SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gdn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		4 / 8 HIS A 124
LEU A 115
ALA A 110
LEU A 109
 None
 0.96A 1hwiB-4gdnA:
undetectable		 1hwiB-4gdnA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		6 / 12 PRO A  88
THR A 271
ILE A  56
GLY A  58
ILE A  61
ALA A 240
 None
 1.43A 1sg9B-4gdnA:
undetectable		 1sg9B-4gdnA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		4 / 6 TRP A 315
TYR A 311
PHE A 336
SER A 335
 None
 1.16A 2a3cA-4gdnA:
undetectable		 2a3cA-4gdnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		4 / 6 TRP A 315
TYR A 311
PHE A 336
SER A 335
 None
 1.24A 2a3cB-4gdnA:
undetectable		 2a3cB-4gdnA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		5 / 10 ASP A 170
SER A 149
ILE A 151
LEU A 259
GLY A 199
 None
 1.27A 2v0mA-4gdnA:
undetectable		 2v0mA-4gdnA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		5 / 12 ASN A  97
ILE A 278
VAL A  64
ILE A  63
ILE A 347
 None
 1.23A 3kpbA-4gdnA:
undetectable		 3kpbA-4gdnA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		5 / 12 ILE A 278
VAL A  64
ILE A  63
ASN A 366
ILE A 347
 None
 0.98A 3kpdB-4gdnA:
undetectable		 3kpdB-4gdnA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		5 / 9 ALA A 312
GLY A 314
LEU A 107
LEU A 145
ILE A 106
 None
 1.12A 3wdmC-4gdnA:
undetectable		 3wdmC-4gdnA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		5 / 12 TYR A 190
THR A 329
ALA A  95
ALA A 265
ASN A  97
 None
 1.45A 4u14A-4gdnA:
undetectable		 4u14A-4gdnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		5 / 12 TYR A 190
THR A 329
ALA A  95
ALA A 265
ASN A  97
 None
 1.37A 4u15B-4gdnA:
undetectable		 4u15B-4gdnA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		5 / 12 GLY A 199
ASN A 169
ILE A 106
PHE A 229
ILE A 214
 None
 1.26A 4zvmA-4gdnA:
undetectable
4zvmB-4gdnA:
undetectable		 4zvmA-4gdnA:
21.41
4zvmB-4gdnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		4 / 8 THR A 206
GLY A 199
ALA A 105
HIS A 124
 None
 0.97A 5ef3L-4gdnA:
undetectable
5ef3V-4gdnA:
undetectable		 5ef3L-4gdnA:
13.55
5ef3V-4gdnA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		3 / 3 THR A 271
SER A 270
TYR A  92
 None
 0.84A 5jsdA-4gdnA:
undetectable		 5jsdA-4gdnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		3 / 3 THR A 271
SER A 270
TYR A  92
 None
 0.84A 5jsdB-4gdnA:
undetectable		 5jsdB-4gdnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		3 / 3 THR A 271
SER A 270
TYR A  92
 None
 0.84A 5jsdC-4gdnA:
undetectable		 5jsdC-4gdnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		3 / 3 THR A 271
SER A 270
TYR A  92
 None
 0.82A 5jseA-4gdnA:
undetectable		 5jseA-4gdnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		3 / 3 THR A 271
SER A 270
TYR A  92
 None
 0.82A 5jseB-4gdnA:
undetectable		 5jseB-4gdnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		3 / 3 THR A 271
SER A 270
TYR A  92
 None
 0.83A 5jseC-4gdnA:
undetectable		 5jseC-4gdnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		4 / 7 LEU A  62
THR A 269
ILE A  94
LEU A 350
 None
 0.85A 5te8A-4gdnA:
undetectable		 5te8A-4gdnA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_C_SAMC201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		5 / 12 LEU A 350
SER A 270
LEU A 274
LEU A  62
VAL A 348
 None
 1.17A 5twjC-4gdnA:
undetectable		 5twjC-4gdnA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 4gdn PROTEIN FLP
(Staphylococcus
aureus) 		5 / 12 LEU A 323
TYR A 345
GLY A 346
PRO A 341
GLU A 275
 None
 1.25A 5x6yC-4gdnA:
undetectable		 5x6yC-4gdnA:
18.79