A 3a50A-4g8dA:
undetectable		 3a50A-4g8dA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		5 / 8 GLY A 125
GLY A 102
GLY A 105
HIS A 106
ILE A 109
 None
 1.03A 3d41A-4g8dA:
undetectable		 3d41A-4g8dA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 6 PRO A  57
HIS A  31
LEU A  59
ALA A  83
 None
 1.31A 3gv1A-4g8dA:
1.5
3gv1C-4g8dA:
undetectable		 3gv1A-4g8dA:
22.58
3gv1C-4g8dA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 6 LEU A  59
ALA A  83
PRO A  57
HIS A  31
 None
 1.29A 3gv1A-4g8dA:
1.5
3gv1B-4g8dA:
undetectable		 3gv1A-4g8dA:
22.58
3gv1B-4g8dA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 8 ALA A 260
ALA A 263
LEU A  27
MET A 122
 None
 1.07A 3l4dD-4g8dA:
undetectable		 3l4dD-4g8dA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		5 / 12 LEU A 103
GLY A  79
ALA A  81
ILE A  15
ILE A 107
 None
 1.04A 3mwsA-4g8dA:
undetectable		 3mwsA-4g8dA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		5 / 12 PHE A 221
SER A 163
PHE A 152
VAL A 177
ALA A 147
 None
 1.43A 3nuvA-4g8dA:
undetectable		 3nuvA-4g8dA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 7 PRO A 128
ILE A 211
LEU A 209
ILE A 203
 None
 0.93A 3p50A-4g8dA:
undetectable		 3p50A-4g8dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 7 PRO A 128
ILE A 211
LEU A 209
ILE A 203
 None
 0.93A 3p50B-4g8dA:
undetectable		 3p50B-4g8dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 7 PRO A 128
ILE A 211
LEU A 209
ILE A 203
 None
 0.92A 3p50C-4g8dA:
undetectable		 3p50C-4g8dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 7 PRO A 128
ILE A 211
LEU A 209
ILE A 203
 None
 0.94A 3p50D-4g8dA:
undetectable		 3p50D-4g8dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 7 PRO A 128
ILE A 211
LEU A 209
ILE A 203
 None
 0.93A 3p50E-4g8dA:
undetectable		 3p50E-4g8dA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		5 / 12 ILE A 176
GLY A  32
ILE A  39
ILE A 107
ARG A 185
 None
 1.28A 3uj7A-4g8dA:
undetectable		 3uj7A-4g8dA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 7 ILE A 203
GLN A 200
PRO A 128
ILE A 123
 None
 0.86A 4w5oA-4g8dA:
2.2		 4w5oA-4g8dA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		3 / 3 ILE A  30
ILE A 109
MET A  84
 None
 0.65A 5i9yA-4g8dA:
undetectable		 5i9yA-4g8dA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		5 / 12 ILE A  30
GLY A 104
ARG A 114
ALA A  83
ILE A 112
 None
 1.26A 5igvA-4g8dA:
undetectable		 5igvA-4g8dA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		3 / 3 VAL A 204
GLU A 132
GLU A 133
 None
 0.90A 5jsdB-4g8dA:
undetectable
5jsdC-4g8dA:
undetectable		 5jsdB-4g8dA:
16.57
5jsdC-4g8dA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN
(Ochrobactrum
sp.
T63) 		4 / 7 THR A  85
ARG A 119
HIS A 274
ASP A  95
 None
 1.17A 6mn4E-4g8dA:
undetectable		 6mn4E-4g8dA:
25.39