SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ga7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 6 LEU A 373
LEU A  19
LEU A  17
LEU A 291
 None
 1.05A 2ab2A-4ga7A:
undetectable		 2ab2A-4ga7A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ASN A   8
ILE A  35
THR A   9
ALA A   7
VAL A 293
 None
 1.48A 2gl0D-4ga7A:
undetectable
2gl0E-4ga7A:
undetectable		 2gl0D-4ga7A:
18.13
2gl0E-4ga7A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_F_ADNF906_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		5 / 11 ASN A   8
ILE A  35
THR A   9
ALA A   7
VAL A 293
 None
 1.42A 2gl0D-4ga7A:
undetectable
2gl0F-4ga7A:
undetectable		 2gl0D-4ga7A:
18.13
2gl0F-4ga7A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 8 HIS A 364
SER A 367
ASP A  76
ARG A  69
 None
 1.21A 2rk8A-4ga7A:
undetectable		 2rk8A-4ga7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 7 HIS A 364
SER A 367
ASP A  76
ARG A  69
 None
 1.19A 2rk8B-4ga7A:
undetectable		 2rk8B-4ga7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 8 GLY A 292
PHE A  70
PHE A  58
PHE A  60
 None
 1.01A 3ko0B-4ga7A:
undetectable
3ko0J-4ga7A:
undetectable		 3ko0B-4ga7A:
14.47
3ko0J-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 8 GLY A 292
PHE A  70
PHE A  58
PHE A  60
 None
 0.98A 3ko0D-4ga7A:
undetectable
3ko0E-4ga7A:
undetectable		 3ko0D-4ga7A:
14.47
3ko0E-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 5 PHE A  33
PHE A  70
PHE A  11
PHE A  60
 None
 1.45A 3ko0F-4ga7A:
undetectable
3ko0G-4ga7A:
undetectable		 3ko0F-4ga7A:
14.47
3ko0G-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 8 GLY A 292
PHE A  70
PHE A  58
PHE A  60
 None
 1.05A 3ko0K-4ga7A:
undetectable
3ko0S-4ga7A:
undetectable		 3ko0K-4ga7A:
14.47
3ko0S-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 7 GLY A 292
PHE A  70
PHE A  58
PHE A  60
 None
 1.12A 3ko0L-4ga7A:
undetectable
3ko0N-4ga7A:
undetectable		 3ko0L-4ga7A:
14.47
3ko0N-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 8 GLY A 292
PHE A  70
PHE A  58
PHE A  60
 None
 1.01A 3ko0O-4ga7A:
undetectable
3ko0Q-4ga7A:
undetectable		 3ko0O-4ga7A:
14.47
3ko0Q-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 7 PHE A  58
PHE A  60
GLY A 292
PHE A  70
 None
 1.03A 3ko0K-4ga7A:
undetectable
3ko0S-4ga7A:
undetectable		 3ko0K-4ga7A:
14.47
3ko0S-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 7 PHE A  58
PHE A  60
GLY A 292
PHE A  70
 None
 1.06A 3ko0R-4ga7A:
undetectable
3ko0T-4ga7A:
undetectable		 3ko0R-4ga7A:
14.47
3ko0T-4ga7A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		5 / 11 GLY A  48
ARG A  47
LEU A 304
ILE A 132
LEU A 148
 None
 0.99A 4kt0A-4ga7A:
undetectable
4kt0J-4ga7A:
undetectable		 4kt0A-4ga7A:
19.92
4kt0J-4ga7A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		3 / 3 ARG A  10
HIS A  59
SER A   6
 None
 0.63A 4mjwA-4ga7A:
undetectable
4mjwB-4ga7A:
undetectable		 4mjwA-4ga7A:
19.68
4mjwB-4ga7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		3 / 3 SER A   6
ARG A  10
HIS A  59
 None
 0.67A 4mjwA-4ga7A:
undetectable
4mjwB-4ga7A:
undetectable		 4mjwA-4ga7A:
19.68
4mjwB-4ga7A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		5 / 9 THR A 251
ILE A 370
VAL A 216
LEU A 231
ILE A 209
 None
 1.32A 4r38C-4ga7A:
undetectable		 4r38C-4ga7A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		4 / 5 GLY A 330
TYR A  84
SER A  83
GLU A 329
 None
 1.37A 4xueA-4ga7A:
undetectable		 4xueA-4ga7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		5 / 12 ASN A 327
SER A 322
PHE A 360
PHE A 167
GLU A 329
 None
 1.32A 4zjlD-4ga7A:
undetectable		 4zjlD-4ga7A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens) 		5 / 10 ILE A 370
ALA A  12
ILE A  35
ILE A  30
ILE A 165
 None
 0.94A 5mvmD-4ga7A:
undetectable
5mvmE-4ga7A:
undetectable		 5mvmD-4ga7A:
12.27
5mvmE-4ga7A:
12.27