SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ga4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.06A 1dyiA-4ga4A:
undetectable
1dyiA-4ga4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.10A 1dyiB-4ga4A:
undetectable
1dyiB-4ga4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
4 / 6 ILE A 281
SER A 165
ASN A 172
THR A 174
None
PO4  A 601 (-4.6A)
None
None
1.00A 1h7xA-4ga4A:
3.3
1h7xA-4ga4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
4 / 6 ILE A 281
SER A 165
ASN A 172
THR A 174
None
PO4  A 601 (-4.6A)
None
None
1.01A 1h7xB-4ga4A:
3.3
1h7xB-4ga4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
4 / 6 ILE A 281
SER A 165
ASN A 172
THR A 174
None
PO4  A 601 (-4.6A)
None
None
1.00A 1h7xC-4ga4A:
1.8
1h7xC-4ga4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
4 / 6 ILE A 281
SER A 165
ASN A 172
THR A 174
None
PO4  A 601 (-4.6A)
None
None
0.99A 1h7xD-4ga4A:
3.2
1h7xD-4ga4A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 THR A 203
SER A 193
LEU A 357
VAL A 178
THR A 174
PO4  A 601 ( 3.9A)
PO4  A 601 (-2.9A)
None
None
None
1.22A 1q23B-4ga4A:
undetectable
1q23B-4ga4A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 11 THR A 203
SER A 193
LEU A 357
VAL A 178
THR A 174
PO4  A 601 ( 3.9A)
PO4  A 601 (-2.9A)
None
None
None
1.21A 1q23F-4ga4A:
undetectable
1q23F-4ga4A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.10A 1re7A-4ga4A:
undetectable
1re7A-4ga4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.12A 1tdrA-4ga4A:
undetectable
1tdrA-4ga4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_K_BO2K1402_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 10 ALA A 377
THR A 355
ALA A 354
ALA A 358
ALA A 386
None
1.03A 2f16K-4ga4A:
undetectable
2f16L-4ga4A:
undetectable
2f16K-4ga4A:
18.59
2f16L-4ga4A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_Y_BO2Y1403_1
(PROTEASOME COMPONENT
PRE2
PROTEASOME COMPONENT
C5)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 10 ALA A 377
THR A 355
ALA A 354
ALA A 358
ALA A 386
None
1.03A 2f16Y-4ga4A:
undetectable
2f16Z-4ga4A:
undetectable
2f16Y-4ga4A:
18.59
2f16Z-4ga4A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
4 / 5 PRO A 323
ILE A 428
GLY A 321
TYR A 319
None
0.95A 2jkjD-4ga4A:
undetectable
2jkjD-4ga4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
4 / 5 PRO A 323
ILE A 428
GLY A 321
TYR A 319
None
0.96A 2jkjF-4ga4A:
undetectable
2jkjF-4ga4A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 11 ASP A 301
ILE A 303
GLY A 306
LEU A 309
ILE A 279
None
0.88A 3em4A-4ga4A:
undetectable
3em4A-4ga4A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 GLY A 449
ILE A 176
GLY A 171
ARG A 335
ALA A 337
None
0.87A 3sudC-4ga4A:
undetectable
3sudC-4ga4A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.11A 4ej1B-4ga4A:
undetectable
4ej1B-4ga4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4D_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
4 / 8 THR A 192
THR A 188
VAL A 224
ASP A 162
None
1.15A 4l4dA-4ga4A:
undetectable
4l4dA-4ga4A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.11A 4qleA-4ga4A:
undetectable
4qleA-4ga4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.10A 4qlgB-4ga4A:
undetectable
4qlgB-4ga4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.13A 4x5fA-4ga4A:
undetectable
4x5fA-4ga4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.12A 4x5fB-4ga4A:
undetectable
4x5fB-4ga4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.14A 4x5gA-4ga4A:
undetectable
4x5gA-4ga4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.11A 4x5hA-4ga4A:
undetectable
4x5hA-4ga4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.11A 4x5jA-4ga4A:
undetectable
4x5jA-4ga4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
4 / 6 ALA A 249
SER A 264
ASP A 256
PRO A 257
None
0.97A 5c6pA-4ga4A:
undetectable
5c6pA-4ga4A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 450
LEU A 466
PHE A 467
THR A 487
ILE A 436
None
1.01A 5e8qA-4ga4A:
undetectable
5e8qA-4ga4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.11A 5e8qB-4ga4A:
undetectable
5e8qB-4ga4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 11 ASP A 119
VAL A  88
ILE A  91
ILE A 112
ILE A 245
None
1.12A 5hw8E-4ga4A:
undetectable
5hw8E-4ga4A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ASP A 119
VAL A  88
ILE A  91
ILE A 112
ILE A 245
None
1.09A 5hw8B-4ga4A:
undetectable
5hw8F-4ga4A:
undetectable
5hw8G-4ga4A:
undetectable
5hw8B-4ga4A:
15.46
5hw8F-4ga4A:
15.46
5hw8G-4ga4A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 9 ALA A 377
THR A 355
ALA A 354
ALA A 358
ALA A 386
None
1.10A 5l5zK-4ga4A:
undetectable
5l5zL-4ga4A:
undetectable
5l5zK-4ga4A:
18.84
5l5zL-4ga4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 9 ALA A 377
THR A 355
ALA A 354
ALA A 358
ALA A 386
None
1.10A 5l5zY-4ga4A:
undetectable
5l5zZ-4ga4A:
undetectable
5l5zY-4ga4A:
18.84
5l5zZ-4ga4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
4 / 8 SER A 383
ALA A 184
ALA A 358
LEU A 362
None
0.64A 5te8B-4ga4A:
undetectable
5te8B-4ga4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.11A 5ujxB-4ga4A:
undetectable
5ujxB-4ga4A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
None
1.14A 5z6fA-4ga4A:
undetectable
5z6fA-4ga4A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)
4ga4 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis)
4 / 5 GLY A 306
LEU A 305
TYR A 270
GLN A 311
None
1.15A 6ji6A-4ga4A:
undetectable
6ji6A-4ga4A:
18.42