SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4g8x RNA POLYMERASE SIGMA
FACTOR RPOD
(Staphylococcus
aureus) 		5 / 10 LEU A 317
LEU A 329
VAL A 332
ILE A 346
THR A 326
 None
 1.04A 2w9hA-4g8xA:
undetectable		 2w9hA-4g8xA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4g8x RNA POLYMERASE SIGMA
FACTOR RPOD
(Staphylococcus
aureus) 		4 / 7 THR A 326
LEU A 351
LYS A 349
LEU A 304
 None
 0.98A 4ib4A-4g8xA:
undetectable		 4ib4A-4g8xA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 4g8x RNA POLYMERASE SIGMA
FACTOR RPOD
(Staphylococcus
aureus) 		4 / 6 GLU A 311
GLU A 347
ALA A 350
LYS A 349
 None
 0.86A 6an0A-4g8xA:
undetectable		 6an0A-4g8xA:
8.50