SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gdj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))
4gdj NEURAMINIDASE
(Influenza
A
virus)
5 / 10 LEU A 257
VAL A 262
ILE A 205
LEU A 225
VAL A 241
None
0.98A 1cqpA-4gdjA:
undetectable
1cqpB-4gdjA:
undetectable
1cqpA-4gdjA:
19.94
1cqpB-4gdjA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
4gdj NEURAMINIDASE
(Influenza
A
virus)
4 / 7 VAL A 262
GLY A 260
THR A 190
ILE A 205
None
0.65A 1gtnC-4gdjA:
undetectable
1gtnD-4gdjA:
undetectable
1gtnC-4gdjA:
13.38
1gtnD-4gdjA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)
4gdj NEURAMINIDASE
(Influenza
A
virus)
3 / 3 SER A 179
THR A 279
GLN A 350
None
0.79A 2fk8A-4gdjA:
undetectable
2fk8A-4gdjA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)
4gdj NEURAMINIDASE
(Influenza
A
virus)
4 / 5 LEU A 303
GLY A 291
PRO A 301
ILE A 273
None
None
None
FUC  A 503 ( 4.2A)
0.84A 2q9rA-4gdjA:
undetectable
2q9rA-4gdjA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)
4gdj NEURAMINIDASE
(Influenza
A
virus)
4 / 8 GLN A 441
TYR A 277
ARG A 119
THR A 292
None
0.98A 2vxaF-4gdjA:
undetectable
2vxaG-4gdjA:
undetectable
2vxaI-4gdjA:
undetectable
2vxaF-4gdjA:
12.11
2vxaG-4gdjA:
12.11
2vxaI-4gdjA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)
4gdj NEURAMINIDASE
(Influenza
A
virus)
4 / 8 GLU A 256
GLN A 258
GLY A 235
SER A 236
None
NAG  A 505 (-3.4A)
None
None
0.91A 4f93B-4gdjA:
undetectable
4f93B-4gdjA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)
4gdj NEURAMINIDASE
(Influenza
A
virus)
4 / 6 SER A 123
TYR A 121
LYS A 160
PHE A 132
None
1.29A 5dlvA-4gdjA:
1.9
5dlvA-4gdjA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)
4gdj NEURAMINIDASE
(Influenza
A
virus)
4 / 7 SER A 123
TYR A 121
LYS A 160
PHE A 132
None
1.23A 5dlvB-4gdjA:
undetectable
5dlvB-4gdjA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)
4gdj NEURAMINIDASE
(Influenza
A
virus)
5 / 10 THR A 362
ILE A 353
LEU A 302
GLY A 320
ALA A 321
None
1.19A 5mxbA-4gdjA:
undetectable
5mxbA-4gdjA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)
4gdj NEURAMINIDASE
(Influenza
A
virus)
4 / 6 GLU A 356
ALA A 360
LEU A 354
TYR A 281
None
0.86A 5phhA-4gdjA:
undetectable
5phhA-4gdjA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)
4gdj NEURAMINIDASE
(Influenza
A
virus)
4 / 8 GLY A 351
GLN A 350
SER A 363
TYR A 281
None
1.17A 6eqpA-4gdjA:
undetectable
6eqpA-4gdjA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)
4gdj NEURAMINIDASE
(Influenza
A
virus)
4 / 8 GLY A 351
GLN A 350
THR A 279
PHE A 374
None
1.10A 6eqpA-4gdjA:
undetectable
6eqpA-4gdjA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
4gdj NEURAMINIDASE
(Influenza
A
virus)
4 / 7 GLN A 350
GLY A 408
PHE A 422
VAL A 420
None
1.03A 6hu9S-4gdjA:
undetectable
6hu9q-4gdjA:
undetectable
6hu9S-4gdjA:
14.95
6hu9q-4gdjA:
17.27