SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g8k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		5 / 10 LEU A 278
LEU A 279
ALA A 280
LEU A 292
LEU A 320
 None
 1.30A 1gwrA-4g8kA:
undetectable		 1gwrA-4g8kA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		4 / 8 ALA A 128
PHE A 129
ALA A 133
LEU A 187
 None
 0.93A 2bxmA-4g8kA:
undetectable		 2bxmA-4g8kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		5 / 10 ALA A 128
PHE A 129
ALA A 133
LEU A 187
LEU A 108
 None
 1.02A 2bxqA-4g8kA:
undetectable		 2bxqA-4g8kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		5 / 7 ALA A 169
GLY A 168
GLY A 167
ASN A 200
PHE A 126
 None
 1.08A 2c49B-4g8kA:
undetectable		 2c49B-4g8kA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		5 / 12 LEU A 226
ALA A 246
VAL A 218
THR A 222
LEU A 206
 None
 1.03A 4dc3A-4g8kA:
undetectable		 4dc3A-4g8kA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		3 / 3 ILE A  30
MET A  69
ARG A  71
 None
 0.94A 4lnwA-4g8kA:
undetectable		 4lnwA-4g8kA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		4 / 6 PHE A  96
SER A 104
ALA A  99
LEU A 110
 None
 1.19A 5dzkB-4g8kA:
undetectable
5dzkP-4g8kA:
undetectable		 5dzkB-4g8kA:
22.82
5dzkP-4g8kA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		5 / 12 VAL A  33
ASP A  37
GLU A  36
LEU A  63
ALA A  66
 None
 0.98A 5nd7B-4g8kA:
undetectable		 5nd7B-4g8kA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		5 / 10 LEU A 279
LEU A 304
ASP A 303
LYS A 326
GLY A 273
 None
 1.08A 6dm0B-4g8kA:
undetectable
6dm0C-4g8kA:
undetectable		 6dm0B-4g8kA:
11.42
6dm0C-4g8kA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4g8k 2-5A-DEPENDENT
RIBONUCLEASE
(Homo
sapiens) 		5 / 9 GLY A 273
LEU A 279
LEU A 304
ASP A 303
LYS A 326
 None
 1.09A 6dm0A-4g8kA:
undetectable
6dm0D-4g8kA:
undetectable		 6dm0A-4g8kA:
11.42
6dm0D-4g8kA:
11.42