SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gdl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		5 / 10 LEU B  45
VAL B 102
VAL B  52
TRP B  98
LEU B  77
 None
 1.32A 1lw0A-4gdlB:
undetectable		 1lw0A-4gdlB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4gdl AUTOPHAGY PROTEIN 5
AUTOPHAGY-RELATED
PROTEIN 16-1
(Homo
sapiens;
Homo
sapiens) 		4 / 7 LEU C  21
ILE C  17
ILE B 267
PRO B 245
 None
 0.91A 1oniB-4gdlC:
undetectable
1oniC-4gdlC:
undetectable		 1oniB-4gdlC:
12.32
1oniC-4gdlC:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 4gdl AUTOPHAGY PROTEIN 5
UBIQUITIN-LIKE
PROTEIN ATG12
(Homo
sapiens) 		4 / 7 PHE A 123
GLU B 131
GLN A 114
GLU A 121
 None
 1.30A 2aowA-4gdlA:
undetectable		 2aowA-4gdlA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		4 / 8 PHE B 182
TYR B 175
LEU B 265
PRO B 186
 None
 1.14A 3jq7B-4gdlB:
undetectable		 3jq7B-4gdlB:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU B  45
VAL B 102
VAL B  52
TRP B  98
LEU B  77
 None
 1.31A 3meeA-4gdlB:
undetectable		 3meeA-4gdlB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		5 / 12 PHE B 165
VAL B  42
PRO B 261
ASN B 169
MET B 173
 None
 1.47A 3nbrA-4gdlB:
undetectable		 3nbrA-4gdlB:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		5 / 12 TRP B 253
LEU B 247
VAL B 222
ILE B 240
VAL B 238
 None
 1.09A 3w67B-4gdlB:
undetectable		 3w67B-4gdlB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		5 / 12 TRP B 253
LEU B 247
VAL B 222
ILE B 240
VAL B 238
 None
 1.21A 3w68C-4gdlB:
undetectable		 3w68C-4gdlB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU B  45
VAL B 102
VAL B  52
TRP B  98
LEU B  77
 None
 1.23A 5cymA-4gdlB:
undetectable		 5cymA-4gdlB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU B  45
VAL B 102
VAL B  52
TRP B  98
LEU B  77
 None
 1.23A 5cyqA-4gdlB:
undetectable		 5cyqA-4gdlB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		3 / 3 HIS B 257
GLU B 256
TRP B 253
 None
 0.94A 5odqD-4gdlB:
undetectable		 5odqD-4gdlB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		4 / 8 ILE B 189
ILE B 227
LEU B 215
THR B 214
 None
 0.67A 5og9A-4gdlB:
undetectable		 5og9A-4gdlB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		4 / 8 VAL B 238
ILE B 227
LEU B 215
THR B 214
 None
 0.49A 5og9A-4gdlB:
undetectable		 5og9A-4gdlB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 4gdl AUTOPHAGY PROTEIN 5
AUTOPHAGY-RELATED
PROTEIN 16-1
(Homo
sapiens) 		4 / 6 PRO C  11
PRO B 250
LEU B 254
LEU B 212
 None
 1.07A 5tl8A-4gdlC:
undetectable		 5tl8A-4gdlC:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		4 / 6 VAL B 222
LEU B 215
LEU B 251
HIS B 213
 None
 0.96A 6e43A-4gdlB:
undetectable		 6e43A-4gdlB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		4 / 6 VAL B 222
LEU B 215
LEU B 251
HIS B 213
 None
 0.99A 6e43B-4gdlB:
undetectable		 6e43B-4gdlB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		4 / 6 VAL B 222
LEU B 215
LEU B 251
HIS B 213
 None
 0.96A 6e43C-4gdlB:
undetectable		 6e43C-4gdlB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 4gdl AUTOPHAGY PROTEIN 5
(Homo
sapiens) 		5 / 12 LEU B  45
VAL B 102
VAL B  52
TRP B  98
LEU B  77
 None
 1.22A 6eliA-4gdlB:
undetectable		 6eliA-4gdlB:
19.79