SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		4 / 5 GLU A  69
LEU A  63
LEU A  66
LEU A  64
 None
 1.05A 1np1A-4gaxA:
undetectable		 1np1A-4gaxA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		6 / 12 ALA A 258
LEU A 294
LEU A 297
ILE A 298
ILE A 301
LEU A 339
 None
 1.48A 1xdkF-4gaxA:
undetectable		 1xdkF-4gaxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		4 / 4 LEU A 109
PRO A 503
ILE A  83
LEU A  87
 None
 1.10A 1ya4C-4gaxA:
2.5		 1ya4C-4gaxA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		3 / 3 TRP A  20
GLU A 267
TYR A 532
 None
 1.21A 2a3aA-4gaxA:
undetectable		 2a3aA-4gaxA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		4 / 6 ARG A 262
PHE A 525
THR A 296
VAL A 295
 None
 1.08A 2e1qA-4gaxA:
1.9		 2e1qA-4gaxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		3 / 3 LEU A 495
ASN A 491
ARG A 111
 None
 0.78A 2qhfA-4gaxA:
undetectable		 2qhfA-4gaxA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2001_1
(SERUM ALBUMIN)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 12 ARG A 153
PRO A 155
PHE A 116
TYR A 494
ILE A 509
 None
 1.41A 2vufB-4gaxA:
undetectable		 2vufB-4gaxA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 12 THR A 408
VAL A 291
PHE A 340
TRP A 321
GLY A 363
 None
 1.15A 2x2iA-4gaxA:
undetectable		 2x2iA-4gaxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 10 THR A 408
VAL A 291
PHE A 340
TRP A 321
GLY A 363
 None
 1.20A 2x2iB-4gaxA:
undetectable		 2x2iB-4gaxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 10 THR A 408
VAL A 291
PHE A 340
TRP A 321
GLY A 363
 None
 1.16A 2x2iD-4gaxA:
undetectable		 2x2iD-4gaxA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 12 VAL A 517
PHE A 525
VAL A 295
LEU A 404
ILE A 292
 None
 1.27A 3elzC-4gaxA:
undetectable		 3elzC-4gaxA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		3 / 3 ASP A  55
LEU A  54
GLN A  81
 None
 0.79A 3g4lA-4gaxA:
undetectable		 3g4lA-4gaxA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 11 ALA A 175
LEU A 193
LEU A 144
VAL A 140
THR A 178
 None
 1.19A 3jw5A-4gaxA:
undetectable		 3jw5A-4gaxA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 10 ALA A 175
LEU A 193
LEU A 144
VAL A 140
THR A 178
 None
 1.16A 3jw5B-4gaxA:
undetectable		 3jw5B-4gaxA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		3 / 3 HIS A  89
HIS A  60
ILE A  90
 None
 0.85A 3u52A-4gaxA:
undetectable
3u52C-4gaxA:
1.9		 3u52A-4gaxA:
21.52
3u52C-4gaxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		3 / 3 TYR A  77
GLU A 205
TYR A 209
 None
 0.90A 3ug8A-4gaxA:
undetectable		 3ug8A-4gaxA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		4 / 5 LEU A 326
ALA A 317
MET A 341
PHE A 314
 None
 1.18A 3vasB-4gaxA:
undetectable		 3vasB-4gaxA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 12 ALA A 227
GLU A 230
PHE A 231
LEU A 233
LEU A 234
 None
 0.74A 4i1rA-4gaxA:
undetectable		 4i1rA-4gaxA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 10 CYH A 119
LEU A 160
ALA A 163
HIS A 125
LEU A 146
 None
 1.27A 4p65A-4gaxA:
undetectable
4p65B-4gaxA:
undetectable
4p65F-4gaxA:
undetectable
4p65H-4gaxA:
undetectable		 4p65A-4gaxA:
2.90
4p65B-4gaxA:
4.32
4p65F-4gaxA:
4.32
4p65H-4gaxA:
4.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		3 / 3 ASP A 415
ARG A 276
PRO A 503
 None
 0.84A 4wanC-4gaxA:
undetectable		 4wanC-4gaxA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 9 LEU A 495
LEU A 160
GLU A 157
VAL A 121
VAL A 117
 None
 1.45A 4wnvB-4gaxA:
undetectable		 4wnvB-4gaxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 4gax AMORPHA-4,11-DIENE
SYNTHASE
(Artemisia
annua) 		5 / 9 LEU A 311
ARG A 372
PHE A 370
THR A 296
ASP A 300
 None
 1.40A 5gpgB-4gaxA:
2.2		 5gpgB-4gaxA:
11.52