SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4gek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		3 / 3 GLY A  64
ASP A  89
ASN A 132
 GEK  A 302 (-3.7A)
GEK  A 302 (-2.8A)
GEK  A 302 (-3.7A)
 0.61A 1vq1A-4gekA:
12.2		 1vq1A-4gekA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		4 / 7 ALA A  70
SER A  73
ASP A  62
ILE A  42
 GEK  A 302 ( 4.1A)
None
GEK  A 302 ( 4.5A)
None
 0.93A 1yc5A-4gekA:
2.8		 1yc5A-4gekA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 LEU A 147
ASP A 117
ILE A  88
GLY A  64
LEU A 160
 None
GEK  A 302 (-3.2A)
None
GEK  A 302 (-3.7A)
None
 0.99A 2o4nA-4gekA:
undetectable		 2o4nA-4gekA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 11 LEU A 131
LEU A 162
ILE A 150
ALA A 240
LEU A 154
 None
 1.12A 2q72A-4gekA:
undetectable		 2q72A-4gekA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 LEU A 131
LEU A 162
ILE A 150
ALA A 240
LEU A 154
 None
 1.07A 2qb4A-4gekA:
undetectable		 2qb4A-4gekA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		6 / 11 LEU A 131
LEU A 162
ILE A 150
ALA A 240
PHE A 223
LEU A 154
 None
 1.20A 2qjuA-4gekA:
undetectable		 2qjuA-4gekA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		3 / 3 ALA A  87
THR A  71
CYH A  98
 None
 0.73A 3e4eA-4gekA:
undetectable		 3e4eA-4gekA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 LEU A 131
LEU A 162
ILE A 150
ALA A 240
LEU A 154
 None
 1.04A 3gwvA-4gekA:
undetectable		 3gwvA-4gekA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 11 SER A 196
ILE A 195
VAL A  27
PHE A  28
VAL A  24
 None
None
None
GEK  A 302 (-4.9A)
None
 1.38A 3rf4A-4gekA:
undetectable
3rf4C-4gekA:
undetectable		 3rf4A-4gekA:
20.23
3rf4C-4gekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 11 SER A 196
ILE A 195
VAL A  27
PHE A  28
VAL A  24
 None
None
None
GEK  A 302 (-4.9A)
None
 1.35A 3rf4A-4gekA:
undetectable
3rf4B-4gekA:
undetectable		 3rf4A-4gekA:
20.23
3rf4B-4gekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 11 ILE A  32
SER A 196
ILE A 195
VAL A  27
VAL A  24
 None
 1.31A 3rf4B-4gekA:
undetectable
3rf4C-4gekA:
undetectable		 3rf4B-4gekA:
20.23
3rf4C-4gekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 11 SER A 196
ILE A 195
VAL A  27
PHE A  28
VAL A  24
 None
None
None
GEK  A 302 (-4.9A)
None
 1.35A 3rf4B-4gekA:
undetectable
3rf4C-4gekA:
undetectable		 3rf4B-4gekA:
20.23
3rf4C-4gekA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 GLY A  64
ASP A  89
MET A  94
ASP A 117
LEU A 138
 GEK  A 302 (-3.7A)
GEK  A 302 (-2.8A)
GEK  A 302 (-4.6A)
GEK  A 302 (-3.2A)
None
 0.72A 4iv8A-4gekA:
17.9		 4iv8A-4gekA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		3 / 3 VAL A  54
GLN A  59
CYH A  83
 None
 0.78A 5icxA-4gekA:
undetectable
5icxE-4gekA:
undetectable		 5icxA-4gekA:
20.60
5icxE-4gekA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		3 / 3 VAL A  54
GLN A  59
CYH A  83
 None
 0.83A 5icxC-4gekA:
undetectable
5icxF-4gekA:
undetectable		 5icxC-4gekA:
20.60
5icxF-4gekA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 ASP A 117
ILE A 118
ARG A 119
LEU A 138
GLY A  64
 GEK  A 302 (-3.2A)
GEK  A 302 (-3.8A)
None
None
GEK  A 302 (-3.7A)
 1.02A 5il1A-4gekA:
4.1		 5il1A-4gekA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 ASP A 117
ILE A 118
ARG A 119
ASN A 132
GLY A  64
 GEK  A 302 (-3.2A)
GEK  A 302 (-3.8A)
None
GEK  A 302 (-3.7A)
GEK  A 302 (-3.7A)
 1.16A 5k7uA-4gekA:
1.4		 5k7uA-4gekA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 ASP A 117
ILE A 118
ARG A 119
LEU A 138
GLY A  64
 GEK  A 302 (-3.2A)
GEK  A 302 (-3.8A)
None
None
GEK  A 302 (-3.7A)
 1.09A 5k7uA-4gekA:
1.4		 5k7uA-4gekA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 THR A 134
ALA A  69
GLY A  68
ALA A  70
ILE A  43
 GEK  A 302 ( 3.8A)
SO4  A 301 (-3.7A)
None
GEK  A 302 ( 4.1A)
None
 0.86A 5kb6A-4gekA:
3.9		 5kb6A-4gekA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 VAL A 173
SER A 237
LEU A 228
VAL A 211
HIS A 214
 None
 0.98A 5ubbA-4gekA:
17.2		 5ubbA-4gekA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		4 / 6 PRO A  56
GLY A  57
THR A  58
ASN A  82
 None
 1.10A 5xxiA-4gekA:
undetectable		 5xxiA-4gekA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		4 / 6 PRO A  56
GLY A  57
THR A  58
LYS A  84
 None
 1.06A 5xxiA-4gekA:
undetectable		 5xxiA-4gekA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE
(Escherichia
coli) 		5 / 12 GLY A  68
ASP A  62
ILE A  85
VAL A 130
LEU A  72
 None
GEK  A 302 ( 4.5A)
None
None
SO4  A 301 ( 4.0A)
 1.07A 6bq4B-4gekA:
12.1		 6bq4B-4gekA:
18.10