SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 4gah THIOESTERASE
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		3 / 3 PHE A  61
TRP A  53
GLU A 122
 None
 1.07A 1mogA-4gahA:
1.6		 1mogA-4gahA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_2
(PROTEASE)		 4gah THIOESTERASE
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		5 / 12 GLY A 154
ALA A 157
ASP A 161
ILE A 188
ILE A 182
 None
None
0ET  A 301 (-3.6A)
None
None
 0.96A 2ienB-4gahA:
undetectable		 2ienB-4gahA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 4gah THIOESTERASE
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		3 / 3 ARG A  75
GLU A 122
ASP A 116
 None
 0.87A 3g2oA-4gahA:
undetectable		 3g2oA-4gahA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 4gah THIOESTERASE
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		5 / 12 GLY A 154
ALA A 157
ASP A 161
ILE A 188
ILE A 182
 None
None
0ET  A 301 (-3.6A)
None
None
 0.98A 3mwsA-4gahA:
undetectable		 3mwsA-4gahA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4gah THIOESTERASE
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		5 / 10 ILE A 188
VAL A 214
SER A 224
TYR A 184
ILE A 182
 None
 1.07A 3uprA-4gahA:
undetectable		 3uprA-4gahA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 4gah THIOESTERASE
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		5 / 12 ILE A 188
VAL A 214
SER A 224
TYR A 184
ILE A 182
 None
 1.08A 3vrjA-4gahA:
undetectable
3vrjC-4gahA:
undetectable		 3vrjA-4gahA:
18.47
3vrjC-4gahA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 4gah THIOESTERASE
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		5 / 12 GLY A 154
ALA A 157
ASP A 161
ILE A 188
ILE A 182
 None
None
0ET  A 301 (-3.6A)
None
None
 1.03A 4njvA-4gahA:
undetectable		 4njvA-4gahA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 4gah THIOESTERASE
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		5 / 12 GLY A 154
ALA A 157
ASP A 161
ILE A 188
ILE A 182
 None
None
0ET  A 301 (-3.6A)
None
None
 1.07A 4njvD-4gahA:
undetectable		 4njvD-4gahA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4gah THIOESTERASE
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		5 / 10 ILE A 188
VAL A 214
SER A 224
TYR A 184
ILE A 182
 None
 1.10A 5u98A-4gahA:
undetectable		 5u98A-4gahA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 4gah THIOESTERASE
SUPERFAMILY MEMBER 4
(Homo
sapiens) 		5 / 10 ILE A 188
VAL A 214
SER A 224
TYR A 184
ILE A 182
 None
 1.09A 5u98D-4gahA:
undetectable		 5u98D-4gahA:
18.40