SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g92'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 4g92 TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 11 LEU B  48
HIS C  85
LEU C  89
ALA C 114
PHE C 113
 None
 1.34A 1cmaA-4g92B:
undetectable
1cmaB-4g92B:
undetectable		 1cmaA-4g92B:
18.42
1cmaB-4g92B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4g92 TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 10 ALA C 114
PHE C 113
LEU B  48
HIS C  85
LEU C  89
 None
 1.24A 1cmcA-4g92C:
undetectable
1cmcB-4g92C:
undetectable		 1cmcA-4g92C:
19.05
1cmcB-4g92C:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4g92 TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 10 LEU B  48
HIS C  85
LEU C  89
ALA C 114
PHE C 113
 None
 1.23A 1cmcA-4g92B:
undetectable
1cmcB-4g92B:
undetectable		 1cmcA-4g92B:
18.42
1cmcB-4g92B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 4g92 TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 12 ALA C 114
PHE C 113
LEU B  48
HIS C  85
LEU C  89
 None
 1.30A 1mj2A-4g92C:
undetectable
1mj2B-4g92C:
undetectable		 1mj2A-4g92C:
19.05
1mj2B-4g92C:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 4g92 TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 12 ALA C 114
PHE C 113
LEU B  48
HIS C  85
LEU C  89
 None
 1.30A 1mjoC-4g92C:
undetectable
1mjoD-4g92C:
undetectable		 1mjoC-4g92C:
19.05
1mjoD-4g92C:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4g92 TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 11 LEU B  48
HIS C  85
LEU C  89
ALA C 114
PHE C 113
 None
 1.26A 1mjqA-4g92B:
undetectable
1mjqB-4g92B:
undetectable		 1mjqA-4g92B:
18.42
1mjqB-4g92B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4g92 TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 10 LEU B  48
HIS C  85
LEU C  89
ALA C 114
PHE C 113
 None
 1.28A 1mjqC-4g92B:
undetectable
1mjqD-4g92B:
undetectable		 1mjqC-4g92B:
18.42
1mjqD-4g92B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4g92 TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 11 LEU B  48
HIS C  85
LEU C  89
ALA C 114
PHE C 113
 None
 1.27A 1mjqI-4g92B:
undetectable
1mjqJ-4g92B:
undetectable		 1mjqI-4g92B:
18.42
1mjqJ-4g92B:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4g92 TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans) 		3 / 3 PRO C  88
ASN B  52
ARG B  55
 None
 0.97A 2qeuB-4g92C:
undetectable		 2qeuB-4g92C:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4g92 HAPB PROTEIN
TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans;
Aspergillus
nidulans) 		4 / 8 TYR A 235
ASP C 153
GLN C  54
GLU B 117
 None
 1.39A 3dh0A-4g92A:
undetectable		 3dh0A-4g92A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 4g92 HAPE
TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
(Aspergillus
nidulans) 		5 / 12 TYR B 119
PHE C 157
PHE C 120
VAL C 119
GLY C 116
 None
 1.31A 4mm6A-4g92B:
undetectable		 4mm6A-4g92B:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4g92 HAPE
TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
(Aspergillus
nidulans) 		5 / 7 LEU B 127
TYR B 130
GLY B 104
ALA C 109
SER C 106
 None
 1.48A 5f1aB-4g92B:
undetectable		 5f1aB-4g92B:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4g92 TRANSCRIPTION FACTOR
HAPC (EUROFUNG)
HAPE
(Aspergillus
nidulans;
Aspergillus
nidulans) 		5 / 11 GLY B 104
ASP B 106
ALA C 109
PRO C 110
ILE C 105
 None
 1.19A 5yk2A-4g92B:
undetectable		 5yk2A-4g92B:
12.67