SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		5 / 10 ILE A 201
GLY A   9
ALA A  10
TYR A   6
HIS A  16
 None
None
GSH  A 302 ( 3.9A)
None
None
 1.25A 3boyA-4gciA:
undetectable
3boyC-4gciA:
undetectable		 3boyA-4gciA:
21.13
3boyC-4gciA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		5 / 10 TYR A   6
HIS A  16
ILE A 201
GLY A   9
ALA A  10
 None
None
None
None
GSH  A 302 ( 3.9A)
 1.24A 3boyA-4gciA:
undetectable
3boyB-4gciA:
undetectable		 3boyA-4gciA:
21.13
3boyB-4gciA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		5 / 10 TYR A   6
HIS A  16
ILE A 201
GLY A   9
ALA A  10
 None
None
None
None
GSH  A 302 ( 3.9A)
 1.25A 3boyB-4gciA:
undetectable
3boyC-4gciA:
undetectable		 3boyB-4gciA:
21.13
3boyC-4gciA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		5 / 12 GLY A  67
ALA A 157
VAL A  18
ALA A 103
VAL A  68
 GSH  A 302 (-4.0A)
None
None
None
None
 1.25A 4df3A-4gciA:
undetectable		 4df3A-4gciA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		5 / 12 GLY A  67
ALA A 157
VAL A  18
ALA A 103
VAL A  68
 GSH  A 302 (-4.0A)
None
None
None
None
 1.25A 4df3B-4gciA:
undetectable		 4df3B-4gciA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		4 / 4 ALA A 191
ALA A 194
ALA A 195
ALA A 198
 None
 0.09A 4oadA-4gciA:
undetectable		 4oadA-4gciA:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		4 / 4 ALA A 191
ALA A 194
ALA A 195
ALA A 198
 None
 0.09A 4oaeA-4gciA:
undetectable		 4oaeA-4gciA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4gci GLUTATHIONE
S-TRANSFERASE
(Yersinia
pestis) 		4 / 6 ALA A 155
LEU A 159
TYR A 182
SER A 153
 None
 1.07A 5phhA-4gciA:
undetectable		 5phhA-4gciA:
19.89