SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ga6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 6 ILE A 281
SER A 165
ASN A 172
THR A 174
 None
SO4  A 602 ( 4.4A)
None
None
 1.00A 1h7xA-4ga6A:
4.3		 1h7xA-4ga6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 6 ILE A 281
SER A 165
ASN A 172
THR A 174
 None
SO4  A 602 ( 4.4A)
None
None
 1.01A 1h7xB-4ga6A:
2.5		 1h7xB-4ga6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 6 ILE A 281
SER A 165
ASN A 172
THR A 174
 None
SO4  A 602 ( 4.4A)
None
None
 1.01A 1h7xC-4ga6A:
undetectable		 1h7xC-4ga6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 6 ILE A 281
SER A 165
ASN A 172
THR A 174
 None
SO4  A 602 ( 4.4A)
None
None
 1.00A 1h7xD-4ga6A:
2.1		 1h7xD-4ga6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 GLU A 382
ALA A 340
LEU A 350
GLU A 352
ALA A 354
 None
 1.25A 1ie4A-4ga6A:
undetectable
1ie4C-4ga6A:
undetectable		 1ie4A-4ga6A:
12.93
1ie4C-4ga6A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 7 LEU A 305
ASP A 301
LEU A 298
MET A 136
 None
 1.06A 1n13I-4ga6A:
0.0
1n13L-4ga6A:
undetectable		 1n13I-4ga6A:
7.86
1n13L-4ga6A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 9 ALA A 145
ALA A 242
THR A 246
LEU A 260
LEU A 142
 None
 1.12A 1nr6A-4ga6A:
undetectable		 1nr6A-4ga6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 7 PHE A 417
ALA A 484
ILE A 490
ILE A 433
 None
 0.96A 1oniD-4ga6A:
undetectable
1oniF-4ga6A:
undetectable		 1oniD-4ga6A:
14.97
1oniF-4ga6A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 338
ALA A 340
LEU A 177
ILE A 394
ILE A 393
 None
 0.95A 1qknA-4ga6A:
undetectable		 1qknA-4ga6A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
 None
 1.09A 1tdrA-4ga6A:
undetectable		 1tdrA-4ga6A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 5 ILE A 324
LEU A 177
ALA A 337
GLU A 336
 None
 1.25A 1xvaA-4ga6A:
undetectable
1xvaB-4ga6A:
undetectable		 1xvaA-4ga6A:
20.24
1xvaB-4ga6A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 11 ALA A 377
ILE A 380
VAL A 178
LEU A 231
ILE A 189
 None
 1.22A 2h42A-4ga6A:
undetectable		 2h42A-4ga6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		3 / 3 ASN A 172
ILE A 197
MET A 261
 None
AMP  A 601 (-4.2A)
AMP  A 601 (-4.2A)
 0.66A 2h42C-4ga6A:
undetectable		 2h42C-4ga6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 11 LEU A 381
ALA A 358
ILE A 189
ALA A 386
ILE A 181
 None
 0.98A 2idwA-4ga6A:
3.0		 2idwA-4ga6A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 5 PRO A 323
ILE A 428
GLY A 321
TYR A 319
 None
 1.02A 2jkjD-4ga6A:
undetectable		 2jkjD-4ga6A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 5 PRO A 323
ILE A 428
GLY A 321
TYR A 319
 None
 1.02A 2jkjF-4ga6A:
undetectable		 2jkjF-4ga6A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 11 LYS A 191
LEU A 231
THR A 203
VAL A 163
ILE A 176
 SO4  A 602 (-2.9A)
None
SO4  A 602 ( 3.2A)
None
None
 1.34A 3bexE-4ga6A:
undetectable
3bexF-4ga6A:
undetectable		 3bexE-4ga6A:
20.00
3bexF-4ga6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 8 LEU A 361
ASN A 175
VAL A 178
GLY A 356
 None
SO4  A 602 (-3.8A)
None
None
 0.72A 3dcjB-4ga6A:
4.3		 3dcjB-4ga6A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 11 ASP A 301
ILE A 303
GLY A 306
LEU A 309
ILE A 279
 None
 0.93A 3em4A-4ga6A:
undetectable		 3em4A-4ga6A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A 328
GLY A 441
ARG A 251
ALA A 196
ALA A 201
 None
None
None
AMP  A 601 (-4.2A)
None
 1.09A 3keeB-4ga6A:
undetectable		 3keeB-4ga6A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 11 ILE A 492
GLY A 423
LEU A 466
THR A 421
ALA A 419
 None
 1.09A 3kw2A-4ga6A:
undetectable		 3kw2A-4ga6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 11 ILE A 492
GLY A 423
LEU A 466
THR A 421
ALA A 419
 None
 1.12A 3kw2B-4ga6A:
2.8		 3kw2B-4ga6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 344
GLU A 382
GLY A 348
LYS A 353
ALA A 354
 None
None
SO4  A 603 (-3.6A)
None
None
 1.31A 3qowA-4ga6A:
2.7		 3qowA-4ga6A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 449
ILE A 176
GLY A 171
ARG A 335
ALA A 337
 None
 0.93A 3sudC-4ga6A:
undetectable		 3sudC-4ga6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 8 ILE A 428
ASP A 429
ILE A 433
GLY A 171
 None
 0.73A 4acaC-4ga6A:
3.3		 4acaC-4ga6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 8 ILE A 428
ASP A 429
ILE A 433
GLY A 171
 None
 0.71A 4acbC-4ga6A:
3.2		 4acbC-4ga6A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 122
THR A 246
LEU A 260
LEU A 129
ILE A  91
 None
 0.97A 4c9lA-4ga6A:
undetectable		 4c9lA-4ga6A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 122
THR A 246
LEU A 260
LEU A 129
ILE A  91
 None
 0.99A 4c9lB-4ga6A:
undetectable		 4c9lB-4ga6A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 122
THR A 246
LEU A 260
LEU A 129
ILE A  91
 None
 0.96A 4c9oA-4ga6A:
undetectable		 4c9oA-4ga6A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 122
THR A 246
LEU A 260
LEU A 129
ILE A  91
 None
 0.98A 4c9oB-4ga6A:
undetectable		 4c9oB-4ga6A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA6_A_GA2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 9 GLY A 167
VAL A 169
GLU A 333
SER A 165
ASP A 280
 AMP  A 601 ( 3.7A)
None
None
SO4  A 602 ( 4.4A)
None
 1.43A 4da6A-4ga6A:
4.4		 4da6A-4ga6A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 279
ASP A 280
GLY A 167
ARG A 431
ILE A 166
 None
None
AMP  A 601 ( 3.7A)
None
None
 1.38A 4djfA-4ga6A:
undetectable		 4djfA-4ga6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A  60
ILE A   5
ALA A   3
VAL A  77
PHE A  71
 None
 1.16A 4dx5B-4ga6A:
3.3		 4dx5B-4ga6A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 469
ALA A 437
LEU A 452
PHE A 467
THR A 487
 None
 1.12A 4ej1B-4ga6A:
undetectable		 4ej1B-4ga6A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ARG A 157
LEU A 187
ILE A 189
CYH A 230
LEU A 231
 None
 1.25A 4k36A-4ga6A:
undetectable		 4k36A-4ga6A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ARG A 157
LEU A 187
ILE A 189
CYH A 230
LEU A 231
 None
 1.23A 4k36B-4ga6A:
undetectable		 4k36B-4ga6A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 8 THR A 192
THR A 188
VAL A 224
ASP A 162
 None
 1.08A 4l4eA-4ga6A:
undetectable		 4l4eA-4ga6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 8 THR A 192
THR A 188
VAL A 224
ASP A 162
 None
 1.06A 4l4fA-4ga6A:
undetectable		 4l4fA-4ga6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		6 / 12 ILE A  91
ASP A 244
ILE A 245
PHE A 125
LEU A 142
ILE A 108
 None
 1.50A 4m2xA-4ga6A:
undetectable		 4m2xA-4ga6A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A  60
ILE A   5
ALA A   3
VAL A  77
PHE A  71
 None
 1.14A 4u8vB-4ga6A:
2.9		 4u8vB-4ga6A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		4 / 6 ALA A 249
SER A 264
ASP A 256
PRO A 257
 None
AMP  A 601 (-2.5A)
AMP  A 601 (-3.2A)
None
 1.07A 5c6pA-4ga6A:
undetectable		 5c6pA-4ga6A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 450
LEU A 466
PHE A 467
THR A 487
ILE A 436
 None
 1.09A 5e8qA-4ga6A:
undetectable		 5e8qA-4ga6A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 334
ALA A 331
THR A 327
HIS A 326
ILE A 410
 None
None
None
SO4  A 603 (-3.7A)
None
 1.13A 5eeuF-4ga6A:
undetectable
5eeuG-4ga6A:
undetectable		 5eeuF-4ga6A:
13.33
5eeuG-4ga6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 334
ALA A 331
THR A 327
HIS A 326
ILE A 410
 None
None
None
SO4  A 603 (-3.7A)
None
 1.13A 5eevF-4ga6A:
undetectable
5eevG-4ga6A:
undetectable		 5eevF-4ga6A:
13.33
5eevG-4ga6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 334
ALA A 331
THR A 327
HIS A 326
ILE A 410
 None
None
None
SO4  A 603 (-3.7A)
None
 1.13A 5eewF-4ga6A:
undetectable
5eewG-4ga6A:
undetectable		 5eewF-4ga6A:
13.33
5eewG-4ga6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 334
ALA A 331
THR A 327
HIS A 326
ILE A 410
 None
None
None
SO4  A 603 (-3.7A)
None
 1.13A 5eexF-4ga6A:
undetectable
5eexG-4ga6A:
undetectable		 5eexF-4ga6A:
13.33
5eexG-4ga6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 334
ALA A 331
THR A 327
HIS A 326
ILE A 410
 None
None
None
SO4  A 603 (-3.7A)
None
 1.13A 5eeyF-4ga6A:
undetectable
5eeyG-4ga6A:
undetectable		 5eeyF-4ga6A:
13.33
5eeyG-4ga6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 334
ALA A 331
THR A 327
HIS A 326
ILE A 410
 None
None
None
SO4  A 603 (-3.7A)
None
 1.13A 5eezF-4ga6A:
undetectable
5eezG-4ga6A:
undetectable		 5eezF-4ga6A:
13.33
5eezG-4ga6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 334
ALA A 331
THR A 327
HIS A 326
ILE A 410
 None
None
None
SO4  A 603 (-3.7A)
None
 1.13A 5ef0F-4ga6A:
undetectable
5ef0G-4ga6A:
undetectable		 5ef0F-4ga6A:
13.33
5ef0G-4ga6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 334
ALA A 331
THR A 327
HIS A 326
ILE A 410
 None
None
None
SO4  A 603 (-3.7A)
None
 1.13A 5ef1F-4ga6A:
undetectable
5ef1G-4ga6A:
undetectable		 5ef1F-4ga6A:
13.33
5ef1G-4ga6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 334
ALA A 331
THR A 327
HIS A 326
ILE A 410
 None
None
None
SO4  A 603 (-3.7A)
None
 1.13A 5ef2F-4ga6A:
undetectable
5ef2G-4ga6A:
undetectable		 5ef2F-4ga6A:
13.33
5ef2G-4ga6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A 334
ALA A 331
THR A 327
HIS A 326
ILE A 410
 None
None
None
SO4  A 603 (-3.7A)
None
 1.13A 5ef3F-4ga6A:
undetectable
5ef3G-4ga6A:
undetectable		 5ef3F-4ga6A:
13.33
5ef3G-4ga6A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ASP A 119
VAL A  88
ILE A  91
ILE A 112
ILE A 245
 None
 1.11A 5hw8B-4ga6A:
undetectable
5hw8F-4ga6A:
undetectable
5hw8G-4ga6A:
undetectable		 5hw8B-4ga6A:
13.04
5hw8F-4ga6A:
13.04
5hw8G-4ga6A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 338
ALA A 340
LEU A 177
ILE A 394
LEU A 231
 None
 0.99A 5toaA-4ga6A:
undetectable		 5toaA-4ga6A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 ILE A 108
ILE A 122
VAL A 126
LEU A 129
ALA A 263
 None
 1.18A 6ajiA-4ga6A:
undetectable		 6ajiA-4ga6A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 9 ASN A 172
ILE A 247
SER A 165
SER A 193
GLY A 234
 None
None
SO4  A 602 ( 4.4A)
SO4  A 602 (-2.3A)
None
 1.29A 6awpA-4ga6A:
undetectable		 6awpA-4ga6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A 483
ILE A 436
LEU A 332
GLY A 441
ALA A 201
 None
 1.39A 6qyaB-4ga6A:
undetectable		 6qyaB-4ga6A:
22.33