SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g9k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  68
ALA A  65
LEU A  69
ILE A  81
 PHE  A  68 ( 1.3A)
ALA  A  65 ( 0.0A)
LEU  A  69 ( 0.6A)
ILE  A  81 ( 0.4A)
 1.08A 1sbrA-4g9kA:
undetectable
1sbrB-4g9kA:
undetectable		 1sbrA-4g9kA:
17.93
1sbrB-4g9kA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BPX_B_MK1B902_2
(HIV-1 PROTEASE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  64
ALA A  65
ILE A 111
VAL A  56
ILE A  58
 GLY  A  64 (-0.0A)
ALA  A  65 ( 0.0A)
ILE  A 111 ( 0.7A)
VAL  A  56 ( 0.6A)
ILE  A  58 ( 0.7A)
 0.80A 2bpxB-4g9kA:
undetectable		 2bpxB-4g9kA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  64
ALA A  65
ILE A  81
ILE A 111
ILE A  58
 GLY  A  64 (-0.0A)
ALA  A  65 ( 0.0A)
ILE  A  81 ( 0.4A)
ILE  A 111 ( 0.7A)
ILE  A  58 ( 0.7A)
 0.80A 2hs1A-4g9kA:
undetectable		 2hs1A-4g9kA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  64
ALA A  65
ILE A  81
ILE A 111
ILE A  58
 GLY  A  64 (-0.0A)
ALA  A  65 ( 0.0A)
ILE  A  81 ( 0.4A)
ILE  A 111 ( 0.7A)
ILE  A  58 ( 0.7A)
 0.78A 2hs1B-4g9kA:
undetectable		 2hs1B-4g9kA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  93
SER A 106
ASP A 498
ASP A 103
 LEU  A  93 ( 0.6A)
SER  A 106 ( 0.0A)
ASP  A 498 ( 0.6A)
ASP  A 103 ( 0.6A)
 1.15A 2j2pE-4g9kA:
undetectable
2j2pF-4g9kA:
undetectable		 2j2pE-4g9kA:
17.78
2j2pF-4g9kA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 285
THR A 458
ALA A 457
LEU A 450
THR A 474
 LEU  A 285 ( 0.6A)
THR  A 458 ( 0.8A)
ALA  A 457 ( 0.0A)
LEU  A 450 ( 0.6A)
THR  A 474 ( 0.8A)
 1.22A 2npnA-4g9kA:
undetectable		 2npnA-4g9kA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 396
HIS A 397
GLY A 382
ILE A 381
 ALA  A 396 (-0.0A)
HIS  A 397 ( 1.0A)
GLY  A 382 (-0.0A)
ILE  A 381 ( 0.7A)
 0.79A 2zm9A-4g9kA:
undetectable		 2zm9A-4g9kA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 293
ALA A 244
LEU A 278
HIS A 269
GLN A 267
 LEU  A 293 ( 0.5A)
ALA  A 244 ( 0.0A)
LEU  A 278 ( 0.5A)
HIS  A 269 ( 1.0A)
GLN  A 267 ( 0.6A)
 1.30A 3bszE-4g9kA:
undetectable		 3bszE-4g9kA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  69
SER A  67
PHE A  68
ILE A  58
 LEU  A  69 ( 0.6A)
SER  A  67 ( 0.0A)
PHE  A  68 ( 1.3A)
ILE  A  58 ( 0.7A)
 0.98A 3ko0B-4g9kA:
undetectable		 3ko0B-4g9kA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  69
SER A  67
PHE A  68
ILE A  58
 LEU  A  69 ( 0.6A)
SER  A  67 ( 0.0A)
PHE  A  68 ( 1.3A)
ILE  A  58 ( 0.7A)
 1.01A 3ko0S-4g9kA:
undetectable		 3ko0S-4g9kA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 195
SER A 201
LEU A  94
PRO A  95
 LEU  A 195 (-0.6A)
SER  A 201 ( 0.0A)
LEU  A  94 ( 0.6A)
PRO  A  95 ( 1.1A)
 1.23A 3onnA-4g9kA:
undetectable		 3onnA-4g9kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 467
GLY A 469
THR A 468
LEU A 477
 TYR  A 467 ( 1.3A)
GLY  A 469 ( 0.0A)
THR  A 468 ( 0.8A)
LEU  A 477 ( 0.6A)
 0.96A 3ps9A-4g9kA:
5.9		 3ps9A-4g9kA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 165
ILE A  46
LEU A 159
ALA A 127
 ALA  A 165 ( 0.0A)
ILE  A  46 ( 0.4A)
LEU  A 159 ( 0.6A)
ALA  A 127 ( 0.0A)
 0.85A 3r9sC-4g9kA:
undetectable		 3r9sC-4g9kA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 147
LEU A 157
LEU A 159
ILE A 167
 VAL  A 147 ( 0.6A)
LEU  A 157 ( 0.6A)
LEU  A 159 ( 0.6A)
ILE  A 167 ( 0.7A)
 0.84A 3u5kB-4g9kA:
undetectable		 3u5kB-4g9kA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 147
LEU A 157
LEU A 159
ILE A 167
 VAL  A 147 ( 0.6A)
LEU  A 157 ( 0.6A)
LEU  A 159 ( 0.6A)
ILE  A 167 ( 0.7A)
 0.82A 4a9jA-4g9kA:
undetectable		 4a9jA-4g9kA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 147
LEU A 157
LEU A 159
ILE A 167
 VAL  A 147 ( 0.6A)
LEU  A 157 ( 0.6A)
LEU  A 159 ( 0.6A)
ILE  A 167 ( 0.7A)
 0.81A 4a9jB-4g9kA:
undetectable		 4a9jB-4g9kA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 147
LEU A 157
LEU A 159
ILE A 167
 VAL  A 147 ( 0.6A)
LEU  A 157 ( 0.6A)
LEU  A 159 ( 0.6A)
ILE  A 167 ( 0.7A)
 0.94A 4a9jC-4g9kA:
undetectable		 4a9jC-4g9kA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  60
SER A  61
ILE A  82
ALA A 129
VAL A 139
 GLY  A  60 (-0.0A)
SER  A  61 (-0.0A)
ILE  A  82 (-0.7A)
ALA  A 129 (-0.0A)
VAL  A 139 ( 0.6A)
 0.86A 4dx5B-4g9kA:
undetectable		 4dx5B-4g9kA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 406
GLN A 371
PHE A 369
ASN A 434
 ASN  A 406 ( 0.6A)
GLN  A 371 ( 0.6A)
PHE  A 369 ( 1.3A)
ASN  A 434 ( 0.6A)
 1.36A 4kcnB-4g9kA:
undetectable		 4kcnB-4g9kA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  60
SER A  61
ILE A  82
ALA A 129
VAL A 139
 GLY  A  60 (-0.0A)
SER  A  61 (-0.0A)
ILE  A  82 (-0.7A)
ALA  A 129 (-0.0A)
VAL  A 139 ( 0.6A)
 0.87A 4u8vB-4g9kA:
undetectable		 4u8vB-4g9kA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  60
SER A  61
ILE A  82
ALA A 129
VAL A 139
 GLY  A  60 (-0.0A)
SER  A  61 (-0.0A)
ILE  A  82 (-0.7A)
ALA  A 129 (-0.0A)
VAL  A 139 ( 0.6A)
 0.90A 4u8yB-4g9kA:
undetectable		 4u8yB-4g9kA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  60
SER A  61
ILE A  82
ALA A 129
VAL A 139
 GLY  A  60 (-0.0A)
SER  A  61 (-0.0A)
ILE  A  82 (-0.7A)
ALA  A 129 (-0.0A)
VAL  A 139 ( 0.6A)
 0.84A 4u95B-4g9kA:
undetectable		 4u95B-4g9kA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 SER A  83
GLU A 128
PRO A 345
ILE A 347
SER A 174
 SER  A  83 (-0.0A)
GLU  A 128 (-0.5A)
PRO  A 345 ( 1.1A)
ILE  A 347 ( 0.7A)
SER  A 174 ( 0.0A)
 1.31A 4uroB-4g9kA:
undetectable		 4uroB-4g9kA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 6 SER A  83
GLU A 126
GLY A 382
ASP A 383
GLY A  64
 SER  A  83 (-0.0A)
GLU  A 126 ( 0.5A)
GLY  A 382 (-0.0A)
ASP  A 383 (-0.5A)
GLY  A  64 (-0.0A)
 1.05A 5cdnA-4g9kA:
undetectable
5cdnB-4g9kA:
2.2		 5cdnA-4g9kA:
22.75
5cdnB-4g9kA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 126
GLY A 382
ASP A 383
GLY A  64
 GLU  A 126 ( 0.5A)
GLY  A 382 (-0.0A)
ASP  A 383 (-0.5A)
GLY  A  64 (-0.0A)
 0.74A 5cdnC-4g9kA:
undetectable
5cdnD-4g9kA:
undetectable		 5cdnC-4g9kA:
22.75
5cdnD-4g9kA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 126
GLY A 382
ASP A 383
GLY A  64
 GLU  A 126 ( 0.5A)
GLY  A 382 (-0.0A)
ASP  A 383 (-0.5A)
GLY  A  64 (-0.0A)
 0.78A 5cdnT-4g9kA:
undetectable
5cdnU-4g9kA:
undetectable		 5cdnT-4g9kA:
22.75
5cdnU-4g9kA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 365
GLY A 374
SER A 375
GLY A 363
SER A 360
 ALA  A 365 ( 0.0A)
GLY  A 374 ( 0.0A)
SER  A 375 ( 0.0A)
GLY  A 363 ( 0.0A)
SER  A 360 ( 0.0A)
 1.11A 5gwxA-4g9kA:
3.1		 5gwxA-4g9kA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 298
VAL A 277
GLY A 470
THR A 474
PHE A 475
 ILE  A 298 ( 0.7A)
VAL  A 277 ( 0.6A)
GLY  A 470 ( 0.0A)
THR  A 474 ( 0.8A)
PHE  A 475 ( 1.3A)
 1.22A 5igiA-4g9kA:
undetectable		 5igiA-4g9kA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 385
ALA A 387
ALA A 175
GLY A 382
PRO A 390
 ALA  A 385 ( 0.0A)
ALA  A 387 ( 0.0A)
ALA  A 175 (-0.0A)
GLY  A 382 (-0.0A)
PRO  A 390 ( 1.1A)
 1.46A 5jglA-4g9kA:
3.9		 5jglA-4g9kA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 385
ALA A 387
ALA A 175
GLY A 382
PRO A 390
 ALA  A 385 ( 0.0A)
ALA  A 387 ( 0.0A)
ALA  A 175 (-0.0A)
GLY  A 382 (-0.0A)
PRO  A 390 ( 1.1A)
 1.45A 5jglB-4g9kA:
3.0		 5jglB-4g9kA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 185
VAL A 234
VAL A 306
TRP A 337
 ILE  A 185 ( 0.7A)
VAL  A 234 ( 0.6A)
VAL  A 306 ( 0.6A)
TRP  A 337 ( 0.5A)
 0.28A 5jwaH-4g9kA:
48.4		 5jwaH-4g9kA:
30.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 468
THR A 458
ALA A 446
GLY A 470
ALA A 455
 THR  A 468 ( 0.8A)
THR  A 458 ( 0.8A)
ALA  A 446 ( 0.0A)
GLY  A 470 ( 0.0A)
ALA  A 455 ( 0.0A)
 1.11A 5l5zK-4g9kA:
undetectable
5l5zL-4g9kA:
undetectable		 5l5zK-4g9kA:
17.83
5l5zL-4g9kA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 9 THR A 468
THR A 458
ALA A 446
GLY A 470
ALA A 455
 THR  A 468 ( 0.8A)
THR  A 458 ( 0.8A)
ALA  A 446 ( 0.0A)
GLY  A 470 ( 0.0A)
ALA  A 455 ( 0.0A)
 1.11A 5l5zY-4g9kA:
undetectable
5l5zZ-4g9kA:
undetectable		 5l5zY-4g9kA:
17.83
5l5zZ-4g9kA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 336
PHE A 208
VAL A 233
ASP A 249
ILE A 268
 ILE  A 336 ( 0.7A)
PHE  A 208 ( 1.3A)
VAL  A 233 ( 0.6A)
ASP  A 249 ( 0.6A)
ILE  A 268 ( 0.7A)
 1.25A 5lg3F-4g9kA:
undetectable		 5lg3F-4g9kA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 336
PHE A 208
VAL A 233
ASP A 249
ILE A 268
 ILE  A 336 ( 0.7A)
PHE  A 208 ( 1.3A)
VAL  A 233 ( 0.6A)
ASP  A 249 ( 0.6A)
ILE  A 268 ( 0.7A)
 1.24A 5lg3G-4g9kA:
undetectable		 5lg3G-4g9kA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 336
PHE A 208
VAL A 233
ASP A 249
ILE A 268
 ILE  A 336 ( 0.7A)
PHE  A 208 ( 1.3A)
VAL  A 233 ( 0.6A)
ASP  A 249 ( 0.6A)
ILE  A 268 ( 0.7A)
 1.25A 5lg3H-4g9kA:
undetectable		 5lg3H-4g9kA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 343
GLY A 382
TRP A  63
ALA A 400
ALA A 175
 ALA  A 343 ( 0.0A)
GLY  A 382 (-0.0A)
TRP  A  63 (-0.5A)
ALA  A 400 ( 0.0A)
ALA  A 175 (-0.0A)
 1.18A 5n5dA-4g9kA:
2.6		 5n5dA-4g9kA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 147
LEU A 157
LEU A 159
ILE A 167
 VAL  A 147 ( 0.6A)
LEU  A 157 ( 0.6A)
LEU  A 159 ( 0.6A)
ILE  A 167 ( 0.7A)
 0.84A 5y1yA-4g9kA:
undetectable		 5y1yA-4g9kA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 173
VAL A  56
ILE A  72
THR A  74
 ILE  A 173 ( 0.4A)
VAL  A  56 ( 0.6A)
ILE  A  72 ( 0.4A)
THR  A  74 ( 0.8A)
 0.92A 6cduF-4g9kA:
undetectable
6cduG-4g9kA:
undetectable		 6cduF-4g9kA:
20.88
6cduG-4g9kA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 406
GLY A  64
ALA A  65
VAL A  79
 ASN  A 406 ( 0.6A)
GLY  A  64 (-0.0A)
ALA  A  65 ( 0.0A)
VAL  A  79 ( 0.6A)
 0.85A 6dwnB-4g9kA:
undetectable		 6dwnB-4g9kA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE
(Saccharomyces
cerevisiae) 		5 / 10 SER A 286
MET A 280
GLY A 340
ALA A 178
ASN A 279
 SER  A 286 ( 0.0A)
MET  A 280 ( 0.0A)
GLY  A 340 ( 0.0A)
ALA  A 178 ( 0.0A)
ASN  A 279 ( 0.6A)
 1.35A 6hu9L-4g9kA:
undetectable
6hu9P-4g9kA:
undetectable
6hu9T-4g9kA:
undetectable		 6hu9L-4g9kA:
23.60
6hu9P-4g9kA:
16.74
6hu9T-4g9kA:
11.03