SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 7 ILE A 150
TYR A 133
PHE A 171
PHE A 165
 None
 1.16A 1e71M-4gd5A:
undetectable		 1e71M-4gd5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 7 ILE A 150
TYR A 133
PHE A 171
PHE A 165
 None
 1.17A 1e72M-4gd5A:
undetectable		 1e72M-4gd5A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PW7_B_RABB646_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 9 ARG A 155
SER A  43
GLY A  45
GLU A 156
ILE A  66
 PO4  A 301 (-2.8A)
PO4  A 301 (-2.7A)
None
None
None
 1.34A 1pw7B-4gd5A:
undetectable		 1pw7B-4gd5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 7 SER A  89
ARG A  90
LEU A  92
GLU A  96
 PO4  A 301 (-2.7A)
None
None
None
 0.73A 2cdqB-4gd5A:
undetectable		 2cdqB-4gd5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		3 / 3 ILE A  75
SER A  41
SER A 159
 None
PO4  A 301 (-2.5A)
PO4  A 301 (-2.7A)
 0.48A 3iltH-4gd5A:
12.0		 3iltH-4gd5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		3 / 3 SER A 159
GLY A 160
THR A 161
 PO4  A 301 (-2.7A)
PO4  A 301 (-3.5A)
PO4  A 301 (-3.6A)
 0.08A 3k9wA-4gd5A:
undetectable		 3k9wA-4gd5A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 11 ASP A 163
ASN A  77
GLY A  86
SER A  39
GLY A 158
 None
 0.96A 3v3oC-4gd5A:
undetectable		 3v3oC-4gd5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 8 VAL A 153
TYR A 133
ILE A 189
ILE A 182
 None
None
None
CL  A 302 ( 4.5A)
 0.96A 4afgD-4gd5A:
undetectable
4afgE-4gd5A:
undetectable		 4afgD-4gd5A:
24.07
4afgE-4gd5A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 11 SER A  83
GLY A  86
VAL A 241
MET A  79
SER A  39
 None
 1.11A 4d9hA-4gd5A:
undetectable		 4d9hA-4gd5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 11 SER A  83
GLY A  86
VAL A 241
MET A  79
SER A  39
 None
 1.12A 4danA-4gd5A:
undetectable		 4danA-4gd5A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 6 ARG A 162
GLY A 185
ASP A 184
GLY A  70
 None
None
None
PO4  A 301 ( 3.8A)
 0.98A 4koeA-4gd5A:
undetectable
4koeB-4gd5A:
undetectable
4koeC-4gd5A:
undetectable		 4koeA-4gd5A:
21.01
4koeB-4gd5A:
21.01
4koeC-4gd5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 6 ALA A 164
ILE A 273
GLY A 110
SER A  41
 None
None
None
PO4  A 301 (-2.5A)
 0.80A 4r21A-4gd5A:
undetectable		 4r21A-4gd5A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 4 THR A 161
GLY A 185
ASP A 184
SER A  43
 PO4  A 301 (-3.6A)
None
None
PO4  A 301 (-2.7A)
 1.40A 4rfqA-4gd5A:
undetectable		 4rfqA-4gd5A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 6 GLY A 185
ASP A 184
GLY A  70
ARG A 162
 None
None
PO4  A 301 ( 3.8A)
None
 0.90A 4z53A-4gd5A:
undetectable
4z53B-4gd5A:
undetectable		 4z53A-4gd5A:
17.52
4z53B-4gd5A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 12 GLY A 201
ILE A 203
VAL A 193
VAL A 212
VAL A 208
 None
 1.12A 5dpdA-4gd5A:
undetectable		 5dpdA-4gd5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 12 GLY A 201
ILE A 203
VAL A 193
VAL A 212
VAL A 208
 None
 1.14A 5dpdB-4gd5A:
undetectable		 5dpdB-4gd5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 10 TYR A 133
TYR A 202
ILE A 189
ILE A 203
VAL A 153
 None
 1.40A 5mzrA-4gd5A:
undetectable		 5mzrA-4gd5A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		5 / 10 TYR A 133
TYR A 202
ILE A 189
ILE A 203
VAL A 153
 None
 1.40A 5mzrC-4gd5A:
undetectable		 5mzrC-4gd5A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 6 GLY A 158
ASP A 157
ARG A  90
ARG A 162
 None
 1.15A 6dwdA-4gd5A:
undetectable
6dwdC-4gd5A:
undetectable		 6dwdA-4gd5A:
19.00
6dwdC-4gd5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 5 GLY A 158
ASP A 157
ARG A  90
ARG A 162
 None
 1.13A 6dwdB-4gd5A:
undetectable
6dwdD-4gd5A:
undetectable		 6dwdB-4gd5A:
19.00
6dwdD-4gd5A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4gd5 PHOSPHATE ABC
TRANSPORTER,
PHOSPHATE-BINDING
PROTEIN
(Clostridium
perfringens) 		4 / 5 ARG A  90
ARG A 162
GLY A 158
ASP A 157
 None
 1.14A 6dwjB-4gd5A:
undetectable
6dwjD-4gd5A:
undetectable		 6dwjB-4gd5A:
19.00
6dwjD-4gd5A:
19.00