SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gbs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4gbs PUTATIVE LIPOPROTEIN
(Bacteroides
fragilis) 		5 / 10 MET A 190
LEU A 187
ALA A 197
HIS A  71
LEU A  70
 None
 1.22A 1gwrA-4gbsA:
undetectable		 1gwrA-4gbsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 4gbs PUTATIVE LIPOPROTEIN
(Bacteroides
fragilis) 		4 / 5 ASP A 216
LEU A  70
ALA A 197
LEU A 115
 None
None
None
SO4  A 301 (-3.9A)
 1.13A 1nh8A-4gbsA:
undetectable		 1nh8A-4gbsA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 4gbs PUTATIVE LIPOPROTEIN
(Bacteroides
fragilis) 		3 / 3 GLU A  36
LYS A  40
ASN A 205
 None
MLY  A  39 ( 3.3A)
None
 1.10A 4y1dA-4gbsA:
undetectable
4y1dD-4gbsA:
undetectable		 4y1dA-4gbsA:
21.43
4y1dD-4gbsA:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gbs PUTATIVE LIPOPROTEIN
(Bacteroides
fragilis) 		4 / 7 TYR A 219
PHE A 215
ILE A 198
PHE A  43
 None
 0.88A 4ze3A-4gbsA:
undetectable		 4ze3A-4gbsA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gbs PUTATIVE LIPOPROTEIN
(Bacteroides
fragilis) 		4 / 8 TYR A 219
PHE A 215
ILE A 198
PHE A  43
 None
 0.92A 5esfA-4gbsA:
undetectable		 5esfA-4gbsA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4gbs PUTATIVE LIPOPROTEIN
(Bacteroides
fragilis) 		4 / 8 TYR A 219
PHE A 215
ILE A 198
PHE A  43
 None
 0.85A 5esjA-4gbsA:
undetectable		 5esjA-4gbsA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4gbs PUTATIVE LIPOPROTEIN
(Bacteroides
fragilis) 		5 / 11 MET A 190
LEU A 187
ALA A 197
HIS A  71
LEU A  70
 None
 1.24A 5hyrB-4gbsA:
undetectable		 5hyrB-4gbsA:
21.92