SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gd3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 5 GLU S  22
THR S  18
HIS S  13
LEU S  48
 None
 1.35A 1d4fC-4gd3S:
3.9		 1d4fC-4gd3S:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 5 ILE S  12
ILE S 160
ILE S 109
LEU S  48
 None
 0.91A 1zgyA-4gd3S:
undetectable		 1zgyA-4gd3S:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 6 ARG S 174
ASN S 228
PRO S 147
ALA S 253
 None
SF4  S 402 ( 4.5A)
None
SF4  S 402 ( 4.4A)
 1.32A 2ejfB-4gd3S:
undetectable		 2ejfB-4gd3S:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 6 GLN S 272
GLY S 274
HIS S 187
CYH S 215
 None
None
SF4  S 401 (-3.0A)
SF4  S 401 (-2.1A)
 1.22A 3ai8B-4gd3S:
undetectable		 3ai8B-4gd3S:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 8 ALA S 158
ILE S 159
PRO S 170
PRO S 178
 None
 0.87A 3fxrA-4gd3S:
undetectable		 3fxrA-4gd3S:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 VAL S 146
ALA S 253
ILE S 186
THR S 233
SER S 232
 None
SF4  S 402 ( 4.4A)
SF4  S 402 ( 4.9A)
None
None
 1.35A 3hbbB-4gd3S:
undetectable		 3hbbB-4gd3S:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		3 / 3 TYR S 182
ASP S 173
ASP S 171
 None
 0.97A 3ou7B-4gd3S:
undetectable		 3ou7B-4gd3S:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 9 PRO S 170
TYR S 162
ILE S 159
ILE S 110
ILE S  72
 None
 1.22A 3p4wB-4gd3S:
undetectable		 3p4wB-4gd3S:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 10 PRO S 170
TYR S 162
ILE S 159
ILE S 110
ILE S  72
 None
 1.21A 3p4wD-4gd3S:
undetectable		 3p4wD-4gd3S:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 10 PRO S 170
TYR S 162
ILE S 159
ILE S 110
ILE S  72
 None
 1.21A 3p4wE-4gd3S:
undetectable		 3p4wE-4gd3S:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		4 / 5 ALA S 116
GLU S  76
ALA S  74
MET S 156
 None
 1.41A 3r9tC-4gd3S:
undetectable		 3r9tC-4gd3S:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 4gd3 HYDROGENASE-1 SMALL
CHAIN
(Escherichia
coli) 		5 / 10 PRO S 142
MET S 163
ILE S 144
ILE S 110
ILE S 159
 None
 1.03A 5murE-4gd3S:
undetectable		 5murE-4gd3S:
11.48