SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ged'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		5 / 8 HIS A 192
GLY A 195
MET A 248
LEU A 250
ASP A 253
 HEM  A 401 (-3.4A)
HEM  A 401 (-3.2A)
None
None
None
 0.43A 1aegA-4gedA:
36.6		 1aegA-4gedA:
39.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		4 / 6 LEU A 290
GLY A 179
LYS A  78
TYR A  73
 None
 1.17A 1gtiC-4gedA:
undetectable		 1gtiC-4gedA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		4 / 5 LEU A 290
GLY A 179
LYS A  78
TYR A  73
 None
 1.17A 1gtiF-4gedA:
undetectable		 1gtiF-4gedA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		4 / 7 PRO A 157
LEU A 178
GLY A  80
GLU A  92
 None
None
None
MG  A 403 (-3.0A)
 1.01A 3tehB-4gedA:
undetectable		 3tehB-4gedA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		3 / 3 ASP A  74
LYS A  78
ASP A  79
 None
 0.71A 4a7tA-4gedA:
undetectable		 4a7tA-4gedA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AT0_A_ACTA1490_0
(3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		3 / 3 GLU A  49
TYR A 134
SER A  53
 None
 0.90A 4at0A-4gedA:
undetectable		 4at0A-4gedA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		4 / 8 HIS A  68
ASN A  98
ASP A 163
ASP A 158
 None
 1.07A 4l7iA-4gedA:
undetectable		 4l7iA-4gedA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		5 / 12 VAL A 125
ALA A 127
TYR A 129
SER A 119
THR A 288
 None
 1.38A 4mm4A-4gedA:
undetectable		 4mm4A-4gedA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		5 / 12 GLY A  59
PHE A 284
ILE A  63
ALA A 191
PHE A 215
 None
HEM  A 401 ( 4.8A)
HEM  A 401 ( 4.1A)
HEM  A 401 (-3.3A)
None
 1.34A 4wh5A-4gedA:
undetectable		 4wh5A-4gedA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		3 / 3 LYS A 297
TRP A 144
SER A  34
 None
 0.98A 5nwwA-4gedA:
undetectable		 5nwwA-4gedA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB806_1
(CATALASE-PEROXIDASE)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		4 / 5 ARG A  64
TRP A  67
HIS A  68
SER A 202
 HEM  A 401 ( 4.2A)
HEM  A 401 (-3.4A)
None
HEM  A 401 (-2.6A)
 0.41A 5syiB-4gedA:
8.4		 5syiB-4gedA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		4 / 6 ARG A  64
TRP A  67
HIS A  68
SER A 202
 HEM  A 401 ( 4.2A)
HEM  A 401 (-3.4A)
None
HEM  A 401 (-2.6A)
 0.42A 5syjA-4gedA:
31.2		 5syjA-4gedA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		4 / 6 ARG A  64
TRP A  67
HIS A  68
SER A 202
 HEM  A 401 ( 4.2A)
HEM  A 401 (-3.4A)
None
HEM  A 401 (-2.6A)
 0.45A 5syjB-4gedA:
12.5		 5syjB-4gedA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		5 / 12 LEU A  62
LEU A  65
ALA A  66
LEU A 123
ILE A  52
 None
 0.94A 5toaA-4gedA:
undetectable		 5toaA-4gedA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		4 / 7 ILE A 140
LEU A 188
THR A 193
ARG A 275
 None
HEM  A 401 (-4.1A)
K  A 402 (-3.4A)
None
 0.91A 5vc0A-4gedA:
undetectable		 5vc0A-4gedA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 4ged ASCORBATE PEROXIDASE
(Leishmania
major) 		4 / 8 GLY A 145
THR A 292
SER A 119
TYR A 129
 None
 1.14A 6eqpA-4gedA:
undetectable		 6eqpA-4gedA:
19.10