SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gei'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 4gei THIOREDOXIN-INTERACT
ING PROTEIN
(Homo
sapiens) 		3 / 3 GLN A 137
THR A 136
LEU A  76
 None
 0.75A 3ondB-4geiA:
undetectable		 3ondB-4geiA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4gei THIOREDOXIN-INTERACT
ING PROTEIN
(Homo
sapiens) 		5 / 12 GLY A 102
ILE A  46
ALA A  48
PHE A 143
VAL A 125
 None
 1.15A 4u8vB-4geiA:
undetectable		 4u8vB-4geiA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4gei THIOREDOXIN-INTERACT
ING PROTEIN
(Homo
sapiens) 		4 / 6 TYR A 123
GLY A 108
SER A  23
LEU A 105
 None
 1.17A 5bphA-4geiA:
undetectable		 5bphA-4geiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_B_ACTB404_0
(D-ALANINE--D-ALANINE
LIGASE)		 4gei THIOREDOXIN-INTERACT
ING PROTEIN
(Homo
sapiens) 		4 / 7 TYR A 123
GLY A 108
SER A  23
LEU A 105
 None
 1.07A 5bphB-4geiA:
undetectable		 5bphB-4geiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4gei THIOREDOXIN-INTERACT
ING PROTEIN
(Homo
sapiens) 		4 / 4 TYR A 123
GLY A 108
SER A  23
LEU A 105
 None
 1.15A 5bphC-4geiA:
undetectable		 5bphC-4geiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 4gei THIOREDOXIN-INTERACT
ING PROTEIN
(Homo
sapiens) 		4 / 6 TYR A 123
GLY A 108
SER A  23
LEU A 105
 None
 1.06A 5bphD-4geiA:
undetectable		 5bphD-4geiA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 4gei THIOREDOXIN-INTERACT
ING PROTEIN
(Homo
sapiens) 		4 / 6 VAL A  44
VAL A  31
TYR A  99
ILE A   7
 None
 0.90A 5pbeA-4geiA:
undetectable		 5pbeA-4geiA:
20.24