SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g9s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4g9s INHIBITOR OF G-TYPE
LYSOZYME
(Escherichia
coli) 		5 / 10 SER B  90
PHE B  54
LEU B 109
VAL B 111
VAL B  64
 None
 1.40A 1q23E-4g9sB:
undetectable		 1q23E-4g9sB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4g9s INHIBITOR OF G-TYPE
LYSOZYME
(Escherichia
coli) 		5 / 11 SER B  90
PHE B  54
LEU B 109
VAL B 111
VAL B  64
 None
 1.37A 1q23I-4g9sB:
undetectable		 1q23I-4g9sB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4g9s INHIBITOR OF G-TYPE
LYSOZYME
(Escherichia
coli) 		5 / 11 SER B  90
PHE B  54
LEU B 109
VAL B 111
VAL B  64
 None
 1.32A 1q23L-4g9sB:
undetectable		 1q23L-4g9sB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_D_ASDD1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4g9s INHIBITOR OF G-TYPE
LYSOZYME
(Escherichia
coli) 		5 / 9 LEU B  75
ALA B 103
LEU B 101
ALA B  56
PHE B  54
 None
 1.23A 2vcvD-4g9sB:
undetectable		 2vcvD-4g9sB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4g9s INHIBITOR OF G-TYPE
LYSOZYME
(Escherichia
coli) 		5 / 9 LEU B  75
ALA B 103
LEU B 101
ALA B  56
PHE B  54
 None
 1.23A 2vcvH-4g9sB:
undetectable		 2vcvH-4g9sB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_I_ASDI1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4g9s INHIBITOR OF G-TYPE
LYSOZYME
(Escherichia
coli) 		5 / 9 LEU B  75
ALA B 103
LEU B 101
ALA B  56
PHE B  54
 None
 1.25A 2vcvI-4g9sB:
undetectable		 2vcvI-4g9sB:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 4g9s INHIBITOR OF G-TYPE
LYSOZYME
(Escherichia
coli) 		3 / 3 SER B  37
ARG B  32
GLN B  39
 FLC  B 201 (-2.7A)
None
None
 0.83A 2xnrA-4g9sB:
undetectable		 2xnrA-4g9sB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 4g9s INHIBITOR OF G-TYPE
LYSOZYME
(Escherichia
coli) 		4 / 7 ASN B  68
GLY B  70
ALA B  71
ASP B  72
 None
 0.60A 5kqyB-4g9sB:
undetectable		 5kqyB-4g9sB:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4g9s INHIBITOR OF G-TYPE
LYSOZYME
(Escherichia
coli) 		4 / 8 ASN B  68
GLY B  70
ALA B  71
ASP B  72
 None
 0.56A 5kr1B-4g9sB:
undetectable		 5kr1B-4g9sB:
19.66