SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 8 HIS A 486
GLY A 521
GLY A 514
ASP A 459
 ZN  A1003 (-3.4A)
None
None
None
 0.80A 1aegA-4g9iA:
undetectable		 1aegA-4g9iA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 8 THR A 605
GLY A 602
GLY A 559
SER A 562
 None
 0.74A 1d0vA-4g9iA:
undetectable		 1d0vA-4g9iA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 8 THR A 605
GLY A 602
GLY A 559
SER A 562
 None
 0.75A 1jhaA-4g9iA:
2.1		 1jhaA-4g9iA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 11 HIS A 490
HIS A 486
SER A 550
GLY A 522
ILE A 491
 ZN  A1003 (-3.0A)
ZN  A1003 (-3.4A)
None
None
None
 1.11A 1jzsA-4g9iA:
undetectable		 1jzsA-4g9iA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_B_CCSB417_0
(ESTROGEN RECEPTOR)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 6 PRO A 268
GLU A 719
LYS A 377
VAL A 374
 None
 1.44A 1l2iB-4g9iA:
undetectable		 1l2iB-4g9iA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		3 / 3 CYH A 112
ARG A 172
CYH A 109
 ZN  A1001 (-2.6A)
None
ZN  A1001 (-2.7A)
 1.43A 1p9gA-4g9iA:
undetectable		 1p9gA-4g9iA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		3 / 3 CYH A 181
ARG A 123
CYH A 162
 ZN  A1002 (-2.8A)
None
ZN  A1002 (-2.6A)
 1.40A 1p9gA-4g9iA:
undetectable		 1p9gA-4g9iA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 11 GLY A 705
ALA A 701
PHE A 704
LEU A 535
VAL A 709
 None
 1.00A 1ukbA-4g9iA:
undetectable		 1ukbA-4g9iA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		3 / 3 GLN A 247
HIS A 629
ARG A 628
 None
 0.88A 1zlqA-4g9iA:
undetectable		 1zlqA-4g9iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 6 ARG A 245
THR A 328
ASP A 368
ASP A 105
 None
 1.23A 2okcA-4g9iA:
undetectable		 2okcA-4g9iA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 6 ARG A 245
THR A 328
ASP A 368
ASP A 105
 None
 1.22A 2okcB-4g9iA:
undetectable		 2okcB-4g9iA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		6 / 12 GLY A 612
ASP A 746
GLY A 745
GLY A 713
GLY A 510
HIS A 737
 None
ZN  A1003 (-2.4A)
None
ZN  A1003 ( 4.8A)
None
None
 1.28A 2oxtD-4g9iA:
undetectable		 2oxtD-4g9iA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 12 GLY A 514
SER A 493
ASP A 509
ASP A 746
ASP A 459
 None
None
ZN  A1003 (-2.2A)
ZN  A1003 (-2.4A)
None
 1.24A 2vqyA-4g9iA:
undetectable		 2vqyA-4g9iA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 8 GLY A 304
ILE A 381
ALA A 297
HIS A 301
 None
 0.89A 2x0pA-4g9iA:
1.4		 2x0pA-4g9iA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		3 / 3 TYR A 174
GLU A  89
ASN A  36
 None
 0.91A 2y7hC-4g9iA:
undetectable		 2y7hC-4g9iA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 9 GLY A 223
GLY A 220
LEU A 348
LEU A 226
ALA A 330
 None
 0.98A 2z0yA-4g9iA:
undetectable		 2z0yA-4g9iA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 9 GLY A 223
GLY A 220
LEU A 348
LEU A 226
ALA A 330
 None
 0.82A 2z0yB-4g9iA:
undetectable		 2z0yB-4g9iA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 7 TYR A 309
ILE A 362
ILE A 221
HIS A 358
 None
 1.01A 2zm7A-4g9iA:
undetectable		 2zm7A-4g9iA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 12 VAL A 749
VAL A 403
GLY A 404
THR A 428
ILE A 425
 None
 1.03A 3bf1A-4g9iA:
11.2
3bf1B-4g9iA:
11.5		 3bf1A-4g9iA:
15.86
3bf1B-4g9iA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 11 LEU A 638
ASN A 718
VAL A 715
GLY A 612
ILE A 618
 None
 1.18A 3bf1C-4g9iA:
11.4
3bf1D-4g9iA:
11.5		 3bf1C-4g9iA:
15.86
3bf1D-4g9iA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 7 ILE A 392
PHE A 444
PHE A 411
GLY A 752
 None
 1.00A 3em0B-4g9iA:
undetectable		 3em0B-4g9iA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 12 HIS A 486
GLY A 512
ASP A 459
VAL A 738
GLY A 714
 ZN  A1003 (-3.4A)
None
None
None
ZN  A1003 ( 4.6A)
 1.00A 3keeC-4g9iA:
undetectable		 3keeC-4g9iA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 12 ARG A 245
HIS A 313
THR A 312
ALA A 227
LEU A 356
 None
 1.34A 3lcvB-4g9iA:
undetectable		 3lcvB-4g9iA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 7 VAL A 388
VAL A 413
ILE A 447
ARG A 365
 None
 1.03A 3ms9B-4g9iA:
undetectable		 3ms9B-4g9iA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 8 ASP A 746
ASP A 509
GLY A 512
ARG A 613
 ZN  A1003 (-2.4A)
ZN  A1003 (-2.2A)
None
None
 1.03A 3s3nA-4g9iA:
3.5		 3s3nA-4g9iA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 12 THR A 243
GLY A 334
ARG A 242
ASP A 350
GLU A 238
 None
 1.16A 3tkaA-4g9iA:
undetectable		 3tkaA-4g9iA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		3 / 3 ASP A 340
ARG A 365
LYS A 339
 None
 1.13A 3wipG-4g9iA:
undetectable		 3wipG-4g9iA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 7 ARG A 445
LEU A 448
GLY A 412
SER A 422
 None
 0.95A 4cp3A-4g9iA:
undetectable
4cp3B-4g9iA:
undetectable		 4cp3A-4g9iA:
10.08
4cp3B-4g9iA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 4 LEU A 292
PRO A 293
LEU A 296
ILE A 252
 None
 0.93A 4f4dB-4g9iA:
undetectable		 4f4dB-4g9iA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 6 THR A 466
GLY A 404
ASN A 409
GLY A 512
 None
 0.88A 4fjpA-4g9iA:
undetectable		 4fjpA-4g9iA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_2_PQN22002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 9 SER A 493
ARG A 744
ALA A 716
LEU A 711
ALA A 710
 None
 1.47A 4l6v2-4g9iA:
0.0		 4l6v2-4g9iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		3 / 3 ASP A 509
ASP A 746
ASN A 427
 ZN  A1003 (-2.2A)
ZN  A1003 (-2.4A)
None
 0.74A 4q5mA-4g9iA:
undetectable		 4q5mA-4g9iA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 5 GLY A 522
HIS A 487
GLY A 510
GLU A 523
 None
 1.01A 4v20A-4g9iA:
undetectable		 4v20A-4g9iA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y28_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 9 SER A 493
ARG A 744
ALA A 716
LEU A 711
ALA A 710
 None
 1.50A 4y28B-4g9iA:
undetectable		 4y28B-4g9iA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 4 VAL A 524
ALA A 507
PHE A 693
THR A 611
 None
 1.25A 4z4fA-4g9iA:
2.3		 4z4fA-4g9iA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 4 VAL A 524
ALA A 507
PHE A 693
THR A 611
 None
 1.24A 4z4hA-4g9iA:
2.4		 4z4hA-4g9iA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		3 / 3 ASP A 459
ASN A 750
PHE A 755
 None
 0.76A 5dsgB-4g9iA:
undetectable		 5dsgB-4g9iA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 6 ARG A 628
ASP A 509
GLY A 714
ASP A 746
 None
ZN  A1003 (-2.2A)
ZN  A1003 ( 4.6A)
ZN  A1003 (-2.4A)
 1.11A 5hp1C-4g9iA:
2.3		 5hp1C-4g9iA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_I_IPHI101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 6 VAL A 573
LEU A 570
CYH A 577
LEU A 557
 None
 1.04A 5hrqB-4g9iA:
undetectable
5hrqI-4g9iA:
undetectable
5hrqJ-4g9iA:
undetectable		 5hrqB-4g9iA:
3.41
5hrqI-4g9iA:
2.35
5hrqJ-4g9iA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 12 ILE A 538
GLY A 521
GLU A 652
PHE A 666
ALA A 617
 None
 1.21A 5igyA-4g9iA:
undetectable		 5igyA-4g9iA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 12 ALA A 710
PHE A 666
ILE A 560
TYR A 541
THR A 722
 None
 1.23A 5jlcA-4g9iA:
undetectable		 5jlcA-4g9iA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 5 TYR A 626
VAL A 620
ASP A 616
ALA A 619
 None
 1.04A 5otrA-4g9iA:
undetectable		 5otrA-4g9iA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_B_PQNB1844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 10 SER A 493
ARG A 744
ALA A 716
LEU A 711
ALA A 710
 None
 1.42A 5oy0b-4g9iA:
undetectable		 5oy0b-4g9iA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 6 VAL A 524
ALA A 507
PHE A 693
THR A 611
 None
 1.18A 5t7bA-4g9iA:
undetectable		 5t7bA-4g9iA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		4 / 5 THR A 766
THR A 515
HIS A 487
LEU A 525
 None
 1.33A 5utuH-4g9iA:
undetectable		 5utuH-4g9iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 12 GLY A 521
VAL A 532
GLY A 505
PHE A 693
ILE A 491
 None
 1.03A 5vooA-4g9iA:
2.1		 5vooA-4g9iA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 12 GLY A 521
VAL A 532
GLY A 505
PHE A 693
ILE A 491
 None
 1.05A 5vooB-4g9iA:
undetectable		 5vooB-4g9iA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 12 GLY A 521
VAL A 532
GLY A 505
PHE A 693
ILE A 491
 None
 1.05A 5vooC-4g9iA:
2.0		 5vooC-4g9iA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		5 / 9 VAL A 484
GLY A 748
VAL A 751
ASP A 746
GLY A 745
 None
None
None
ZN  A1003 (-2.4A)
None
 1.13A 5zniA-4g9iA:
undetectable		 5zniA-4g9iA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		3 / 3 GLU A 271
LEU A 274
ARG A 279
 None
 0.77A 6d8fA-4g9iA:
2.1		 6d8fA-4g9iA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4g9i HYDROGENASE
MATURATION PROTEIN
HYPF
(Thermococcus
kodakarensis) 		3 / 3 THR A 466
GLU A 631
ASN A 409
 None
 0.91A 6nj9K-4g9iA:
undetectable		 6nj9K-4g9iA:
20.95