SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		4 / 6 ILE A 127
LEU A 130
LEU A  49
ASP A  48
 None
 0.95A 2rlfA-4gakA:
undetectable
2rlfD-4gakA:
undetectable		 2rlfA-4gakA:
10.25
2rlfD-4gakA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		4 / 7 ILE A 200
LEU A 202
PHE A  61
LEU A 139
 None
 0.96A 3adxA-4gakA:
undetectable		 3adxA-4gakA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		5 / 12 ASP A  85
PHE A  88
ILE A  89
ASP A 125
LEU A 123
 None
None
GOL  A 302 ( 4.9A)
None
None
 1.27A 3iv6B-4gakA:
undetectable		 3iv6B-4gakA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		4 / 6 VAL A 226
HIS A 228
SER A 218
THR A 220
 None
 0.50A 3tj7A-4gakA:
undetectable
3tj7B-4gakA:
undetectable		 3tj7A-4gakA:
21.32
3tj7B-4gakA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		4 / 6 VAL A 226
HIS A 228
SER A 218
THR A 220
 None
 0.52A 3tj7C-4gakA:
undetectable
3tj7D-4gakA:
undetectable		 3tj7C-4gakA:
21.32
3tj7D-4gakA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		4 / 6 VAL A 226
HIS A 228
SER A 218
THR A 220
 None
 0.54A 3tj7C-4gakA:
undetectable
3tj7D-4gakA:
undetectable		 3tj7C-4gakA:
21.32
3tj7D-4gakA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		4 / 8 TRP A 110
THR A 109
TYR A 204
LEU A 111
 GOL  A 302 ( 4.1A)
None
None
None
 1.15A 3wipG-4gakA:
undetectable
3wipH-4gakA:
undetectable		 3wipG-4gakA:
23.64
3wipH-4gakA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_B_DXCB1473_0
(MJ0495-LIKE PROTEIN)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		5 / 11 ASP A  48
ILE A  44
GLY A  43
VAL A  84
GLN A 129
 None
 0.85A 4ac9B-4gakA:
undetectable
4ac9C-4gakA:
undetectable		 4ac9B-4gakA:
19.21
4ac9C-4gakA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		5 / 9 ASP A  48
ILE A  44
GLY A  43
VAL A  84
GLN A 129
 None
 0.89A 4acaB-4gakA:
undetectable
4acaC-4gakA:
undetectable		 4acaB-4gakA:
19.21
4acaC-4gakA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CU6_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		4 / 6 ILE A  65
VAL A  95
PRO A  69
ALA A 104
 None
 0.84A 5cu6A-4gakA:
undetectable		 5cu6A-4gakA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		4 / 5 THR A  83
THR A  82
TYR A  80
HIS A  90
 None
 1.14A 5ecmA-4gakA:
undetectable		 5ecmA-4gakA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4gak ACYL-ACP
THIOESTERASE
(Spirosoma
linguale) 		4 / 8 LEU A  58
PHE A  61
ALA A  35
PHE A  93
 None
None
GOL  A 302 (-3.6A)
None
 0.69A 5m0oC-4gakA:
undetectable		 5m0oC-4gakA:
21.03