SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		5 / 12 VAL A 242
GLU A 262
GLY A 260
ASN A 233
GLN A 293
 None
None
None
NA  A 502 (-3.7A)
None
 1.14A 1vidA-4g8tA:
undetectable		 1vidA-4g8tA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 4 ARG A  58
GLY A  54
GLU A  55
SER A 343
 None
 1.21A 2xctS-4g8tA:
undetectable
2xctU-4g8tA:
undetectable		 2xctS-4g8tA:
21.57
2xctU-4g8tA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 8 TYR A 160
HIS A  28
GLY A 151
ILE A 150
 None
SO4  A 501 (-4.2A)
None
None
 0.84A 2zm9A-4g8tA:
undetectable		 2zm9A-4g8tA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		5 / 12 ILE A 358
ILE A 305
ASP A 304
GLY A 333
ASP A 357
 None
None
GOL  A 503 (-3.1A)
None
None
 1.02A 3bwcB-4g8tA:
undetectable		 3bwcB-4g8tA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN0_A_DMOA551_1
(ARGINASE-1)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		5 / 9 HIS A 335
ASP A 362
HIS A 364
ASP A 231
GLU A 256
 None
None
SO4  A 501 (-3.9A)
NA  A 502 (-2.3A)
NA  A 502 (-3.8A)
 1.49A 3gn0A-4g8tA:
undetectable		 3gn0A-4g8tA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		5 / 11 LEU A 344
VAL A 386
PHE A 197
PHE A 200
THR A 363
 None
 1.43A 3n23C-4g8tA:
undetectable		 3n23C-4g8tA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		3 / 3 HIS A 335
SER A 343
ASN A 338
 None
None
SO4  A 501 ( 4.9A)
 0.90A 3s8pB-4g8tA:
undetectable		 3s8pB-4g8tA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 8 ASN A 285
HIS A 364
ASP A 362
GLU A 212
 NA  A 502 (-3.3A)
SO4  A 501 (-3.9A)
None
None
 1.05A 3sg9B-4g8tA:
undetectable		 3sg9B-4g8tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		3 / 3 TYR A 171
MET A 143
LEU A 344
 None
 0.93A 3vw1D-4g8tA:
undetectable		 3vw1D-4g8tA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		5 / 12 PHE A 347
PHE A  32
LEU A 374
SER A 336
LEU A 409
 None
 1.06A 4dm8B-4g8tA:
undetectable		 4dm8B-4g8tA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 8 HIS A 311
PRO A 310
ASP A 309
SER A 334
 None
 1.02A 4k0bB-4g8tA:
undetectable		 4k0bB-4g8tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 8 HIS A 311
PRO A 310
ASP A 309
SER A 334
 None
 0.98A 4l7iB-4g8tA:
undetectable		 4l7iB-4g8tA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 5 ASN A 285
LEU A 307
SER A 336
LEU A 144
 NA  A 502 (-3.3A)
None
None
None
 1.26A 4n09C-4g8tA:
undetectable		 4n09C-4g8tA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 5 ILE A 244
LEU A 248
GLU A 212
VAL A 184
 None
 1.05A 4nkxB-4g8tA:
undetectable		 4nkxB-4g8tA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 6 LEU A 202
LEU A 187
VAL A 184
PHE A 148
 None
None
None
SO4  A 501 (-4.8A)
 1.14A 4uswA-4g8tA:
undetectable		 4uswA-4g8tA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 6 ASP A  91
LYS A  56
THR A 105
THR A  60
 None
 1.40A 4w5tA-4g8tA:
undetectable		 4w5tA-4g8tA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 5 ARG A  58
GLY A  54
GLU A  55
SER A 343
 None
 1.13A 4z3oA-4g8tA:
undetectable
4z3oB-4g8tA:
undetectable		 4z3oA-4g8tA:
21.02
4z3oB-4g8tA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA602_1
(SERUM ALBUMIN)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 8 ASN A 407
ALA A 406
VAL A 403
GLU A  50
 None
 0.89A 4zbqA-4g8tA:
undetectable		 4zbqA-4g8tA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 5 SER A 343
ARG A  58
GLY A  54
GLU A  55
 None
 0.78A 5cdqA-4g8tA:
undetectable
5cdqB-4g8tA:
undetectable
5cdqC-4g8tA:
undetectable		 5cdqA-4g8tA:
21.11
5cdqB-4g8tA:
20.67
5cdqC-4g8tA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 5 SER A 343
ARG A  58
GLY A  54
GLU A  55
 None
 0.78A 5cdqR-4g8tA:
undetectable
5cdqS-4g8tA:
undetectable
5cdqT-4g8tA:
undetectable		 5cdqR-4g8tA:
21.11
5cdqS-4g8tA:
20.67
5cdqT-4g8tA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		5 / 12 VAL A 242
GLU A 262
GLY A 260
ASN A 233
GLN A 293
 None
None
None
NA  A 502 (-3.7A)
None
 1.15A 5fhrA-4g8tA:
undetectable		 5fhrA-4g8tA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		3 / 3 TRP A 236
GLU A 212
ASP A 231
 None
None
NA  A 502 (-2.3A)
 0.55A 5gqbA-4g8tA:
3.2		 5gqbA-4g8tA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 7 ARG A  95
THR A 289
ASP A 290
GLY A  94
 None
 1.04A 5hwaA-4g8tA:
undetectable		 5hwaA-4g8tA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 8 ASP A  18
TYR A 160
PHE A 148
SER A  25
 None
None
SO4  A 501 (-4.8A)
None
 1.13A 5l1fA-4g8tA:
undetectable
5l1fB-4g8tA:
undetectable		 5l1fA-4g8tA:
20.61
5l1fB-4g8tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 7 HIS A  28
ASP A 231
GLY A 204
ASN A  23
 SO4  A 501 (-4.2A)
NA  A 502 (-2.3A)
None
SO4  A 501 (-3.3A)
 1.12A 5x7pA-4g8tA:
undetectable		 5x7pA-4g8tA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4g8t GLUCARATE
DEHYDRATASE
(Actinobacillus
succinogenes) 		4 / 5 HIS A  28
ASP A 231
GLY A 204
ASN A  23
 SO4  A 501 (-4.2A)
NA  A 502 (-2.3A)
None
SO4  A 501 (-3.3A)
 1.10A 5x7pB-4g8tA:
undetectable		 5x7pB-4g8tA:
17.34