SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gb7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		5 / 12 PHE A 124
ILE A 386
VAL A 119
ASN A  82
LEU A 102
 None
 1.27A 1fm4A-4gb7A:
undetectable		 1fm4A-4gb7A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_A_BEZA349_0
(D-AMINO ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.14A 1kifA-4gb7A:
undetectable		 1kifA-4gb7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_B_BEZB349_0
(D-AMINO ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.14A 1kifB-4gb7A:
undetectable		 1kifB-4gb7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_C_BEZC349_0
(D-AMINO ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.15A 1kifC-4gb7A:
undetectable		 1kifC-4gb7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_D_BEZD349_0
(D-AMINO ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.14A 1kifD-4gb7A:
undetectable		 1kifD-4gb7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_E_BEZE349_0
(D-AMINO ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.14A 1kifE-4gb7A:
undetectable		 1kifE-4gb7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_F_BEZF349_0
(D-AMINO ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.14A 1kifF-4gb7A:
undetectable		 1kifF-4gb7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_G_BEZG349_0
(D-AMINO ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.14A 1kifG-4gb7A:
undetectable		 1kifG-4gb7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIF_H_BEZH349_0
(D-AMINO ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.14A 1kifH-4gb7A:
undetectable		 1kifH-4gb7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 6 TYR A 123
TYR A 127
GLU A 121
VAL A 387
 None
 1.30A 1q13A-4gb7A:
undetectable		 1q13A-4gb7A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 7 LEU A 215
THR A  61
LEU A 210
VAL A 287
 None
 0.98A 1tyrB-4gb7A:
undetectable		 1tyrB-4gb7A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE9_A_BEZA352_0
(D-AMINO ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.13A 1ve9A-4gb7A:
undetectable		 1ve9A-4gb7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.20A 2du8G-4gb7A:
undetectable		 2du8G-4gb7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.19A 2du8J-4gb7A:
undetectable		 2du8J-4gb7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 7 GLN A 295
LEU A 208
ASP A 205
LEU A 201
 None
 1.00A 2qqcB-4gb7A:
undetectable
2qqcC-4gb7A:
undetectable		 2qqcB-4gb7A:
13.30
2qqcC-4gb7A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_A_AG2A672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 7 LEU A 208
ASP A 205
LEU A 201
GLN A 295
 None
 1.00A 2qqcA-4gb7A:
undetectable
2qqcF-4gb7A:
undetectable		 2qqcA-4gb7A:
13.85
2qqcF-4gb7A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 7 GLN A 295
LEU A 208
ASP A 205
LEU A 201
 None
 0.96A 2qqcD-4gb7A:
undetectable
2qqcE-4gb7A:
undetectable		 2qqcD-4gb7A:
13.30
2qqcE-4gb7A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 7 LEU A 208
ASP A 205
LEU A 201
GLN A 295
 None
 0.98A 2qqcG-4gb7A:
undetectable
2qqcJ-4gb7A:
undetectable		 2qqcG-4gb7A:
13.85
2qqcJ-4gb7A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_I_AG2I672_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 7 LEU A 208
ASP A 205
LEU A 201
GLN A 295
 None
 0.95A 2qqcI-4gb7A:
undetectable
2qqcL-4gb7A:
undetectable		 2qqcI-4gb7A:
13.85
2qqcL-4gb7A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 5 TYR A 196
TYR A 209
TYR A 372
HIS A 198
 None
 1.49A 2v0gD-4gb7A:
undetectable		 2v0gD-4gb7A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		5 / 12 MET A 135
PHE A 389
ALA A 296
ALA A 304
ALA A 308
 None
 1.33A 2x2nA-4gb7A:
undetectable		 2x2nA-4gb7A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		5 / 12 THR A 291
LEU A 231
GLN A 207
LEU A 208
TYR A 228
 None
 1.44A 3fsuA-4gb7A:
undetectable		 3fsuA-4gb7A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		6 / 12 ALA A 136
SER A 137
LYS A 140
ASN A 248
LEU A 208
GLY A 370
 None
NO3  A 601 (-3.2A)
None
None
None
NO3  A 601 (-3.3A)
 1.13A 3mzeA-4gb7A:
13.6		 3mzeA-4gb7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		5 / 12 TYR A 246
TYR A 352
GLY A 249
SER A 250
LEU A 208
 NO3  A 601 (-4.3A)
None
None
None
None
 1.45A 3ou6D-4gb7A:
undetectable		 3ou6D-4gb7A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 8 TYR A 191
LEU A 208
ALA A 298
SER A 137
 None
None
None
NO3  A 601 (-3.2A)
 1.10A 3rodA-4gb7A:
undetectable		 3rodA-4gb7A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 6 ASP A 163
THR A 260
ILE A 257
THR A 172
 None
 1.06A 4acbC-4gb7A:
undetectable		 4acbC-4gb7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		3 / 3 ASP A  46
HIS A 198
LYS A  42
 None
 0.96A 4qzuD-4gb7A:
undetectable		 4qzuD-4gb7A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 7 ILE A 325
GLN A 324
PRO A 327
ILE A 330
 None
 1.09A 4w5oA-4gb7A:
undetectable		 4w5oA-4gb7A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		5 / 12 THR A 161
ALA A 162
ASP A 163
LEU A 169
PRO A 173
 None
 1.33A 4xi3A-4gb7A:
undetectable		 4xi3A-4gb7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		6 / 12 THR A 161
ALA A 162
ASP A 163
LEU A 169
GLY A 241
PRO A 173
 None
 1.40A 4xi3B-4gb7A:
undetectable		 4xi3B-4gb7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		6 / 12 THR A 161
ALA A 162
ASP A 163
LEU A 182
GLY A 241
PRO A 173
 None
 1.18A 4xi3B-4gb7A:
undetectable		 4xi3B-4gb7A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJO_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		5 / 12 MET A 280
ALA A 284
GLU A 252
LEU A 266
THR A 251
 None
 1.13A 4zjoA-4gb7A:
undetectable		 4zjoA-4gb7A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_B_RBFB201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 7 VAL A 287
TYR A  54
LEU A 201
TRP A  44
 None
 0.98A 5umwB-4gb7A:
undetectable
5umwE-4gb7A:
undetectable		 5umwB-4gb7A:
13.18
5umwE-4gb7A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMW_F_RBFF201_1
(GLYOXALASE/BLEOMYCIN
RESISANCE
PROTEIN/DIOXYGENASE)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 7 LEU A 201
TRP A  44
VAL A 287
TYR A  54
 None
 1.09A 5umwA-4gb7A:
undetectable
5umwF-4gb7A:
undetectable		 5umwA-4gb7A:
13.18
5umwF-4gb7A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE
(Bacillus
anthracis) 		4 / 6 ASN A 125
ASP A 108
SER A 391
ARG A  51
 None
 1.14A 6dwdA-4gb7A:
undetectable
6dwdC-4gb7A:
undetectable		 6dwdA-4gb7A:
22.43
6dwdC-4gb7A:
22.43