SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gc5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 8 GLU A  61
GLY A  63
GLU A  85
ASP A 111
 None
ACT  A 402 (-3.4A)
ACT  A 402 (-2.9A)
None
 0.53A 1jg4A-4gc5A:
9.2		 1jg4A-4gc5A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		8 / 12 PHE A  37
GLU A  61
GLY A  63
GLY A  65
ASP A  87
ASP A 111
ASN A 141
PRO A 143
 None
None
ACT  A 402 (-3.4A)
None
None
None
None
ACT  A 402 ( 4.9A)
 0.69A 1qaoA-4gc5A:
22.3		 1qaoA-4gc5A:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		3 / 3 ASP A  40
LYS A  46
ARG A  49
 None
 1.12A 1ra8A-4gc5A:
undetectable		 1ra8A-4gc5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  67
GLY A  68
ASP A  87
ASP A 111
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.74A 1sqfA-4gc5A:
10.4		 1sqfA-4gc5A:
22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
ASP A 111
LEU A 142
PRO A 143
PHE A 217
 ACT  A 402 (-3.4A)
None
None
None
ACT  A 402 ( 4.9A)
None
 1.03A 1zq9B-4gc5A:
25.0		 1zq9B-4gc5A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		7 / 12 GLY A  65
ASP A 111
VAL A 112
ASN A 141
LEU A 142
PRO A 143
PHE A 217
 None
None
None
None
None
ACT  A 402 ( 4.9A)
None
 0.94A 1zq9B-4gc5A:
25.0		 1zq9B-4gc5A:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 11 GLU A  61
GLU A  85
ASP A  87
ASP A 111
PRO A 143
 None
ACT  A 402 (-2.9A)
None
None
ACT  A 402 ( 4.9A)
 0.89A 2admA-4gc5A:
11.7		 2admA-4gc5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 ILE A 152
ILE A 151
LEU A 196
VAL A 206
ILE A 198
 None
 0.97A 2nnhA-4gc5A:
undetectable		 2nnhA-4gc5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 10 ILE A 152
ILE A 151
LEU A 196
VAL A 206
ILE A 198
 None
 1.03A 2nnhB-4gc5A:
undetectable		 2nnhB-4gc5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
ASP A  87
ASN A 141
LEU A 142
 ACT  A 402 (-3.4A)
None
None
None
None
 0.44A 2nxeB-4gc5A:
13.1		 2nxeB-4gc5A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.64A 2pxcA-4gc5A:
8.3		 2pxcA-4gc5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 LEU A  43
ILE A  47
LEU A  38
ALA A 216
HIS A 208
 None
 1.25A 2qo6A-4gc5A:
undetectable		 2qo6A-4gc5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 THR A 148
PRO A 149
VAL A 146
SER A 147
 None
 1.01A 2v2gA-4gc5A:
undetectable
2v2gB-4gc5A:
undetectable		 2v2gA-4gc5A:
20.34
2v2gB-4gc5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 THR A 148
PRO A 149
VAL A 146
SER A 147
 None
 1.02A 2v2gA-4gc5A:
undetectable
2v2gB-4gc5A:
undetectable		 2v2gA-4gc5A:
20.34
2v2gB-4gc5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 THR A 148
PRO A 149
VAL A 146
SER A 147
 None
 1.02A 2v2gC-4gc5A:
undetectable
2v2gD-4gc5A:
undetectable		 2v2gC-4gc5A:
20.34
2v2gD-4gc5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 THR A 148
PRO A 149
VAL A 146
SER A 147
 None
 1.01A 2v2gC-4gc5A:
undetectable
2v2gD-4gc5A:
undetectable		 2v2gC-4gc5A:
20.34
2v2gD-4gc5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 8 THR A 148
PRO A 149
VAL A 146
SER A 147
 None
 0.99A 2v32C-4gc5A:
undetectable
2v32D-4gc5A:
undetectable		 2v32C-4gc5A:
20.34
2v32D-4gc5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 8 THR A 148
PRO A 149
VAL A 146
SER A 147
 None
 1.03A 2v41C-4gc5A:
undetectable
2v41D-4gc5A:
undetectable		 2v41C-4gc5A:
20.34
2v41D-4gc5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 THR A 148
PRO A 149
VAL A 146
SER A 147
 None
 1.08A 2v41E-4gc5A:
undetectable
2v41F-4gc5A:
undetectable		 2v41E-4gc5A:
20.34
2v41F-4gc5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 8 THR A 148
PRO A 149
VAL A 146
SER A 147
 None
 1.03A 2v41G-4gc5A:
undetectable
2v41H-4gc5A:
undetectable		 2v41G-4gc5A:
20.34
2v41H-4gc5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 9 THR A  70
VAL A  83
GLY A  93
PHE A  90
ILE A  91
 None
 1.16A 2w98A-4gc5A:
6.4		 2w98A-4gc5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  65
GLY A  68
LEU A 113
ASN A 141
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.91A 2y7hB-4gc5A:
9.2		 2y7hB-4gc5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  65
GLY A  68
LEU A 113
ASN A 141
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.92A 2y7hC-4gc5A:
10.4		 2y7hC-4gc5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
ASP A  87
ASN A 141
LEU A 142
 ACT  A 402 (-3.4A)
None
None
None
None
 0.50A 2zbpA-4gc5A:
12.8		 2zbpA-4gc5A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
ASP A  87
ASN A 141
LEU A 142
 ACT  A 402 (-3.4A)
None
None
None
None
 0.50A 3cjtG-4gc5A:
12.6		 3cjtG-4gc5A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
ASP A 111
ASN A 141
PRO A 143
VAL A 146
 ACT  A 402 (-3.4A)
None
None
None
ACT  A 402 ( 4.9A)
None
 0.96A 3dmfA-4gc5A:
12.2		 3dmfA-4gc5A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
ASN A 141
PRO A 143
VAL A 146
 ACT  A 402 (-3.4A)
None
None
ACT  A 402 ( 4.9A)
None
 1.00A 3dmhA-4gc5A:
12.3		 3dmhA-4gc5A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 11 GLU A  61
GLY A  63
GLY A  65
GLU A  85
ASP A 111
 None
ACT  A 402 (-3.4A)
None
ACT  A 402 (-2.9A)
None
 0.61A 3dxyA-4gc5A:
9.2		 3dxyA-4gc5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 ILE A  91
GLY A  63
TYR A 115
LEU A 105
 None
ACT  A 402 (-3.4A)
None
None
 0.92A 3elzA-4gc5A:
undetectable		 3elzA-4gc5A:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		7 / 12 GLY A  63
GLY A  65
GLU A  85
LYS A  86
ASP A  87
ASP A 111
PRO A 143
 ACT  A 402 (-3.4A)
None
ACT  A 402 (-2.9A)
None
None
None
ACT  A 402 ( 4.9A)
 1.14A 3fuuA-4gc5A:
25.0		 3fuuA-4gc5A:
31.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		7 / 12 VAL A  62
GLY A  63
GLY A  65
GLU A  85
LYS A  86
ASP A  87
ASP A 111
 None
ACT  A 402 (-3.4A)
None
ACT  A 402 (-2.9A)
None
None
None
 0.75A 3fuuA-4gc5A:
25.0		 3fuuA-4gc5A:
31.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.47A 3gczA-4gc5A:
8.4		 3gczA-4gc5A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		7 / 11 GLY A  63
GLY A  65
GLU A  85
ASP A  87
ASP A 111
ASN A 141
PRO A 143
 ACT  A 402 (-3.4A)
None
ACT  A 402 (-2.9A)
None
None
None
ACT  A 402 ( 4.9A)
 1.11A 3grvA-4gc5A:
26.2		 3grvA-4gc5A:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		8 / 12 LEU A  38
GLU A  61
GLY A  63
GLY A  65
GLU A  85
ASP A  87
ASP A 111
ASN A 141
 None
None
ACT  A 402 (-3.4A)
None
ACT  A 402 (-2.9A)
None
None
None
 0.73A 3gryA-4gc5A:
26.0		 3gryA-4gc5A:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		8 / 12 LEU A  38
GLY A  63
GLY A  65
GLU A  85
ASP A  87
ASP A 111
ASN A 141
PRO A 143
 None
ACT  A 402 (-3.4A)
None
ACT  A 402 (-2.9A)
None
None
None
ACT  A 402 ( 4.9A)
 1.06A 3gryA-4gc5A:
26.0		 3gryA-4gc5A:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  67
ASP A 111
LEU A 142
 ACT  A 402 (-3.4A)
None
None
None
None
 0.61A 3ihtA-4gc5A:
9.0		 3ihtA-4gc5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 TYR A 320
GLU A 324
LEU A 267
ASN A 251
 None
 1.32A 3k8mA-4gc5A:
undetectable		 3k8mA-4gc5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.90A 3p97A-4gc5A:
8.5		 3p97A-4gc5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.67A 3p97C-4gc5A:
8.5		 3p97C-4gc5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
ILE A  69
ASP A 111
ASN A 141
PRO A 143
 ACT  A 402 (-3.4A)
None
None
None
ACT  A 402 ( 4.9A)
 0.80A 3q87B-4gc5A:
12.2		 3q87B-4gc5A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLU A  61
GLY A  63
GLY A  65
LYS A  86
ASP A 111
VAL A 112
 None
ACT  A 402 (-3.4A)
None
None
None
None
 0.82A 3sglA-4gc5A:
8.6		 3sglA-4gc5A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 LEU A  38
GLY A  65
LYS A  86
ASN A 141
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.91A 3tm4A-4gc5A:
14.1		 3tm4A-4gc5A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 LEU A  38
GLY A  65
LYS A  86
ASN A 141
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.96A 3tm4B-4gc5A:
14.1		 3tm4B-4gc5A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  65
ASP A  87
VAL A 112
ASN A 141
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.85A 3v8vA-4gc5A:
15.0		 3v8vA-4gc5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 11 GLY A  65
ASP A  87
ASP A 111
VAL A 112
ASN A 141
PRO A 143
 None
None
None
None
None
ACT  A 402 ( 4.9A)
 1.00A 3v8vB-4gc5A:
10.7		 3v8vB-4gc5A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
PRO A  66
GLY A  67
GLY A  68
ASP A 111
 ACT  A 402 (-3.4A)
None
None
None
None
 0.65A 4b17A-4gc5A:
11.2		 4b17A-4gc5A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_A_SAMA1263_0
(NON-STRUCTURAL
PROTEIN 5)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.92A 4ctjA-4gc5A:
7.5		 4ctjA-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.84A 4ctkA-4gc5A:
8.5		 4ctkA-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.64A 4ctkC-4gc5A:
8.3		 4ctkC-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 11 GLY A  63
GLY A  65
ILE A  69
ASN A 141
PRO A 143
 ACT  A 402 (-3.4A)
None
None
None
ACT  A 402 ( 4.9A)
 0.67A 4dcmA-4gc5A:
11.7		 4dcmA-4gc5A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 PRO A  66
GLY A  67
GLY A  68
ASP A 111
PRO A 143
 None
None
None
None
ACT  A 402 ( 4.9A)
 0.61A 4fp9D-4gc5A:
9.3		 4fp9D-4gc5A:
23.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		3 / 3 LYS A 258
TYR A 259
ARG A 262
 ACT  A 401 (-4.1A)
ACT  A 401 (-3.6A)
ACT  A 401 (-3.9A)
 0.24A 4gc9A-4gc5A:
47.1		 4gc9A-4gc5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		7 / 12 GLN A  35
LYS A  86
VAL A 112
ASN A 141
LEU A 142
PRO A 143
VAL A 146
 ACT  A 402 (-3.6A)
None
None
None
None
ACT  A 402 ( 4.9A)
None
 0.78A 4gc9A-4gc5A:
47.1		 4gc9A-4gc5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		11 / 12 LEU A  38
GLY A  63
GLY A  65
PRO A  66
ILE A  69
LYS A  86
VAL A 112
ASN A 141
LEU A 142
PRO A 143
VAL A 146
 None
ACT  A 402 (-3.4A)
None
None
None
None
None
None
None
ACT  A 402 ( 4.9A)
None
 0.32A 4gc9A-4gc5A:
47.1		 4gc9A-4gc5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		3 / 3 GLU A  85
ASP A  87
ASP A 111
 ACT  A 402 (-2.9A)
None
None
 0.15A 4gc9A-4gc5A:
47.1		 4gc9A-4gc5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A 168
ILE A 125
ASN A 135
ASN A 124
GLY A 123
 None
 1.22A 4obwD-4gc5A:
11.1		 4obwD-4gc5A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 5 PHE A 165
HIS A 137
LEU A 230
PRO A 164
 None
 1.22A 5csyB-4gc5A:
undetectable		 5csyB-4gc5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.61A 5e9qA-4gc5A:
8.3		 5e9qA-4gc5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.61A 5e9qC-4gc5A:
8.5		 5e9qC-4gc5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.55A 5ec8C-4gc5A:
7.9		 5ec8C-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.84A 5ehgA-4gc5A:
8.3		 5ehgA-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.93A 5ehiA-4gc5A:
8.4		 5ehiA-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.56A 5ehiC-4gc5A:
8.5		 5ehiC-4gc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.92A 5eifA-4gc5A:
8.2		 5eifA-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.87A 5eifC-4gc5A:
undetectable		 5eifC-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.63A 5eiwA-4gc5A:
8.5		 5eiwA-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
 ACT  A 402 (-3.4A)
None
None
None
None
 0.83A 5eiwA-4gc5A:
8.5		 5eiwA-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.66A 5eiwC-4gc5A:
8.3		 5eiwC-4gc5A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.61A 5ekxA-4gc5A:
8.4		 5ekxA-4gc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
 ACT  A 402 (-3.4A)
None
None
None
None
 0.90A 5ekxA-4gc5A:
8.4		 5ekxA-4gc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 7 GLY A  63
GLY A  65
GLU A  85
ASP A 111
 ACT  A 402 (-3.4A)
None
ACT  A 402 (-2.9A)
None
 0.48A 5ergB-4gc5A:
11.4		 5ergB-4gc5A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 11 GLY A  65
GLU A  85
ASP A 111
VAL A 112
PRO A 143
 None
ACT  A 402 (-2.9A)
None
None
ACT  A 402 ( 4.9A)
 0.63A 5hjiA-4gc5A:
11.7		 5hjiA-4gc5A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 9 ILE A 107
LEU A 105
GLU A  61
THR A  70
GLY A  65
 None
 1.18A 5ifuB-4gc5A:
undetectable		 5ifuB-4gc5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.72A 5ikmA-4gc5A:
8.3		 5ikmA-4gc5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 11 GLN A  35
VAL A  84
THR A  70
GLU A  61
TYR A 115
 ACT  A 402 (-3.6A)
None
None
None
None
 1.46A 5jh7B-4gc5A:
undetectable		 5jh7B-4gc5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.58A 5kqrA-4gc5A:
8.3		 5kqrA-4gc5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.56A 5kqsA-4gc5A:
8.1		 5kqsA-4gc5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.88A 5m5bA-4gc5A:
8.0		 5m5bA-4gc5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 7 GLY A  63
GLU A  85
LYS A  86
ASP A 111
ASN A 141
 ACT  A 402 (-3.4A)
ACT  A 402 (-2.9A)
None
None
None
 0.68A 5mvsA-4gc5A:
9.6		 5mvsA-4gc5A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 8 GLY A  63
GLU A  85
LYS A  86
ASP A 111
ASN A 141
 ACT  A 402 (-3.4A)
ACT  A 402 (-2.9A)
None
None
None
 0.38A 5mvsB-4gc5A:
9.7		 5mvsB-4gc5A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.59A 5njvA-4gc5A:
8.1		 5njvA-4gc5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 1.13A 5njvB-4gc5A:
7.9		 5njvB-4gc5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.81A 5njvC-4gc5A:
7.8		 5njvC-4gc5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		3 / 3 LYS A 171
HIS A 137
HIS A 229
 None
 1.41A 5oexA-4gc5A:
undetectable		 5oexA-4gc5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.80A 5vimB-4gc5A:
8.1		 5vimB-4gc5A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_A_SAMA601_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.84A 5wz1A-4gc5A:
8.0		 5wz1A-4gc5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_B_SAMB601_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.81A 5wz1B-4gc5A:
8.2		 5wz1B-4gc5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.83A 5wz1C-4gc5A:
8.1		 5wz1C-4gc5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.85A 5wz1D-4gc5A:
8.3		 5wz1D-4gc5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.82A 5wz1E-4gc5A:
7.9		 5wz1E-4gc5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.83A 5wz1F-4gc5A:
8.3		 5wz1F-4gc5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_G_SAMG601_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.87A 5wz1G-4gc5A:
8.0		 5wz1G-4gc5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  63
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
 0.84A 5wz1H-4gc5A:
8.1		 5wz1H-4gc5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.56A 5wz2A-4gc5A:
8.1		 5wz2A-4gc5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		6 / 12 GLY A  63
GLY A  65
GLY A  68
LYS A  86
ASP A 111
VAL A 112
 ACT  A 402 (-3.4A)
None
None
None
None
None
 0.82A 5wz2B-4gc5A:
8.3		 5wz2B-4gc5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 GLY A  65
GLY A  67
LYS A  86
LEU A 113
ASN A 141
 None
 1.06A 5ybbA-4gc5A:
10.4		 5ybbA-4gc5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA806_0
(GEPHYRIN)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		4 / 4 MET A 266
GLY A 265
HIS A 261
GLY A 263
 None
 1.25A 6fgdA-4gc5A:
undetectable		 6fgdA-4gc5A:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 LEU A  38
GLU A  61
GLY A  63
GLY A  65
ASP A  87
 None
None
ACT  A 402 (-3.4A)
None
None
 0.49A 6iftA-4gc5A:
27.3		 6iftA-4gc5A:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4gc5 DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL
(Mus
musculus) 		5 / 12 LEU A  38
GLY A  63
GLY A  65
ASP A  87
PRO A 143
 None
ACT  A 402 (-3.4A)
None
None
ACT  A 402 ( 4.9A)
 0.84A 6iftA-4gc5A:
27.3		 6iftA-4gc5A:
30.97