SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gaa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 5 LEU A 128
LEU A 112
SER A 103
LEU A  56
 None
 0.82A 1a4lC-4gaaA:
undetectable		 1a4lC-4gaaA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 LEU A 404
HIS A 317
LEU A 313
GLY A 383
PHE A 400
 None
 1.40A 1d4fA-4gaaA:
undetectable		 1d4fA-4gaaA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 10 LEU A 404
ASP A 243
GLY A 327
PRO A 397
PHE A 400
 None
 1.16A 1d4sA-4gaaA:
undetectable		 1d4sA-4gaaA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 ILE A 217
ILE A 290
PHE A 231
ILE A 257
THR A 215
 None
 1.05A 1dyrA-4gaaA:
undetectable		 1dyrA-4gaaA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.69A 1j36A-4gaaA:
3.3		 1j36A-4gaaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.69A 1j36B-4gaaA:
3.3		 1j36B-4gaaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.68A 1j37A-4gaaA:
3.2		 1j37A-4gaaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.69A 1j37B-4gaaA:
3.5		 1j37B-4gaaA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 GLY A 266
ARG A 534
VAL A 279
LEU A 286
ALA A 287
 BES  A 702 (-4.3A)
None
None
None
None
 0.94A 1jipA-4gaaA:
undetectable		 1jipA-4gaaA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 GLU A 235
ARG A 214
LEU A 238
GLU A 242
ALA A 241
 None
 1.30A 1mjlA-4gaaA:
undetectable
1mjlB-4gaaA:
0.4		 1mjlA-4gaaA:
11.54
1mjlB-4gaaA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.67A 1o86A-4gaaA:
3.3		 1o86A-4gaaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.91A 1v7zA-4gaaA:
undetectable		 1v7zA-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.91A 1v7zB-4gaaA:
undetectable		 1v7zB-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.92A 1v7zC-4gaaA:
undetectable		 1v7zC-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.93A 1v7zD-4gaaA:
undetectable		 1v7zD-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.93A 1v7zE-4gaaA:
undetectable		 1v7zE-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.92A 1v7zF-4gaaA:
undetectable		 1v7zF-4gaaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.62A 2c6nA-4gaaA:
3.3		 2c6nA-4gaaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.72A 2c6nB-4gaaA:
3.4		 2c6nB-4gaaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 7 GLY A 265
SER A 288
ARG A 560
GLU A 322
 BES  A 702 (-3.2A)
None
BES  A 702 (-4.0A)
BES  A 702 ( 4.6A)
 1.08A 2c8aD-4gaaA:
undetectable		 2c8aD-4gaaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 6 VAL A 369
THR A 307
SER A   5
ASP A   3
 None
 1.29A 2hdnJ-4gaaA:
undetectable
2hdnK-4gaaA:
undetectable
2hdnL-4gaaA:
undetectable		 2hdnJ-4gaaA:
21.05
2hdnK-4gaaA:
4.67
2hdnL-4gaaA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.60A 2x8zA-4gaaA:
5.8		 2x8zA-4gaaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.63A 2x91A-4gaaA:
3.4		 2x91A-4gaaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.92A 3a6jA-4gaaA:
undetectable		 3a6jA-4gaaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 7 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.90A 3a6jB-4gaaA:
undetectable		 3a6jB-4gaaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.91A 3a6jC-4gaaA:
undetectable		 3a6jC-4gaaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.93A 3a6jE-4gaaA:
undetectable		 3a6jE-4gaaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 GLU A 315
HIS A 292
HIS A 296
GLU A 293
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 3.4A)
BES  A 702 (-2.6A)
 0.90A 3a6jF-4gaaA:
undetectable		 3a6jF-4gaaA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 ILE A 140
LEU A 201
LEU A 128
VAL A  24
PRO A 142
 None
 1.26A 3dcjA-4gaaA:
undetectable
3dcjB-4gaaA:
undetectable		 3dcjA-4gaaA:
16.14
3dcjB-4gaaA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 LEU A 404
HIS A 317
LEU A 313
GLY A 383
PHE A 400
 None
 1.40A 3g1uA-4gaaA:
undetectable		 3g1uA-4gaaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 LEU A 404
HIS A 317
LEU A 313
GLY A 383
PHE A 400
 None
 1.44A 3g1uC-4gaaA:
undetectable		 3g1uC-4gaaA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_A_RABA602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 LEU A 404
HIS A 317
LEU A 313
GLY A 383
PHE A 400
 None
 1.33A 3glqA-4gaaA:
undetectable		 3glqA-4gaaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_1
(ADENOSYLHOMOCYSTEINA
SE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 LEU A 404
HIS A 317
LEU A 313
GLY A 383
PHE A 400
 None
 1.40A 3glqB-4gaaA:
undetectable		 3glqB-4gaaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 4 ILE A 217
PHE A 231
ILE A 257
THR A 215
 None
 0.89A 3ia4A-4gaaA:
undetectable		 3ia4A-4gaaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 4 ILE A 217
ARG A 560
ILE A 257
THR A 215
 None
BES  A 702 (-4.0A)
None
None
 1.09A 3ia4C-4gaaA:
undetectable		 3ia4C-4gaaA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 LEU A 404
HIS A 317
LEU A 313
GLY A 383
PHE A 400
 None
 1.29A 3n58A-4gaaA:
undetectable		 3n58A-4gaaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 7 MET A 517
LEU A 523
LEU A 509
PHE A 483
 None
 1.31A 3nk2X-4gaaA:
undetectable		 3nk2X-4gaaA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 5 GLY A 327
ASP A 326
ARG A 323
GLN A 495
 None
 1.46A 3qx3A-4gaaA:
undetectable		 3qx3A-4gaaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 10 ILE A 199
ASP A 145
THR A 304
SER A 415
ILE A 194
 None
 1.35A 3um5A-4gaaA:
undetectable		 3um5A-4gaaA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		3 / 3 ARG A 534
ARG A 537
ILE A 497
 None
 0.90A 4b7qC-4gaaA:
undetectable		 4b7qC-4gaaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 6 HIS A  23
SER A 158
GLU A 162
ASP A 180
 None
 1.16A 4blvA-4gaaA:
undetectable		 4blvA-4gaaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 HIS A 292
GLU A 293
HIS A 296
GLU A 315
TYR A 380
 ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 0.68A 4c2pA-4gaaA:
3.0		 4c2pA-4gaaA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9W_A_VGHA1158_1
(7,8-DIHYDRO-8-OXOGUA
NINE TRIPHOSPHATASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 LEU A 286
ASN A 528
PHE A 334
ASP A 283
GLN A 495
 None
 1.34A 4c9wA-4gaaA:
undetectable		 4c9wA-4gaaA:
14.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		8 / 9 TYR A 264
GLY A 265
HIS A 292
GLU A 293
GLU A 315
TYR A 380
ARG A 560
LYS A 562
 BES  A 702 (-3.3A)
BES  A 702 (-3.2A)
ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
BES  A 702 (-4.0A)
BES  A 702 ( 4.7A)
 0.54A 4dprA-4gaaA:
55.9		 4dprA-4gaaA:
67.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 9 TYR A 264
GLY A 266
HIS A 292
GLU A 315
TYR A 380
 BES  A 702 (-3.3A)
BES  A 702 (-4.3A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 1.7A)
BES  A 702 (-4.3A)
 1.03A 4dprA-4gaaA:
55.9		 4dprA-4gaaA:
67.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 7 PRO A 259
GLY A 204
ALA A 121
GLU A 220
 None
 0.89A 4g0uB-4gaaA:
undetectable		 4g0uB-4gaaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 6 PRO A 259
GLY A 204
ALA A 121
GLU A 220
 None
 0.96A 4g0uA-4gaaA:
undetectable		 4g0uA-4gaaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 5 THR A 299
THR A 418
LEU A 386
LEU A 387
 None
 0.98A 4lvcB-4gaaA:
undetectable		 4lvcB-4gaaA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 6 LEU A 387
HIS A 296
HIS A 292
GLU A 315
 None
ZN  A 701 ( 3.4A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 1.7A)
 0.91A 4pahA-4gaaA:
undetectable		 4pahA-4gaaA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		11 / 12 GLN A 133
ALA A 134
TYR A 264
HIS A 292
GLU A 293
HIS A 296
TRP A 308
PHE A 311
GLU A 315
LEU A 366
TYR A 380
 BES  A 702 (-3.2A)
BES  A 702 ( 4.4A)
BES  A 702 (-3.3A)
ZN  A 701 ( 3.2A)
BES  A 702 (-2.6A)
ZN  A 701 ( 3.4A)
None
BES  A 702 ( 4.9A)
ZN  A 701 ( 1.7A)
None
BES  A 702 (-4.3A)
 0.47A 4r7lA-4gaaA:
56.3		 4r7lA-4gaaA:
65.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 8 ASN A 269
MET A 267
TRP A 250
TYR A 248
 None
BES  A 702 (-3.4A)
None
None
 1.49A 4v30B-4gaaA:
undetectable		 4v30B-4gaaA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 5 SER A 492
ARG A 335
GLY A 331
GLU A 332
 None
 1.17A 5cdqA-4gaaA:
2.1
5cdqB-4gaaA:
undetectable
5cdqC-4gaaA:
2.2		 5cdqA-4gaaA:
22.14
5cdqB-4gaaA:
14.85
5cdqC-4gaaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 5 SER A 492
ARG A 335
GLY A 331
GLU A 332
 None
 1.16A 5cdqR-4gaaA:
undetectable
5cdqS-4gaaA:
undetectable
5cdqT-4gaaA:
undetectable		 5cdqR-4gaaA:
22.14
5cdqS-4gaaA:
14.85
5cdqT-4gaaA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		3 / 3 ARG A 171
THR A 216
ASP A 254
 None
 0.86A 5g5gA-4gaaA:
undetectable
5g5gB-4gaaA:
undetectable		 5g5gA-4gaaA:
17.29
5g5gB-4gaaA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 11 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
 None
 1.08A 5lg3A-4gaaA:
4.5		 5lg3A-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
 None
 1.04A 5lg3E-4gaaA:
4.3		 5lg3E-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 10 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
 None
 1.06A 5lg3F-4gaaA:
3.4		 5lg3F-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 10 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
 None
 1.06A 5lg3G-4gaaA:
2.4		 5lg3G-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 10 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
 None
 1.05A 5lg3H-4gaaA:
0.3		 5lg3H-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 ILE A 257
ILE A 217
VAL A 275
THR A 273
ILE A 290
 None
 1.09A 5lg3J-4gaaA:
3.4		 5lg3J-4gaaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 4 HIS A 296
HIS A 292
TYR A 380
GLU A 315
 ZN  A 701 ( 3.4A)
ZN  A 701 ( 3.2A)
BES  A 702 (-4.3A)
ZN  A 701 ( 1.7A)
 1.40A 5pahA-4gaaA:
undetectable		 5pahA-4gaaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 10 ALA A 287
LEU A 255
TYR A 253
VAL A 275
GLY A 266
 None
None
None
None
BES  A 702 (-4.3A)
 1.28A 5zbdA-4gaaA:
undetectable		 5zbdA-4gaaA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		3 / 3 GLN A 133
TRP A 308
VAL A 371
 BES  A 702 (-3.2A)
None
None
 0.94A 6auuA-4gaaA:
undetectable		 6auuA-4gaaA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 9 PHE A 585
VAL A 600
ILE A 548
ARG A 569
ASP A 570
 None
 1.36A 6c2mC-4gaaA:
undetectable		 6c2mC-4gaaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_1
(-)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		5 / 12 LEU A 404
HIS A 317
LEU A 313
GLY A 383
PHE A 400
 None
 1.24A 6gbnB-4gaaA:
undetectable		 6gbnB-4gaaA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 5 LEU A  20
GLN A 156
PHE A 188
PHE A 151
 None
 1.43A 6nmpP-4gaaA:
undetectable
6nmpW-4gaaA:
undetectable		 6nmpP-4gaaA:
17.83
6nmpW-4gaaA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 4gaa MGC78867 PROTEIN
(Xenopus
laevis) 		4 / 6 LEU A 387
HIS A 296
HIS A 292
GLU A 315
 None
ZN  A 701 ( 3.4A)
ZN  A 701 ( 3.2A)
ZN  A 701 ( 1.7A)
 0.95A 6pahA-4gaaA:
undetectable		 6pahA-4gaaA:
19.83