SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4g9z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 8 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.95A 1hwiB-4g9zA:
undetectable		 1hwiB-4g9zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 8 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.93A 1hwiD-4g9zA:
undetectable		 1hwiD-4g9zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 8 CYH A 409
LEU A 554
ALA A 376
LEU A 373
 None
 0.93A 1hwiC-4g9zA:
undetectable		 1hwiC-4g9zA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 5 MET A 388
ALA A 401
ILE A 400
ASP A 466
 None
None
None
G  F   6 ( 4.6A)
 1.20A 1upfA-4g9zA:
undetectable		 1upfA-4g9zA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 5 MET A 388
ALA A 401
ILE A 400
ASP A 466
 None
None
None
G  F   6 ( 4.6A)
 1.12A 1upfC-4g9zA:
undetectable		 1upfC-4g9zA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		5 / 12 ILE A 450
VAL A 449
LEU A 373
LEU A 453
VAL A 553
 None
 1.05A 4m11D-4g9zA:
undetectable		 4m11D-4g9zA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		3 / 3 ASP A 504
HIS A 507
LYS A 503
 None
 0.90A 4qzuD-4g9zA:
undetectable		 4qzuD-4g9zA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ILE A 484
GLN A 462
ILE A 467
ASP A 466
 None
G  F   6 ( 3.9A)
None
G  F   6 ( 4.6A)
 1.19A 4w5qA-4g9zA:
undetectable		 4w5qA-4g9zA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ILE A 484
GLN A 462
ILE A 467
ASP A 466
 None
G  F   6 ( 3.9A)
None
G  F   6 ( 4.6A)
 1.11A 4z4cA-4g9zA:
undetectable		 4z4cA-4g9zA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ILE A 484
GLN A 462
ILE A 467
ASP A 466
 None
G  F   6 ( 3.9A)
None
G  F   6 ( 4.6A)
 1.17A 4z4dA-4g9zA:
undetectable		 4z4dA-4g9zA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 4g9z NUCLEOPROTEIN
(Lassa
mammarenavirus) 		4 / 6 ARG A 476
ILE A 459
MET A 457
ASP A 478
 None
 1.49A 6dhbA-4g9zA:
undetectable		 6dhbA-4g9zA:
17.45